DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ance and Ance-3

DIOPT Version :9

Sequence 1:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001033904.1	Gene:	Ance-3 / 34808	FlyBaseID:	FBgn0032536	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	240/596 - (40%)
Similarity:	365/596 - (61%)	Gaps:	17/596 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QAKEYLENLNK------ELAKRTNVE----TEAAWAYGSNITDENEKKKNEISAELAKFMKEVAS 78
            |.:.|.:.|.|      |..::.::|    ..|.|.:.:|:.|..:.:.........:|.:..|.
  Fly   202 QDRRYQQELEKLRILLVESDQKGSLECTANVAAQWNFETNVNDFTQTEALNAQQRYVEFQRITAE 266

  Fly    79 DTTKFQWRSYQSEDLKRQFKALTKLGYAALP---EDDYAELLDTLSAMESNFAKVKVCDYKDSTK 140
            .:.:..........|.||....:::|..|||   .|.|..||:.:..:   :...::|.|:...:
  Fly   267 QSKRINKDLIFDRRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEMLFL---YNSAEICAYQQPFQ 328

  Fly   141 CDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWL 205
            |||...|:::::::||||.:||.:.|.|::.|||..:|..:|:.:::..:.|.:||.|:|.|.|.
  Fly   329 CDLHYIPQLKDIMAKSRDWDELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEYWY 393

  Fly   206 DEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEI 270
            ..||...|.|.::.::..|||||:.:|.|||.:||.:||...::...|||.|:||||:.|.||.:
  Fly   394 LAYESGNFRQDMDIVWEQIRPLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNV 458

  Fly   271 ADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLV 335
            .||:.|:|.:.|:||:..|.:|||||..|||:.::||||:|::.:..:|:..||.|:|.| |.::
  Fly   459 LDILIPYPGRKLIDVTPRMVEQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLD-RRVL 522

  Fly   336 CHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDV 400
            |..|||||....|.|:|.||.:.|..|.:||||:.||||||||:|.|.::|.||||.||:||||.
  Fly   523 CEPSAWDFCNRHDFRVKICTDINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDA 587

  Fly   401 LSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANW 465
            :.||||||:||:.:|||:..:.:....||.||..|:||:.|||||.::|.:|:.:|.|..:|...
  Fly   588 IGLSVSTPRHLQTLGLLQRSLDESSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTM 652

  Fly   466 NCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDP 530
            ||.:|.||::||||:|||:|||||||..|||||.|::.|::|..|.::|||.|:..|.::|||.|
  Fly   653 NCHYWNLREKYSGIKPPVLRSEKDFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVP 717

  Fly   531 DNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEA 595
            .:...||..||||...|||.....::|.|||:||.:.||....|..:.|.|:.|||.||..||..
  Fly   718 GDPRKPLHQCDIYRQPAAGNILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQ 782

  Fly   596 ENIKNNVHIGW 606
            ||::.|.::||
  Fly   783 ENLRTNEYVGW 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	238/594 (40%)
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:188999	231/571 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I1460
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2232
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.820