DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-2 and Ace3

DIOPT Version :9

Sequence 1:	NP_788042.1	Gene:	Ance-2 / 34806	FlyBaseID:	FBgn0032535	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001245166.1	Gene:	Ace3 / 498012	RGDID:	1561299	Length:	737	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	172/640 - (26%)
Similarity:	284/640 - (44%)	Gaps:	65/640 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIFAVLLLVGLTQAGSQP--------DATLERFLNETNQQLAVIYDQAVLAQLLNELR------- 51
            |.|.::||.     ..||        :.:|:.|.:|...::.:.:.:.....:||||.
  Rat     5 WAFLLVLLY-----YGQPLPWPKTVGEPSLDEFYSEAQAKMFLQFYEQTARVVLNELMEATWNYV 64

  Fly    52 ---GPNDLVALLEIEVTDDKLVKYVRTLTTRKAKFKRLGLGDSRQRRLLDKIPQLGYEALSGRDL 113
               ...:...:|:.||...:.:.|   ..||...|:.....|...:|.|.|:..:...||...|.
  Rat    65 TNITKQNQENMLQKEVERSQFMLY---FGTRARMFRIDHFQDLDVKRRLSKLRNIDKSALPVEDF 126

  Fly   114 KLVYALASSMSDNYHNVKLCAYKQPGNCTLRLIPEVQSIVQGSRDLDEIEYYWFEWRSRTGLATR 178
            :....|.:.|...|...::|.  ..|.| :.|.|:::.|:..|||..|:.:.|..||...|...|
  Rat   127 QEFNRLLTYMKTAYGRAEVCL--DEGPC-MPLEPDLEEIMATSRDQKELLWAWQGWRDAIGRQLR 188

  Fly   179 SQFVDFMDLYKKTAQLNGYPRAEDYWFRSLELKGQETMNL-LDRIMHGLRPLFLQFHAHVRGSLR 242
            ..|.|::.|..|.||.|||......|....|   .:|:.. |:::...|:||:|..||:||.||.
  Rat   189 PVFEDYVHLSNKAAQYNGYKDMGALWRSKYE---SDTLEEDLEQLYKELQPLYLNLHAYVRRSLY 250

  Fly   243 KMHGEHLVPRNRPYPQHLAEVFIGNAFRRVEAEW---------YVDLPSPEIGLANITQELHRRG 298
            :.:|..|:....|.|.||    :||.:.:   .|         |.:.|..:|  ..|.:..|.|
  Rat   251 RYYGPELIDLRGPIPAHL----LGNMWAQ---SWNNILDLVLPYPNKPPEDI--TKIMKNQHWR- 305

  Fly   299 LSTTQRVFWNVAEYFRALGFPQLENSLW--TYAQKVSSDDDDRCWHKAWRYYALPRTNFTYCPLN 361
               .:::|.....:|.::|......:.|  :..:|.....:..|...:|.:|.|.......|...
  Rat   306 ---PEKMFEEANLFFTSMGMLPAPPAFWMKSMMEKPVDGREVECHTSSWNFYRLNDFRVKKCTEV 367

  Fly   362 DEERFFNMFEAQSDLQYYRAASIQPTLLQEEPFPNFSDAIGKCFSMAASSPRFLRKLGMLRDNKW 426
            ......::|.....:|||........:.||...|.|.:|:|...:::|.|.::|...|:| ..:.
  Rat   368 TIGDLLSIFHQMGHIQYYLQCQNLSIIYQEGASPAFEEAVGSTITLSAFSHKYLLTRGLL-SQQH 431

  Fly   427 KELPARLNRLYIQGLRVVFLLPVFYVLDRYRVEVLAGHIKADD-NEAYWRLTELYTGAAAPTKRT 490
            ::....:|.|....|..:..:|..|::|.:|.:|..|.|:.:. |:.:|.|...|.|...|..|:
  Rat   432 QDSEEEVNFLLSIALEKIAFIPFGYMIDLFRWKVFDGTIQKNAYNQEWWSLRLKYQGLCPPVPRS 496

  Fly   491 NEQFDVPAKLLMEVDDQYASNFLSIVLQFQLLKHFCTITGQFEMGNPRKPLDMCDLSDQRGIGEI 555
            .:.||..||..:..:..|...|||:||||||.:..|..:|  .:|    ||..||:.:.:..|:|
  Rat   497 EDDFDPGAKFHIPANMPYIRYFLSLVLQFQLHEVLCRASG--HVG----PLHRCDIYNSKVAGKI 555

  Fly   556 LKRAMSLGSSVHYREVLKVLLGEPEISIDGLLTYFQPLQDWLQHQNQENNLEVGW 610
            |...:.:|||..::||||.:.|:|.||...|||||:||.:||..:|.:....:||
  Rat   556 LGDFLKVGSSRPWQEVLKEITGKPNISTKALLTYFKPLLNWLVTENVKQGDILGW 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-2	NP_788042.1	GluZincin	26..601	CDD:301352	162/597 (27%)
Ace3	NP_001245166.1	Peptidase_M2	34..610	CDD:279709	162/604 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020