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Protein Alignment Ance and ACE2

DIOPT Version :9

Sequence 1:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001358344.1	Gene:	ACE2 / 59272	HGNCID:	13557	Length:	805	Species:	Homo sapiens

Alignment Length:	612	Identity:	223/612 - (36%)
Similarity:	345/612 - (56%)	Gaps:	22/612 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLATLAVTQALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKF 72
            ||:.:|||.|....|.|||.:|:..|.|........:.|:|.|.:|||:||.:..|....:.:.|
Human     8 LLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAF 72

  Fly    73 MKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKD 137
            :||.::....:..:..|:..:|.|.:||.:.|.:.|.||....|...|:.|.:.::..|||:..:
Human    73 LKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN 137

  Fly   138 STKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAE 202
            ..:| |.|:|.:.|:::.|.|:.|..:.|..:..:.|..:|..:|.||.|..:.|:.|::....:
Human   138 PQEC-LLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGD 201

  Fly   203 AWLDEYE-------DDTFEQQLEDI---FADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMH 257
            .|..:||       |.:..|.:||:   |.:|:|||:.:|.|||.:|...| .:.:|..|.:|.|
Human   202 YWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAH 265

  Fly   258 LLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDK 322
            |||:||.:.|:.:..:..||.:||.:||:..|..|.:...::|:..:.||.|:.|..:.|.||:.
Human   266 LLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330

  Fly   323 SIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRT 387
            |::..|.:.:..|||.:|||.. ..|.||..||:||.|...|.|||:|||||.:.|..|||:.|.
Human   331 SMLTDPGNVQKAVCHPTAWDLG-KGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRN 394

  Fly   388 GANPGFHEAVGDVLSLSVSTPKHLEKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKY 451
            |||.|||||||:::|||.:|||||:.||||. |:..|:|..||.|...||..:..|||.:.::|:
Human   395 GANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKW 459

  Fly   452 RWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQ 516
            ||.:|:||:.|..|...:|:::.|..|:..||...|...|..:.:|:|.|..::||....:.|||
Human   460 RWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQ 524

  Fly   517 FYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKA 581
            |.::.| :|.::     |.||..|||..|..||....|||.:|.|:||..|||...|.:.|:.:.
Human   525 FQEALC-QAAKH-----EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRP 583

  Fly   582 IAEYFEPLRVWLEAENIKNNVHIGWTT 608
            :..|||||..||:.:|  .|..:||:|
Human   584 LLNYFEPLFTWLKDQN--KNSFVGWST 608

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.