DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance and Ance-4

DIOPT Version :9

Sequence 1:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_610442.2	Gene:	Ance-4 / 35909	FlyBaseID:	FBgn0033366	Length:	609	Species:	Drosophila melanogaster

Alignment Length:	639	Identity:	183/639 - (28%)
Similarity:	290/639 - (45%)	Gaps:	66/639 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFLLALLATLAVTQALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISA 67
            |.||.|:|.:....|....:::||.::...:....:..|  ..||..|.:|    ||:..:.:.:
  Fly     4 LLLLVLIAGIGCATAAANIDLEAKTFVNQSSDRYYRFYN--EIAAETYSAN----NEEDFDALFS 62

  Fly    68 ELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPE-----------DDYAELLDTLS 121
            :|.. :|.:|.:..... |...:.||.|.....||:   ||.|           |||      .|
  Fly    63 KLNN-VKRIAEELVSIS-RQAATYDLDRIRSPQTKM---ALQELRTAGDLFVLGDDY------FS 116

  Fly   122 AMESNFAKVKVCDYKDSTKCD-----------------LALDPEIEEVISKSRDHEELAYYWREF 169
            :::.|.|.::..    ||..|                 ||..|:|::::..|:|.:||.|||..:
  Fly   117 SVQMNLAALQTL----STDKDIEPYLGGANMPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAW 177

  Fly   170 YDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGY 234
            .||........|...|:...:|||:.. ....:.|. .|:.....||:|....::||.|||:|.:
  Fly   178 RDKNQLWASLNFYTIVQSYQRAAKILE-VPVHKLWY-RYDSQEMLQQMEQAMTELRPAYQQLHAF 240

  Fly   235 VRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKM 299
            ||..|.|.||..||:..||||.||...:..|.|:..:.:...:|...|.:....:..  .|...|
  Fly   241 VRQELHKKYGSDVVNLNGPIPDHLFQQVLEQAWASGSILEDYYPRAQLPEFDEYVSH--LTAKTM 303

  Fly   300 FQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFT 364
            ....::|:||:....|..:|....:.|...|..:..|..|.:|  ||..|.:..|.:|:..:|..
  Fly   304 VNESENFYTSLGFEPLSAEFHKNQLKEPNQDSPNDDCRPSIFD--LTPHVYLMYCEKVSFRKLMQ 366

  Fly   365 VHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARIN 429
            .|..:..:.|..|..|.|..|....|..|  |||:.:.||.|:|.||....|.|: |..:.|.::
  Fly   367 YHSHMARVYYAQQKSHLPSYYFKAYNLEF--AVGEAVVLSASSPAHLTGRRLAKE-VLSETALMS 428

  Fly   430 QLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPA 494
            :||..|:..|:.:|..:...|....|....||....|..:|:|.::::|||.|..|||...|.|.
  Fly   429 RLFRMAIHTILSIPLYYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQHAGIEAPSDRSEGAIDFPY 493

  Fly   495 KYHISADVEY-LRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSM 558
            |::::.|..: .:..:|.::.:|||:..|.|:  |:..    ||.|||.|||.|.|.....|:|:
  Fly   494 KFYVNIDQSFQTQKFISEVLGYQFYREFCKKS--YNRG----PLHNCDFYGSLAVGNDLKAMMSL 552

  Fly   559 GASKPWPDAL-EAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 611
            |::|||...: :.......:|..|:.||::|:..||...|...|..||||.|.|
  Fly   553 GSTKPWKQVVGKILPNNTGLSSLALLEYYQPVLDWLNKYNKDANSKIGWTASKK 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	172/616 (28%)
Ance-4	NP_610442.2	GluZincin	25..601	CDD:301352	172/611 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850