DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and smg5

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001072622.1	Gene:	smg5 / 780078	XenbaseID:	XB-GENE-5905793	Length:	1036	Species:	Xenopus tropicalis

Alignment Length:	1254	Identity:	291/1254 - (23%)
Similarity:	482/1254 - (38%)	Gaps:	361/1254 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KDLYRSLYTASKQLDDAKRNVQSVGQLFQHEIEEKRSLLVQLCKQIIFKDYQSVGKKVREVMWRR 107
            |.|||::.....:||....|..:..::|:.|....|:.|.:||.:::|......|:|..||:||:
Frog    18 KRLYRAVVETVHRLDLIISNKSAYQEVFKPENISLRNKLRELCVKLMFLHPVEYGRKAEEVLWRK 82

  Fly   108 GYYEFIAFVKKNWHKQCQDAATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSII 172
            .|||.|..:|.|  |:...:.:|.|...:..  |.||:..|:.|...::..|.|:|:..||::.:
Frog    83 VYYEVIQLIKTN--KKHIHSRSALECAYRTH--LIAGVGFYQHLLLYIQSHYQLELQCCIDWTHV 143

  Fly   173 SDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKE 237
            :|    .:||        ....|..|.:.:.:|....|..|:.||||.||..:..:     :..|
Frog   144 TD----PLIG--------FKKPVSASTKEMDWARMACHRCLVYLGDLARYQNELAV-----VDTE 191

  Fly   238 QVA-KYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLF--- 298
            ::| ::|.:|..::|.:||..||||||...:.:.:|:||.||..:...:.||.:..||.:|:
Frog   192 KLAERFYCQALTVDPTVGMPFNQLGTLAGSKYYHVDATYCYLRCIQSDVSFEGAYGNLKRLYDKA 256

  Fly   299 AKHTEYLERMDPEKLD------FNIEDFFARFYLIVDIFFFDKEVP-------DFNALCHCVLID 350
            ||....|::.:..||.      .:|:.....|..:..:.     .|       :..:||..||.|
Frog   257 AKMYHQLKKSESRKLSPSKKRCKDIKRLLVSFLHLQSLM-----QPKSSSIEAELTSLCQSVLED 316

  Fly   351 LRKILCSQQLR---------------------VPEPSIFKIVSILFFCLSKLKMINSPKVYSLHA 394
            ..  ||...:.                     :|:..:|::|.|....:..||..:|.:..:..|
Frog   317 FN--LCMFYMPTSLNMSSASEDEEEYEGGYSFLPDLLVFRMVVICLMSVHSLKRADSKQYSAAIA 379

  Fly   395 FLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGECER 459
            |.:|..|.|::              ..|.|.|||.||
Frog   380 FTLALFSHLVN--------------HVNIRLQAELEE---------------------------- 402

  Fly   460 KDKKLMPRPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAV--STRSSDEAKESDLKTPLSC 522
                 .|.| :.|:.|.|..||:...|..    ..|.|...|..  .||.....|.:..|   |.
Frog   403 -----SPLP-AFKNDSPDDHDSKEVSEVI----VKDADPEPEMAQNQTRKQQRTKSNSKK---SH 454

  Fly   523 KSKRRGMRLRRRR--RKIAQSDDSSCYDSESELDT----------DFYSDEEDYTDLSSNFD--- 572
            |..|.. ||||||  ||:.:||.|..:||:|...:          ...||||...|:.::.|
Frog   455 KYSRLS-RLRRRRHARKLDESDLSEGFDSDSSRGSAKGSDISESGSEKSDEEAAFDVETDSDMNS 518

  Fly   573 ----TDFSDIDAADPGEPCG--EERYAAANYSKKE--RKAGGGGGGGVGGVVYSDNEDVVIE--- 626
                :|..|:: .||.|..|  |.:.|..|.::::  :.|....|         ::::|.|.
Frog   519 QESRSDLEDME-DDPYERKGIREPKDALKNPTEEQDAKMAASTKG---------ESQEVPINGPC 573

  Fly   627 ----EEKIVYPNEVERRSNSQEADSE--ELLRSFEVLQLNFKSAEDAQSKPVAPPPVSFSEPPKK 685
                |..|.        ||.|...|:  :..|.|.:.    .:..:...||.|.|....:|.|..
Frog   574 PASGEGSIA--------SNLQAMSSQMFQTKRCFRLA----PTFTNVLVKPAAEPANPTAEVPTP 626

  Fly   686 LV---------------------------YRNKYTKINPNIVIDCLHNEPTIRALKMLFDWLRIN 723
            ||                           .||:.|....   ::.:.:|..:..:|:..||||.|
Frog   627 LVNGDTEKQNSVEQEDGSDSEESMLSSKSCRNEKTLQER---LEIITSEGLLVTVKIFLDWLRAN 688

  Fly   724 PEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTA------------NVRDSLV-- 774
            .:|:|.|..|:....:::..|||                ||.:|            .||:.|:
Frog   689 TDIVIMCAQSSQSLWNRLSVLLN----------------LLPSAPKIQEAGIPLSNEVRNLLMDS 737

  Fly   775 ELFDVRANVPLTEDFAFKNFDIFQSTQITLDWETIIRER--VTPQEESILRIFKMVDFGFFICKQ 837
            ||.|:.:::.|.||.|.:.....:.....:::|   :||  :|..|||:.|...:..||.|:
Frog   738 ELPDINSHLLLPEDAALRYLPPLRPAHRKINFE---QERPALTVLEESVARSCYIRSFGHFL--- 796

  Fly   838 KKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRTRRYSDRKNGIVRK 902
                                                         .|.:|....::
Frog   797 ---------------------------------------------TRLQGNVLHFN--------- 807

  Fly   903 SYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATGTSVAGGTSASTTTNSVIEKLNLQSS 967
                             |..|..                 ||:     |....::::.:...|..
Frog   808 -----------------PELGIF-----------------TSI-----AEPGHDNILHQAQAQFR 833

  Fly   968 SGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSPFVVVDSKALTEYNGIVKSLV 1032
            ...:|.|   :::....|.:|.||.||..||..|:...|...|||::|.|::||.::.|:::.|.
Frog   834 MAQEEAR---RNRLMRDMAQLRLQLEVSQLEGTLQQPKAQSAMSPYLVPDTQALCQHLGVIRQLA 895

  Fly  1033 RTKKCIVLIPNAVLNELDDLKKRSENVRHVIRWLEQEFKQGNRHLRAQRD-NESQPLSLLKISRK 1096
            .:.:.|::||..|::.||.|||.:...|..||:||.|||:|||::|.||: .:|...:.||   :
Frog   896 TSGRFILIIPRTVIDGLDFLKKENAGARDGIRYLEAEFKKGNRYIRCQRETGKSYEKNKLK---R 957

  Fly  1097 MDRDASVFLQIAQFCNHLVANHA--DPHVSELQKSVVTYLSGDNLHEKNRQQQNFS---YTGI-- 1154
            .|.||....:|...|..|..:..  |...:    .:||.::|..|.:..    :||   .|.:
Frog   958 QDTDAWHLYKILDSCKQLTVSQGGNDDDTA----GMVTIITGFQLSDSG----SFSPAMQTALQT 1014

  Fly  1155 LDSIPVRYAQIQSFYAKFK 1173
            ..|..:....:..||.::|
Frog  1015 ASSANIEIKNVLEFYRQWK 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	36/122 (30%)
		EST1_DNA_bind	240..478	CDD:287359	60/275 (22%)
		PIN_Smg5	1012..1173	CDD:189054	50/168 (30%)
smg5	NP_001072622.1	EST1	74..185	CDD:371012	38/126 (30%)
		TPR repeat	169..203	CDD:276809	12/38 (32%)
		EST1_DNA_bind	194..>409	CDD:371011	58/269 (22%)
		TPR repeat	208..238	CDD:276809	13/29 (45%)
		TPR repeat	243..265	CDD:276809	7/21 (33%)
		Nop14	<472..>576	CDD:367841	25/113 (22%)
		PIN_Smg5-like	875..1033	CDD:350232	50/168 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10028
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3477
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102776at33208
OrthoFinder	1	1.000	-	-		FOG0008183
OrthoInspector	1	1.000	-	-		oto104443
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060