Protein Alignment Smg5 and Smg6

DIOPT Version :9

• Sequence 1: NP_001285914.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Sequence 2: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Alignment Length: 851
• Identity: 171/851 - (20%)
• Similarity: 286/851 - (33%)
• Gaps: 243/851 - (28%)

  Fly   119 NW------HKQCQDAATAQENMQKLERFLCA-------------GIFNY-KRLSARMEEIYDLDL 163
            ||      |.|.|| |..|..:::| :|:|.             .:.|| ||........:.|
  Fly   189 NWKNFCYIHDQLQD-AFKQLLLEQL-KFVCEHKVDVFFWKLLFYNVRNYLKRQQTDQAHTHTL-- 249

  Fly   164 KYLIDFSIISDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRI 228
             .||:.:|    ....|:.|.:.:....:...|.:|:.|:..|      |:.||||.||    |:
  Fly   250 -LLIEQAI----KFYRMLYDKLMAKCVASSRCDSALKVVAQRL------LICLGDLTRY----RV 299

  Fly   229 DSKLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENN 293
            :...:....:.|:||..|.:|.|..|...|||..:....:...|:.|:|:.||:.....:.::.:
  Fly   300 NHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKES 364

  Fly   294 LNKLF------------------------------------------------------------ 298
            |..||
  Fly   365 LLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKGNKAKGNKA 429

  Fly   299 --AKHTEYLERMDPEKLDFNIEDFFARFYLIVDIFFFDKEVPDFNALCHCVLIDLRKILCSQQLR 361
              |:...| |.|.||::...|...:  .||:..: :...:|.....|...:.|.:...|..:.|
  Fly   430 TMAEVNRY-EEMPPEEILPRIVSLY--LYLLGKL-YTGTDVDSLYPLLRKLQIQIGVALRHENL- 489

  Fly   362 VPEPSIFKIVSILFFCLSKLKMINSPKVYSLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQ 426
            :....:.|||::..|.:...|...|.:....|:|..|  :......:....|.:....:|:...|
  Fly   490 LSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFNFA--NSFFGLMMKKTNQLLAGFVEDSTNVQ 552

  Fly   427 AEYEERFQEFDTVVRKSRNEYKNWLAA---VGECERKDKKLMPRPHSLKDCSS---------DSR 479
            ...||.|...:|.: :..|.|..||:.   |.|..|.::      ||..||.:         :..
  Fly   553 CLPEEDFATVNTYL-QFVNVYVRWLSISLDVWEPVRSEE------HSFIDCWAELTILFEYIECL 610

  Fly   480 DSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKS------KRRGMRLR--RRRR 536
            ..:|..|  |.:...|.|     |:.|..         |||..::      ||...||:  .|.|
  Fly   611 MGKHKLE--KNEILLDED-----VALRGF---------TPLGRETLSMDYLKRGSERLQFFERVR 659

  Fly   537 KIAQSDDSSCYDSES---ELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGEERYAAANYS 598
            :|.|..:......|:   .|::.|..:.     |::.......:.||    |.||    .|||.|
  Fly   660 RIGQFQEYYVQHQEALQQPLESSFTVEH-----LNAAMKNALENYDA----ESCG----LAANVS 711

  Fly   599 KKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSFEVLQLNFKS 663
            |.:.||                    :|          |....|.::|..||.:..:.|:...:.
  Fly   712 KIQCKA--------------------VE----------ELLCRSTDSDVSELCKLKKELEAKARV 746

  Fly   664 AEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINP-------NIVIDCLHNEPTIRALKMLFD-WL 720
            .:...||         .|...|.|....|.::.|       |..||||.:   ...|...|. :.
  Fly   747 KQICTSK---------LEDILKFVDTKIYIEVRPRYLLPDTNCFIDCLED---FEKLSTEFKRYT 799

  Fly   721 RINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVELFDVRANVP- 784
            .|.|..::    ...:.:.|.:||.:|.:.....|..:|:.   .::..:.||..:...:.||.
  Fly   800 LIIPLTVV----KELDGLSKGVKLDSYRSSKQTQRIHHFDE---VSSRAKKSLEFIKSAKGNVKC 857

  Fly   785 LTEDFAFKNFDIFQSTQITLDWETIIRERVTPQEESILRIFKMVDFGFFICKQKKFNYRFCVKTR 849
            .|...:|.|..:|          .::.|.....::.||.....|        .|......|...:
  Fly   858 ATTKGSFVNASVF----------ALVEEEYLSNDDKILATAMAV--------SKTAKTEQCTDGK 904

  Fly   850 RFTETQ 855
            .|.:|:
  Fly   905 CFIQTE 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	30/122 (25%)
		EST1_DNA_bind	240..478	CDD:287359	59/311 (19%)
		PIN_Smg5	1012..1173	CDD:189054
Smg6	NP_651321.1	EST1	190..298	CDD:287360	31/126 (25%)
		EST1_DNA_bind	310..638	CDD:287359	69/357 (19%)
		P-loop_NTPase	<616..>769	CDD:304359	46/220 (21%)
		PIN_Smg6	767..941	CDD:189055	32/172 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR15696
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000