DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance and Ance-5

DIOPT Version :9

Sequence 1:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	170/635 - (26%)
Similarity:	309/635 - (48%)	Gaps:	33/635 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRL-FL-LALLATLAVTQALVKE--EIQAKEYLE----------NLNKELAKRTNVETEAAWAYG 51
            ||| || ::|:..|:||..:.:.  |:..|:.|:          :||:.:..:...:.::  ..|
  Fly     1 MRLPFLGVSLILLLSVTFGIGQSSYELATKQILDRAKDRMRHVWSLNRRIFVQLTAKGKS--PLG 63

  Fly    52 SNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAEL 116
            ..:.:    .|.|:.||..:...::|.:.:...........|:|:.:.:.||....|...||.:.
  Fly    64 GQVLN----SKLEVEAETYRLFYDLAGNLSVVSVAELNDPLLRRRVQRMAKLQLQGLRPKDYEQA 124

  Fly   117 LDTLSAMESNFAKVKVCDYKD-STKCDLALDPEIEEVISKSRDHEELAYYW----REFYDKAGTA 176
            .|.|..:.:......||.|:| |.:..||:.|:|......::.:|:|...|    |...:|  ..
  Fly   125 KDLLRQIHNFVNGPLVCPYEDCSARGSLAMYPQIMNKNMHTKLYEDLVINWKAWRRAINEK--DV 187

  Fly   177 VRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRK 241
            .::.|..||.|...||..|...:.:..|...|:.:.|:.::|.:..:|.|||:::|.|:|..::.
  Fly   188 AKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQAEMEAVVWEIMPLYRELHAYLRREVQA 252

  Fly   242 HYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFP--EKPLVDVSAEMEKQGYTPLKMFQMGD 304
            .|..|.....|.|...::..:.:|.|.......:|..  :..|..|...:|:...||:|:.:...
  Fly   253 AYPKADTKSDGAISAPIMDQILSQDWYPHQFFRTPHQGRQHQLPSVHRRLEEVLVTPVKINRKAA 317

  Fly   305 DFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHEL 369
            :||.|:.|..:|..|:|:.......:.....|.:..  :|...||.::.|.::...::..:|..:
  Fly   318 EFFESLGLMVMPNIFYDRFSRRMNDEEGGAECKSQV--YYFPPDVALRYCPKLDYKKMMQIHGTM 380

  Fly   370 GHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLT 434
            ..:||.|.....||...|...|||..|:.:.:.|:..||:||.::.:|.:....:|..:|:||..
  Fly   381 AELQYHLYKMQLPFGLDTEPCPGFGAAIAETVILASGTPRHLHRLHILLNDSLTEEQSLNRLFRM 445

  Fly   435 ALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYH-- 497
            .:..::.:|..|..||:...:..|.:...::|||:|.|:|:::|::||:.|..||||...|::
  Fly   446 GVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCAYWGLQDKFAGVQPPLQRLNKDFDVDFKFYRG 510

  Fly   498 ISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASK 562
            ::.:....:..::.|:.||||:|.|:.:|||.|.:...||.|||.|.|..||....:|:.:||::
  Fly   511 LNPETSNTKKFLAEILGFQFYRSFCLASGQYKPGDPNFPLHNCDFYDSKEAGKKIRDMMQLGATR 575

  Fly   563 PWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKC 612
            .|.|.:|...|||.:||:.|.|||.||..||:..|.:.::..||.....|
  Fly   576 HWRDVMEIATGERKLSGRGILEYFAPLFTWLKERNKQLDIEPGWDADELC 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	158/607 (26%)
Ance-5	NP_573392.2	GluZincin	93..610	CDD:301352	146/520 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800