Protein Alignment Smg5 and Smg7

DIOPT Version :9

• Sequence 1: NP_001285914.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Sequence 2: XP_006250067.1
• Gene: Smg7 / 360855
• RGDID: 1310761
• Length: 1212
• Species: Rattus norvegicus
• Alignment Length: 650
• Identity: 130/650 - (20%)
• Similarity: 217/650 - (33%)
• Gaps: 204/650 - (31%)

  Fly    73 EIEEKRSLLVQLCKQIIFKDYQ-SVGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQENMQK 136
            |:...|..|..|.::::..|.: ::.|||.:.:|...:        ||.....|..|..:.|..:
  Rat    53 EVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAF--------KNQITTLQGQAKNRANPNR 109

  Fly   137 ------LERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSIISDGYISDMIGDTMESSHSGTHAV 195
                  |..||.|....|.:|...:..::::||...:..|.:  |.||:      :.:|  |.|:
  Rat   110 SEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQL--GIISN------KQTH--TSAI 164

  Fly   196 DKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQL 260
            .|. ::.|.:....| .|:.|||:.||          .....|...||..|.:|.|:.|...|||
  Rat   165 VKP-QSSSCSYICQH-CLVHLGDIARY----------RNQTSQAESYYRHAAQLVPSNGQPYNQL 217

  Fly   261 GTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLFAKHTEYLERMDPEKLDFNIEDFFARFY 325
            ..|...:...|.:.::|..|:....||..:..||.|..:|   .||..|..|..:.:.||...|.
  Rat   218 AILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSK---ALESRDELKTKWGVSDFIKAFI 279

  Fly   326 LIVDIFFFDKEVPDFNALCHCVLIDLRKILCSQQLRVPEPSIFKIVSILFFCLSKLKMINSPKVY 390
            ......:..|.:..        |..||:.|..|         ||  .:||     .|..||
  Rat   280 KFHGHVYLSKSLEK--------LSPLREKLEEQ---------FK--RLLF-----QKAFNS---- 316

  Fly   391 SLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEE-----------RFQEFDTVV---- 440
                      ..|:...::::.|....|...||..|..|.:           .|..|..::
  Rat   317 ----------QQLVHVTVINLFQLHHLRDFSNETEQHSYSQDEQLCWTQLLALFMSFLGILCKCP 371

  Fly   441 -----RKSRNEY--------KNWLAAVGECERKDKKLMPRPHSLKDCSSDSR-----------DS 481
                 ::|.|.|        .:||..             ||...::...|.|           :|
  Rat   372 LQNDSQESYNAYPLPAVKVSMDWLRL-------------RPRVFQEAVVDERQYIWPWLISLLNS 423

  Fly   482 QHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKSKRRGM----------------- 529
            .|..|:             :..||.::...:|.:|:..|:.:...|.:
  Rat   424 FHPRED-------------DLSSTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQ 475

  Fly   530 -RLRRRR-----RKIAQSDDS--SCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEP 586
             |:|::|     :.||.:...  .|.:...:|                .|.|:..::...||.|
  Rat   476 RRIRQQRLISIGKWIADNQPRLIQCENEVGKL----------------LFITEIPELILEDPSE- 523

  Fly   587 CGEERYAAANYSKKERKA----GGGGGGGVGGVVYS---------DNEDVVIEEEKIVYPNEVER 638
                  |..|...:|..|    ...|..|:..|:.:         ..|..|:..::.:.|.||.|
  Rat   524 ------AKENLILQETSAIESHASDGSPGLKSVLSTGRSPSTSCDSGEKPVVTFKENIKPREVNR 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	30/128 (23%)
		EST1_DNA_bind	240..478	CDD:287359	55/265 (21%)
		PIN_Smg5	1012..1173	CDD:189054
Smg7	XP_006250067.1	EST1	80..192	CDD:402133	32/141 (23%)
		TPR repeat	179..205	CDD:276809	10/35 (29%)
		EST1_DNA_bind	196..455	CDD:402132	65/325 (20%)
		TPR repeat	210..240	CDD:276809	8/29 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102776at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910