Protein Alignment Ance and Ace

DIOPT Version :10

• Sequence 1: NP_477046.1
• Gene: Ance / 34805
• FlyBaseID: FBgn0012037
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_997507.1
• Gene: Ace / 11421
• MGIID: 87874
• Length: 1312
• Species: Mus musculus
• Alignment Length: 593
• Identity: 260/593 - (43%)
• Similarity: 367/593 - (61%)
• Gaps: 9/593 - (1%)

  Fly    18 LVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTK 82
            |..:|.:|..::|..::......|...||.|.|.:|||.|..|...|.|.|::....:..:....
Mouse   647 LETDEAKADRFVEEYDRTAQVLLNEYAEANWQYNTNITIEGSKILLEKSTEVSNHTLKYGTRAKT 711

  Fly    83 FQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDP 147
            |...::|:..:||..|.|..|..|.||..:..|....|..||:.::...:| |.:.| | :.|:|
Mouse   712 FDVSNFQNSSIKRIIKKLQNLDRAVLPPKELEEYNQILLDMETTYSLSNIC-YTNGT-C-MPLEP 773

  Fly   148 EIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDT 212
            ::..:::.||.:|||.:.|:.:.||.|.|:...|.:|||.:.|.||||.:|...::|...||.|.
Mouse   774 DLTNMMATSRKYEELLWAWKSWRDKVGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSLYESDN 838

  Fly   213 FEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF 277
            .||.||.::.:::|||..:|.|||..|.:|||...::..||||.|||||||||.||.|.|:|:||
Mouse   839 LEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPF 903

  Fly   278 PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWD 342
            |..|.:|.:..|.|||:||.::|:..|:||||:.|..:|.:||:||::|||||||::|||.||||
Mouse   904 PSAPNIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWD 968

  Fly   343 FYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVST 407
            ||...|.||||||.|..:.|...|||:||||||:||:..|..:|.|||||||||:||:::|||||
Mouse   969 FYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALSVST 1033

  Fly   408 PKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKL 472
            ||||..:.||.......|..||.|...|||||.|:||::.:|::||.:|.|.:.|.|:|..:|.|
Mouse  1034 PKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSL 1098

  Fly   473 RDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPL 537
            |.:|.|:.|||.||:.|||..:|:|:.|:|.|:||.|||||||||:::.|..||...      ||
Mouse  1099 RLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEALCRAAGHTG------PL 1157

  Fly   538 DNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNV 602
            ..||||.|..||....:.:.:|.|||||:|::...|:..||..|:..||:||..||..||.::..
Mouse  1158 HKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGE 1222

  Fly   603 HIGWTTSN 610
            .:||...|
Mouse  1223 TLGWPEYN 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_477046.1	Peptidase_M2	19..606	CDD:460196	256/586 (44%)
Ace	NP_997507.1	Peptidase_M2	45..628	CDD:460196
		Peptidase_M2	649..1226	CDD:460196	256/585 (44%)
		Juxtamembrane stalk. /evidence=ECO:0000250|UniProtKB:P12821	1220..1261		3/11 (27%)