DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and EST1

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_013334.1	Gene:	EST1 / 850934	SGDID:	S000004223	Length:	699	Species:	Saccharomyces cerevisiae

Alignment Length:	270	Identity:	49/270 - (18%)
Similarity:	98/270 - (36%)	Gaps:	79/270 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 DNEDVVIEEEKIVYPN---EVERRSNSQEADSEELLRSFE-----VLQLNFKSAEDAQSKPVAPP 675
            |||:|..|..::.:.|   .:::...|:....|....:|.     :.:.:.:..|:...|
Yeast     2 DNEEVNEECMRLFFKNARAHLDKHLTSRLTCDENAYITFRCFLDGIHRKSTRFLEELLLK----- 61

  Fly   676 PVSFSEPPKKLVYRNKYTKINPNIVIDCLHNEPTIRALKMLFDWLRINPEILIGCYHSNPEFVHK 740
                   .:.:.:.|.|.:||.:::       |.:  ||:|  ||:|:...|....|    :.|.
Yeast    62 -------QENMYHNNNYERINDSVI-------PLV--LKLL--WLQIHEPTLQWFEH----WFHD 104

  Fly   741 IMKLLNYCNIDIF-------------TRKVYFERDLLTTANVRDSLVELFDVRANVPLTEDFAFK 792
            ||:|.|.....:|             |.:.|::        :.:.|...:|:.:   :..:..|.
Yeast   105 IMRLSNRRKFRVFRIFQKKMIQFFKITHRYYYD--------IIEHLCAKYDMNS---VISNALFA 158

  Fly   793 NFDIFQSTQITLDWETIIRERVTPQEESILRIFKMVDFGFFICKQKKFNYRFCV---KTRRFTET 854
            ..::.|.|           :.::..|:.||.....:.|...|..|:      ||   .:..|.:|
Yeast   159 KLNLMQYT-----------DGLSTHEKIILNTSNPLTFSIVISLQR------CVINLGSTHFYKT 206

  Fly   855 QKKKQREEKK 864
            ...|...:.|
Yeast   207 LLNKPSNKPK 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360
		EST1_DNA_bind	240..478	CDD:287359
		PIN_Smg5	1012..1173	CDD:189054
EST1	NP_013334.1	EST1	82..209	CDD:402133	31/162 (19%)
EST1	NP_013334.1	EST1_DNA_bind	224..508	CDD:402132
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15696
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000