DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance and ace

DIOPT Version :9

Sequence 1:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001116882.1	Gene:	ace / 100144634	XenbaseID:	XB-GENE-479789	Length:	1284	Species:	Xenopus tropicalis

Alignment Length:	594	Identity:	270/594 - (45%)
Similarity:	380/594 - (63%)	Gaps:	13/594 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKF 83
            :..|.:|..:|.:..|......|..|||:|||.:|||:.|::...:.:..::....:.......:
Frog   631 IANEKEADTFLSDYTKSAEVVWNDYTEASWAYNTNITEANKQVMLDKNLAMSGHTLQYGLQARNY 695

  Fly    84 QWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKD-STKCDLALDP 147
            .:..:|..:.:|..:.|:::..|||.|::..|.....|.||:.::..|||  || :|.|. .|||
Frog   696 DYSDFQDPETQRILRKLSEIDKAALSEEEQKEYNQITSDMETIYSVAKVC--KDGNTNCH-PLDP 757

  Fly   148 EIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDT 212
            ::.|:::||||::||.:.|:.:.|.:|..:|.:::|||:|..|||:||.:......|...||..|
Frog   758 DLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAYWRSWYETPT 822

  Fly   213 FEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF 277
            .|..:|.::.:::|||..:|.|||..|.|.|||..::..||||.|||||||||.||.|.:::.|:
Frog   823 LESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLVPY 887

  Fly   278 PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWD 342
            |....||.:..|..:.:||.:||:..|:||.|:.|..:||:|||||:||||.| |::||||||||
Frog   888 PNAAQVDATPAMIAKNWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKD-REVVCHASAWD 951

  Fly   343 FYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVST 407
            ||...|.||||||.|..|.|.|||||:||:||||||:.||.::|.|||||||||:||||:|||||
Frog   952 FYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVST 1016

  Fly   408 PKHLEKIGLLKDYVRDD-EARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWK 471
            ||||:.|||| |.|.|: |:.||.|...|||||.||||.|.||::||.:|.|....:.:|..:|.
Frog  1017 PKHLQSIGLL-DKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWN 1080

  Fly   472 LRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELP 536
            ||.:|.|:.|||:|:|.|||..||:||.|.|.|:||.:||:|||||:::.|..|.|      |.|
Frog  1081 LRLKYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQ------EGP 1139

  Fly   537 LDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNN 601
            |..||||.|..||....:.:.:|.|||||:|::...|:|.||..|:.:||:||..||..||.||.
Frog  1140 LHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNG 1204

  Fly   602 VHIGWTTSN 610
            ..:||...|
Frog  1205 ETLGWPEYN 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	267/588 (45%)
ace	NP_001116882.1	Peptidase_M2	28..611	CDD:279709
ace	NP_001116882.1	Peptidase_M2	631..1209	CDD:279709	267/588 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	546	1.000	Domainoid score	I258
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm47533
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1436
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010