DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and smg7

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_012816221.1	Gene:	smg7 / 394870	XenbaseID:	XB-GENE-955255	Length:	1193	Species:	Xenopus tropicalis

Alignment Length:	823	Identity:	159/823 - (19%)
Similarity:	269/823 - (32%)	Gaps:	286/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EIEEKRSLLVQLCKQIIFKDYQ-SVGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQENMQK 136
            |:...|..|..|.::::..|.: ::.|||.:.:|...:        ||.....|..|..:.|..:
Frog    28 EVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAF--------KNQITTLQGQAKNRTNPNR 84

  Fly   137 ------LERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSIISDGYISDMIGDTMESSHSGTHAV 195
                  |..||.|....|.:|...:..::::||...:..|.:  |.||:      :..||||...
Frog    85 SEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQL--GIISN------KQMHSGTVVK 141

  Fly   196 DKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQL 260
            .:|    |.........|:.|||:.||          .....|...||..|.:|.|:.|...|||
Frog   142 PQS----SSCAYICQHCLVHLGDIARY----------RNQTSQAESYYRHAAQLVPSNGQPYNQL 192

  Fly   261 GTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLFAKHTEYLERMDPEKLDFNIEDFFARF- 324
            ..|...:...|.:.::|..|:....||..:..||.|..:|   .||..:..|..:.:.||...|
Frog   193 AILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSK---ALESREEVKNRWGVSDFIKAFI 254

  Fly   325 ------YLIVDI----------------FFFDKEVPDFNALCHCVLIDLRKI------------- 354
                  ||...:                ..|.|.: :...|.|..:|:|.::
Frog   255 KFHGHVYLTKSLEKVSTLREQLEEQFKNLLFQKAL-NSQQLVHITVINLFQLHHLRSFGTEADQQ 318

  Fly   355 -------LCSQQL------------RVP---------------------------EPSIFK---- 369
                   ||..||            |.|                           .||:|:
Frog   319 SFSPEEELCWSQLLALFMSFLGILCRFPLKTHHCEETSCANPLPAIKVSLDWMKLRPSVFQENTV 383

  Fly   370 ---------IVSIL--FFCL----SKLKMINSPKVYSLHAFLV--------------AACSDLMD 405
                     ::|:|  |..|    |...|:..|:.:.|..||.              .|.:.:.|
Frog   384 EEKKYVWPWLISLLNSFHVLDEDVSSANMLPLPEEFELQGFLALRPAFRNLDFSRGHQAITGVRD 448

  Fly   406 ACIVSIEQTILARA----QDNERFQAEY------------------------EER-----FQEFD 437
            |....:....||..    .:|:....:|                        |:|     |.:.|
Frog   449 AQHRQLRPLRLAAVGKWISENQPQLIQYRTVEGELLFFTDIPELLTEDIDETEDRSSPQEFNQTD 513

  Fly   438 TVVRKSRNEYKNWLAAVG---ECERKDKKLMPRPHSLK--DCSSD--SRDSQHSGEEAKTQEAAD 495
            |...:.....|:.| :.|   .|:..:|.::....::|  :.:.|  ||....||..||.|.  |
Frog   514 THKAEGSPGLKSVL-STGRSLSCDTNEKPVVTFKENIKPQELNRDVPSRSYTRSGNVAKDQR--D 575

  Fly   496 GDK-IGEAVSTRSSDEAKESDLKTPLSCKSKRRGMR-----------LRR----RRRKIAQSDDS 544
            .:| :..||:.:.::..::::||.....|:...|.:           ||:    ..||.|.:..|
Frog   576 YNKSLNNAVNKKDNNNKRKNELKKMCVEKTAEPGKQSIAVQVKSQTELRKTPVSEARKTAVTPTS 640

  Fly   545 SCYDSESELDTDF------------------------------YSDEEDYT-----DLSSNFDTD 574
            |...|     |.|                              :|....|:     ::..:|...
Frog   641 SPSSS-----TQFIPIHHPGAFPPLPSRPGFPPPAYVIPPPVAFSMSSGYSFPAGVNVPGSFLQP 700

  Fly   575 FSDIDAADPGEPCGEERYAAANYSKKERKAG------GGGGGGVGGVVYSDNEDVVIEEEKIVYP 633
            .|...:.:.|.| |::.:..  || ::|.:|      |..|..:.|.:...            .|
Frog   701 SSHSPSGNQGPP-GKQSHIP--YS-QQRPSGPVTPNQGNLGNQITGQIQPQ------------AP 749

  Fly   634 NEVERRSNSQEADSEELLRSFEVLQLNFKSAEDAQSKPVAPPP 676
            :....:|:||.|..         ||:...:.:.:.:||:...|
Frog   750 SNSPTQSSSQTAAQ---------LQIQALAQQQSPTKPIQSIP 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	30/128 (23%)
		EST1_DNA_bind	240..478	CDD:287359	71/392 (18%)
		PIN_Smg5	1012..1173	CDD:189054
smg7	XP_012816221.1	EST1	55..167	CDD:287360	32/141 (23%)
		TPR repeat	154..180	CDD:276809	10/35 (29%)
		EST1_DNA_bind	171..431	CDD:287359	52/263 (20%)
		TPR repeat	185..215	CDD:276809	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102776at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010