DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-2 and Ace

DIOPT Version :9

Sequence 1:	NP_788042.1	Gene:	Ance-2 / 34806	FlyBaseID:	FBgn0032535	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_036676.1	Gene:	Ace / 24310	RGDID:	2493	Length:	1313	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	154/598 - (25%)
Similarity:	268/598 - (44%)	Gaps:	29/598 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DATLERFLNETNQQLAVIYDQAVLA--QLLNELRGPNDLVALLEIEVTDDKLVKYVRTLTTRKAK 82
            :|...||:.|.::...|::::...|  .....:......:.|.:.:...:..:||    .|....
  Rat   652 EAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKY----GTWAKT 712

  Fly    83 FKRLGLGDSRQRRLLDKIPQLGYEALSGRDLKLVYALASSMSDNYHNVKLCAYKQPGNCTLRLIP 147
            |......:|..:|::.|:..:....|...:|:....:...|...|....:| |.. |.| |.|.|
  Rat   713 FDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVC-YTN-GTC-LSLEP 774

  Fly   148 EVQSIVQGSRDLDEIEYYWFEWRSRTGLATRSQFVDFMDLYKKTAQLNGYPRAEDYWFRSLELKG 212
            ::.:|:..||..:|:.:.|..||.:.|.|....|..::|...|.|:||||..|.|.|..|.|  .
  Rat   775 DLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYE--S 837

  Fly   213 QETMNLLDRIMHGLRPLFLQFHAHVRGSLRKMHGEHLVPRNRPYPQHLAEVFIGNAFRRVEAEWY 277
            .:....|:::...|:||:|..||:||.||.:.:|...:..:.|.|.||    :||.:.:..:..|
  Rat   838 DDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHL----LGNMWAQTWSNIY 898

  Fly   278 VDL--PSPEIGLANITQELHRRGLSTTQRVFWNVAEYFRALGFPQLENSLW--TYAQKVSSDDDD 338
             ||  |.|.....:.|:.:.::|. |.:|:|.....:|.:||...:....|  :..:|.:...:.
  Rat   899 -DLVAPFPSAPSIDATEAMIKQGW-TPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREV 961

  Fly   339 RCWHKAWRYYALPRTNFTYCPLNDEERFFNMFEAQSDLQYYRAASIQPTLLQEEPFPNFSDAIGK 403
            .|...||.:|.........|...:.|...........:||:......|...:|...|.|.:|||.
  Rat   962 VCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGD 1026

  Fly   404 CFSMAASSPRFLRKLGMLRDNKWKELPARLNRLYIQGLRVVFLLPVFYVLDRYRVEVLAGHI-KA 467
            ..:::.|:|:.|..|.:| .::.......:|.|....|..:..:|..|::|::|..|..|.| |.
  Rat  1027 VLALSVSTPKHLHSLNLL-SSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKE 1090

  Fly   468 DDNEAYWRLTELYTGAAAPTKRTNEQFDVPAKLLMEVDDQYASNFLSIVLQFQLLKHFCTITGQF 532
            :.|:.:|.|...|.|...|..|:...||..:|..:..:..|...|:|.::|||..:..|...|.
  Rat  1091 NYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGH- 1154

  Fly   533 EMGNPRKPLDMCDLSDQRGIGEILKRAMSLGSSVHYREVLKVLLGEPEISIDGLLTYFQPLQDWL 597
                 ..||..||:...:..|::|..||.||.|..:.|.:|::.|:|.:|...::.||:||.:||
  Rat  1155 -----TGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWL 1214

  Fly   598 QHQNQENNLEVGW 610
            ..:|:.:...:||
  Rat  1215 VTENRRHGETLGW 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-2	NP_788042.1	GluZincin	26..601	CDD:301352	149/581 (26%)
Ace	NP_036676.1	Peptidase M2 1	36..636
		Peptidase_M2	46..629	CDD:279709
		Peptidase M2 2	637..1238		154/598 (26%)
		Peptidase_M2	650..1227	CDD:279709	152/596 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880