DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ance and Ace3

DIOPT Version :9

Sequence 1:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_006533116.1	Gene:	Ace3 / 217246	MGIID:	3644400	Length:	774	Species:	Mus musculus

Alignment Length:	604	Identity:	241/604 - (39%)
Similarity:	361/604 - (59%)	Gaps:	28/604 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWR 86
            |.|||.:|:...:......|...||.|.|.:|||.:|:|...:..|:.::||...::....|:..
Mouse    53 EAQAKLFLQFYEQTAQVVLNEFMEATWNYVTNITKQNQKNMLQKEADRSQFMLYFSTRARMFRTD 117

  Fly    87 SYQSEDLKRQFKALTKLGYAALPEDDYAELLD-------------------TLSAMESNFAKVKV 132
            .:.::|:||..:.|..:..:|||.:|..|:.|                   .|:.||:.:.:.:|
Mouse   118 HFLNQDVKRMLRKLQNIDKSALPTEDLLEVTDRGPGRPGTHTPAPERRYNRLLTYMETAYNRAEV 182

  Fly   133 CDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNF 197
            |  .|...| |.|:|:::|:::.|||.:||.:.|:.:.|..|..:|..||.||.|:.|||:.|.:
Mouse   183 C--LDEGPC-LTLEPDLQEIMATSRDQKELLWAWQGWRDAVGRQLRPVFEDYVRLSNKAAQYNGY 244

  Fly   198 TSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNM 262
            ......|..:||.||.|:.||.::.:::|||..:|.|||..|.::||..::...||||.||||||
Mouse   245 KDMGALWRSKYESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRGPIPAHLLGNM 309

  Fly   263 WAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEK 327
            |||.|:.|.|:|.|:|.|...|::|.|:.|.:.|.|||:..:.|||||.:...|..||.||::||
Mouse   310 WAQSWNNILDLVLPYPTKAPEDITAIMKIQHWRPEKMFEEANLFFTSMGMLPAPPAFWIKSMMEK 374

  Fly   328 PTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPG 392
            |.|||::.||.|:|:||..:|.|:|:||.||.:.|.:|.|::||||||||||:...:|:.||:|.
Mouse   375 PADGREVECHTSSWNFYKFNDFRVKKCTEVTLEDLLSVFHQMGHIQYFLQYQNLSVIYQEGASPA 439

  Fly   393 FHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFR 457
            |.||||.|::||||:.|:|...|||....:|.|..:|.|...||:||.|:||::.:||:||.:|.
Mouse   440 FEEAVGSVIALSVSSHKYLLARGLLSQPHQDSEEEVNFLLGIALEKIAFIPFSYLVDKFRWKIFD 504

  Fly   458 GEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSAC 522
            |.:.|..:|..:|..|.:|.|:.|||.||:.|||..||:||.|:|.|:||.:..|:|||.:::.|
Mouse   505 GTISKITYNQEWWNFRLKYQGLCPPVPRSDDDFDPGAKFHIPANVPYIRYFLGLILQFQLHEALC 569

  Fly   523 IKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFE 587
            ..:|...      ||..||.|.|..||....::|.:|:|:||.:.|:...||..:|.||...||:
Mouse   570 EASGHVG------PLHQCDNYNSKVAGKILGDLLKLGSSRPWREVLQEVTGESNISTKAFLTYFK 628

  Fly   588 PLRVWLEAENIKNNVHIGW 606
            ||..||..||:|....:||
Mouse   629 PLMDWLVTENVKQGDTLGW 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	239/602 (40%)
Ace3	XP_006533116.1	Peptidase_M2	51..647	CDD:366618	239/602 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835940
Domainoid	1	1.000	533	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H80337
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1397
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		mtm8699
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800