DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-2 and ACE

DIOPT Version :9

Sequence 1:	NP_788042.1	Gene:	Ance-2 / 34806	FlyBaseID:	FBgn0032535	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_000780.1	Gene:	ACE / 1636	HGNCID:	2707	Length:	1306	Species:	Homo sapiens

Alignment Length:	660	Identity:	168/660 - (25%)
Similarity:	293/660 - (44%)	Gaps:	84/660 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LVGLTQAGSQP----DATLERFLNETNQQ-----------------------LAVIYDQAVLAQL 46
            :|||....:||    ...:.::|.|.|||                       :.::.|:|..::.
Human   588 MVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKF 652

  Fly    47 LNELRGPNDLV---------------------ALLE--IEVTDDKLVKYVRTLTTRKAKFKRLGL 88
            :.|....:.:|                     .||:  :::.:..| ||    .|:..||....|
Human   653 VEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTL-KY----GTQARKFDVNQL 712

  Fly    89 GDSRQRRLLDKIPQLGYEALSGRDLKLVYALASSMSDNYHNVKLCAYKQPGNCTLRLIPEVQSIV 153
            .::..:|::.|:..|...||..::|:....:...|...|....:|   .|....|:|.|::.:::
Human   713 QNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC---HPNGSCLQLEPDLTNVM 774

  Fly   154 QGSRDLDEIEYYWFEWRSRTGLATRSQFVDFMDLYKKTAQLNGYPRAEDYWFRSLELKGQETMNL 218
            ..||..:::.:.|..||.:.|.|....:..:::|..:.|:||||..|.|.| ||:    .||.:|
Human   775 ATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSW-RSM----YETPSL 834

  Fly   219 ---LDRIMHGLRPLFLQFHAHVRGSLRKMHGEHLVPRNRPYPQHLAEVFIGNAFRRVEAEWYVDL 280
               |:|:...|:||:|..||:||.:|.:.:|...:....|.|.||    :||.:.:..:..| ||
Human   835 EQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHL----LGNMWAQTWSNIY-DL 894

  Fly   281 --PSPEIGLANITQELHRRGLSTTQRVFWNVAEYFRALGFPQLENSLW--TYAQKVSSDDDDRCW 341
              |.|.....:.|:.:.::|. |.:|:|....::|.:||...:....|  :..:|.:...:..|.
Human   895 VVPFPSAPSMDTTEAMLKQGW-TPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCH 958

  Fly   342 HKAWRYYALPRTNFTYCPLNDEERFFNMFEAQSDLQYYRAASIQPTLLQEEPFPNFSDAIGKCFS 406
            ..||.:|.........|...:.|...........:||:......|..|:|...|.|.:|||...:
Human   959 ASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLA 1023

  Fly   407 MAASSPRFLRKLGMLRDNKWKELPARLNRLYIQGLRVVFLLPVFYVLDRYRVEVLAGHI-KADDN 470
            ::.|:|:.|..|.:|......: ...:|.|....|..:..:|..|::|::|..|..|.| |.:.|
Human  1024 LSVSTPKHLHSLNLLSSEGGSD-EHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYN 1087

  Fly   471 EAYWRLTELYTGAAAPTKRTNEQFDVPAKLLMEVDDQYASNFLSIVLQFQLLKHFCTITGQFEMG 535
            :.:|.|...|.|...|..||...||..||..:.....|...|:|.::|||..:..|...|.
Human  1088 QEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH---- 1148

  Fly   536 NPRKPLDMCDLSDQRGIGEILKRAMSLGSSVHYREVLKVLLGEPEISIDGLLTYFQPLQDWLQHQ 600
              ..||..||:...:..|:.|..||.||.|..:.|.::::.|:|.:|...:|:||:||.|||:.:
Human  1149 --TGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTE 1211

  Fly   601 NQENNLEVGW 610
            |:.:..::||
Human  1212 NELHGEKLGW 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-2	NP_788042.1	GluZincin	26..601	CDD:301352	160/628 (25%)
ACE	NP_000780.1	Peptidase M2 1	30..630		10/41 (24%)
		Peptidase_M2	40..623	CDD:279709	10/34 (29%)
		Peptidase M2 2	631..1232		158/617 (26%)
		Peptidase_M2	643..1221	CDD:279709	156/603 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.830