DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-2 and Ance-4

DIOPT Version :9

Sequence 1:	NP_788042.1	Gene:	Ance-2 / 34806	FlyBaseID:	FBgn0032535	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_610442.2	Gene:	Ance-4 / 35909	FlyBaseID:	FBgn0033366	Length:	609	Species:	Drosophila melanogaster

Alignment Length:	653	Identity:	169/653 - (25%)
Similarity:	282/653 - (43%)	Gaps:	93/653 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIFAVLLL---VGLTQAGSQPDATLERFLNETNQQLAVIYDQ---------------AVLAQLL 47
            |.:..:|:|   :|...|.:..|...:.|:|:::.:....|::               |:.::|.
  Fly     1 MGLLLLLVLIAGIGCATAAANIDLEAKTFVNQSSDRYYRFYNEIAAETYSANNEEDFDALFSKLN 65

  Fly    48 NELRGPNDLVALLEIEVTDDKLVKYVRTLTTRKAKFKRLGLGDSRQRRLLDKIPQLGYEALSGRD 112
            |..|...:||::.....|.|  :..:|:..|:.|..:....||         :..||.:..|...
  Fly    66 NVKRIAEELVSISRQAATYD--LDRIRSPQTKMALQELRTAGD---------LFVLGDDYFSSVQ 119

  Fly   113 LKLVYALASSMSDNYHNVKLCAYKQPG--NCTLRLIPEVQSIVQGSRDLDEIEYYWFEWRSRTGL 175
            :.|. ||.:..:|......|.....|.  :..|...|::|.|||.|:|.||::|||..||.:..|
  Fly   120 MNLA-ALQTLSTDKDIEPYLGGANMPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAWRDKNQL 183

  Fly   176 ATRSQFVDFMDLYKKTAQLNGYPRAEDYWFRSLELKGQETMNLLDRIMHGLRPLFLQFHAHVRGS 240
            .....|...:..|::.|::...| ....|:|   ...||.:..:::.|..|||.:.|.||.||..
  Fly   184 WASLNFYTIVQSYQRAAKILEVP-VHKLWYR---YDSQEMLQQMEQAMTELRPAYQQLHAFVRQE 244

  Fly   241 LRKMHGEHLVPRNRPYPQHLAEVFIGNAFR--RVEAEWYVDLPSPEIGLANITQELHRRGLSTTQ 303
            |.|.:|..:|..|.|.|.||.:..:..|:.  .:..::|.....||..  .....|       |.
  Fly   245 LHKKYGSDVVNLNGPIPDHLFQQVLEQAWASGSILEDYYPRAQLPEFD--EYVSHL-------TA 300

  Fly   304 RVFWNVAE-YFRALGFPQLENSLWTYAQKVSSDD--DDRCWHKAWRYYALPRTNFTYCPLNDEER 365
            :...|.:| ::.:|||..|.........|..:.|  :|.|  :...:...|.....||   ::..
  Fly   301 KTMVNESENFYTSLGFEPLSAEFHKNQLKEPNQDSPNDDC--RPSIFDLTPHVYLMYC---EKVS 360

  Fly   366 FFNMFEAQSDLQ--YYRAASIQPTLLQEEPFP-------NFSDAIGKCFSMAASSPRFL--RKLG 419
            |..:.:..|.:.  ||..        |:...|       |...|:|:...::||||..|  |:|.
  Fly   361 FRKLMQYHSHMARVYYAQ--------QKSHLPSYYFKAYNLEFAVGEAVVLSASSPAHLTGRRLA 417

  Fly   420 MLRDNKWKEL---PARLNRLYIQGLRVVFLLPVFYVLDRYRVEVLAGHIKADD-NEAYWRLTELY 480
                   ||:   .|.::||:...:..:..:|::||..:...::|...:..|. |:.||||.|.:
  Fly   418 -------KEVLSETALMSRLFRMAIHTILSIPLYYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQH 475

  Fly   481 TGAAAPTKRTNEQFDVPAKLLMEVDDQY-ASNFLSIVLQFQLLKHFCTITGQFEMGNPRKPLDMC 544
            .|..||:.|:....|.|.|..:.:|..: ...|:|.||.:|..:.||      :....|.||..|
  Fly   476 AGIEAPSDRSEGAIDFPYKFYVNIDQSFQTQKFISEVLGYQFYREFC------KKSYNRGPLHNC 534

  Fly   545 DLSDQRGIGEILKRAMSLGSSVHYREVL-KVLLGEPEISIDGLLTYFQPLQDWLQHQNQENNLEV 608
            |......:|..||..|||||:..:::|: |:|.....:|...||.|:||:.|||...|::.|.::
  Fly   535 DFYGSLAVGNDLKAMMSLGSTKPWKQVVGKILPNNTGLSSLALLEYYQPVLDWLNKYNKDANSKI 599

  Fly   609 GWT 611
            |||
  Fly   600 GWT 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-2	NP_788042.1	GluZincin	26..601	CDD:301352	158/613 (26%)
Ance-4	NP_610442.2	GluZincin	25..601	CDD:301352	160/626 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920