Protein Alignment Ance and Ance-5

DIOPT Version :10

• Sequence 1: NP_477046.1
• Gene: Ance / 34805
• FlyBaseID: FBgn0012037
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_573392.2
• Gene: Ance-5 / 37980
• FlyBaseID: FBgn0035076
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 170/635 - (26%)
• Similarity: 309/635 - (48%)
• Gaps: 33/635 - (5%)

  Fly     1 MRL-FL-LALLATLAVTQALVKE--EIQAKEYLE----------NLNKELAKRTNVETEAAWAYG 51
            ||| || ::|:..|:||..:.:.  |:..|:.|:          :||:.:..:...:.::  ..|
  Fly     1 MRLPFLGVSLILLLSVTFGIGQSSYELATKQILDRAKDRMRHVWSLNRRIFVQLTAKGKS--PLG 63

  Fly    52 SNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAEL 116
            ..:.:    .|.|:.||..:...::|.:.:...........|:|:.:.:.||....|...||.:.
  Fly    64 GQVLN----SKLEVEAETYRLFYDLAGNLSVVSVAELNDPLLRRRVQRMAKLQLQGLRPKDYEQA 124

  Fly   117 LDTLSAMESNFAKVKVCDYKD-STKCDLALDPEIEEVISKSRDHEELAYYW----REFYDKAGTA 176
            .|.|..:.:......||.|:| |.:..||:.|:|......::.:|:|...|    |...:|  ..
  Fly   125 KDLLRQIHNFVNGPLVCPYEDCSARGSLAMYPQIMNKNMHTKLYEDLVINWKAWRRAINEK--DV 187

  Fly   177 VRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRK 241
            .::.|..||.|...||..|...:.:..|...|:.:.|:.::|.:..:|.|||:::|.|:|..::.
  Fly   188 AKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQAEMEAVVWEIMPLYRELHAYLRREVQA 252

  Fly   242 HYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFP--EKPLVDVSAEMEKQGYTPLKMFQMGD 304
            .|..|.....|.|...::..:.:|.|.......:|..  :..|..|...:|:...||:|:.:...
  Fly   253 AYPKADTKSDGAISAPIMDQILSQDWYPHQFFRTPHQGRQHQLPSVHRRLEEVLVTPVKINRKAA 317

  Fly   305 DFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHEL 369
            :||.|:.|..:|..|:|:.......:.....|.:..  :|...||.::.|.::...::..:|..:
  Fly   318 EFFESLGLMVMPNIFYDRFSRRMNDEEGGAECKSQV--YYFPPDVALRYCPKLDYKKMMQIHGTM 380

  Fly   370 GHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLT 434
            ..:||.|.....||...|...|||..|:.:.:.|:..||:||.::.:|.:....:|..:|:||..
  Fly   381 AELQYHLYKMQLPFGLDTEPCPGFGAAIAETVILASGTPRHLHRLHILLNDSLTEEQSLNRLFRM 445

  Fly   435 ALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYH-- 497
            .:..::.:|..|..||:...:..|.:...::|||:|.|:|:::|::||:.|..||||...|::
  Fly   446 GVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCAYWGLQDKFAGVQPPLQRLNKDFDVDFKFYRG 510

  Fly   498 ISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASK 562
            ::.:....:..::.|:.||||:|.|:.:|||.|.:...||.|||.|.|..||....:|:.:||::
  Fly   511 LNPETSNTKKFLAEILGFQFYRSFCLASGQYKPGDPNFPLHNCDFYDSKEAGKKIRDMMQLGATR 575

  Fly   563 PWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKC 612
            .|.|.:|...|||.:||:.|.|||.||..||:..|.:.::..||.....|
  Fly   576 HWRDVMEIATGERKLSGRGILEYFAPLFTWLKERNKQLDIEPGWDADELC 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_477046.1	Peptidase_M2	19..606	CDD:460196	158/607 (26%)
Ance-5	NP_573392.2	M2_ACE	67..610	CDD:341055	151/550 (27%)