DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-2 and acn-1

DIOPT Version :9

Sequence 1:	NP_788042.1	Gene:	Ance-2 / 34806	FlyBaseID:	FBgn0032535	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001024453.1	Gene:	acn-1 / 180780	WormBaseID:	WBGene00000039	Length:	906	Species:	Caenorhabditis elegans

Alignment Length:	724	Identity:	161/724 - (22%)
Similarity:	290/724 - (40%)	Gaps:	190/724 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VGLTQAGSQPD--------ATLERFL-------NETNQQLAVIYDQAVLAQLLN--------ELR 51
            |..|.|.:|||        ..::.||       |:||:  ..::...|...|:|        .|:
Worm   108 VAETAASTQPDELNTEVIEQLVDTFLNTGSIASNKTNK--GPVFANPVAQALVNSSNYWKTDNLQ 170

  Fly    52 GPNDL-----------------------VAL--------------LEIEVTDDKLVKYVRTLTTR 79
            .|..:                       |||              |.::..::.|..:||:.:.:
Worm   171 APGSIKDEEKLRSWLAGYEAEAIKVLREVALSGWRYFNDASPSLKLALDEAENVLTMFVRSTSMQ 235

  Fly    80 KAKFKRLGLGDSRQRRLLDKIPQLGYEALSGRDLKLVYALASSMSDNYHNVK-----------LC 133
            ..:|....:.|.:..|      ||||.:..|     :.|||.|...:|...:           :|
Worm   236 AKQFDMASVTDEKVMR------QLGYVSFEG-----MSALAPSRFADYSQAQAALNRDSKDSTIC 289

  Fly   134 AYKQPGNCTLRLIPEVQSIVQGSRDLDEIEYYWFEWRSRTGLA-TRSQFVDFMDLYKKTAQLNGY 197
            ....|..|.|:.| ::.||.:..:|...:::.|..:  .|.:| ::..:.:.:.:..:.|:|||:
Worm   290 DKDVPPPCALQKI-DMDSIFRNEKDASRLQHLWVSY--VTAIAKSKPSYNNIITISNEGAKLNGF 351

  Fly   198 PRAEDYWFRSLEL-----KGQETMN-LLDRIMHGLRPLFLQFHAHVRGSLRKMHGEHL-VPRNRP 255
            ......|..:.::     |.:..:| .:|:|...::|.:...||::|..|..::...: :.::.|
Worm   352 ANGGAMWRSAFDMSSKVHKAEFDLNKQIDKIYSTIQPFYQLLHAYMRRQLAGIYSNPVGLSKDGP 416

  Fly   256 YPQHLAEVFIGNAFRRVEAEWYV----------DLPSPEIGLANITQELHRRGLSTTQRVFWNVA 310
            .|.||.....|       .:|..          :..:||..|:....:.:     ||:::|....
Worm   417 IPAHLFGSLDG-------GDWSAHYEQTKPFEEESETPEAMLSAFNTQNY-----TTKKMFVTAY 469

  Fly   311 EYFRALGFPQLENSLWT---YAQKVSSD--------------DDDRCWHKAWRYYALPRTNFTYC 358
            .||::.|||.|..|.||   :|:..|.|              :|.|.  ||......|
Worm   470 RYFKSAGFPHLPKSYWTSSIFARVWSKDMICHPAAALDMRAPNDFRV--KACAQLGEP------- 525

  Fly   359 PLNDEERFFNMFEAQSDLQY-YRAASIQPTLLQEEPFPNFSDAIGKCFSMAASSPRFL--RKLGM 420
               |.|:..::. .|:..|| |:..|:   |.:|:..|..:|||...|:..:::|.:|  :||
Worm   526 ---DFEQAHSLL-VQTYYQYLYKDQSL---LFREQASPVITDAIANAFAHLSTNPHYLYSQKL-- 581

  Fly   421 LRDNKWKELPAR---------LNRLYIQGLRVVFLLPVFYVLDRYRVEVLAGHI-KADDNEAYWR 475
                    :|:.         :|:||.:.|.....||.....|.:|.|:..|.: |...|:.:|.
Worm   582 --------VPSEHLDIKDSVIINKLYKESLESFTKLPFTIAADNWRYELFDGTVPKNKLNDRWWE 638

  Fly   476 LTELYTGAAAPTKRTNEQFD-VPAKLLMEVDDQYASNFLSIVLQFQLLKHFC---TITGQFEMGN 536
            :...|.|..:|........| :....:.:|........:|.||:||:||..|   ||..
Worm   639 IRNKYEGVRSPQPYNTSNLDALIHNSVSQVHSPATRTLISYVLKFQILKALCPEGTILS------ 697

  Fly   537 PRKPLDMCDLSDQRGIGEILKRAMSLGSSVHYREVLKVLLGEPEISIDGLLTYFQPLQDWLQHQN 601
                 :.|.||:.  ..|.|:..|.||||:.:.:.|:::.|:.|:....||.|::||.:||::.|
Worm   698 -----EGCILSED--TTEKLRETMKLGSSITWLKALEMISGKGELDAQPLLEYYEPLINWLRNTN 755

  Fly   602 QENNLEVGW 610
            :.:.:.|||
Worm   756 EIDQVVVGW 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-2	NP_788042.1	GluZincin	26..601	CDD:301352	151/689 (22%)
acn-1	NP_001024453.1	Peptidase_M2	175..764	CDD:279709	143/653 (22%)
acn-1	NP_001024453.1	EB	<794..833	CDD:279949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960