DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and Smg6

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001099278.1	Gene:	Smg6 / 287522	RGDID:	1595918	Length:	1472	Species:	Rattus norvegicus

Alignment Length:	1224	Identity:	212/1224 - (17%)
Similarity:	382/1224 - (31%)	Gaps:	473/1224 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ILSQEVKDLYRSLYTASK---QLDD--AKRNVQSVGQLFQHEIEEKRSLLVQLCKQIIFKDYQ-S 95
            :.:.:.::|:|.|..|..   ||.:  ::..:.:.|   ..::.:.|:.|:||.::.|..|.: |
  Rat   626 VRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEG---MEKMAQLRTELLQLYERCILLDIEFS 687

  Fly    96 VGKKVREVMWRRGYYEFIAFVKKNWHKQCQD--AATAQENMQKLERFLCAGIFNYKRLSARMEEI 158
            ..:.|.:::|:..:|:.|    :.:.:..:|  ....::...:|...|..|...:..|..:::..
  Rat   688 DSQNVDQILWKNAFYQVI----EKFRQLLKDPNIENPEQIRNRLLELLDEGSDFFDSLLQKLQVT 748

  Fly   159 YDLDLKYLIDFSIISDGYISDMIGDTMESSHSGTHAVDKSL-EAVSFALDTIHSSLLSLGDLHRY 222
            |...|:..:|                      |.....|.| :.|.:||.:...|::..||:.||
  Rat   749 YKFKLEDYMD----------------------GLAIRSKPLRKTVKYALISAQRSMICQGDISRY 791

  Fly   223 FLDFRIDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPF 287
                |..:..:.:..:...:||:|..:.|..|...|||..|.......||:.|:|:.||....|.
  Rat   792 ----REQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPI 852

  Fly   288 ELSENNLNKLF---AKHTEYLERMDPEKLDFNIEDFFARFYLIVDIFFFDKEVPDFNALCHCVLI 349
            ..::.:|..||   .:..|.:|:...|:.|.:                     ||
  Rat   853 LTAKESLMSLFEETKRKAEQMEKKQHEEFDLS---------------------PD---------- 886

  Fly   350 DLRKILCSQQLRVPEPSIFKIVSILFFCLSKLKMINSPK-------------------VYSLHAF 395
                     |.|..:.|.|:.|.   ...::|::...|.                   :.||
  Rat   887 ---------QWRKGKKSTFRHVG---DDTTRLEIWIHPSHSRSSQGTESGKDSEQENGLGSL--- 936

  Fly   396 LVAACSDLMDACIVSI---EQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGEC 457
               :.|||....|:|.   ...:..|. ..|.|.|..|:..:||..:::.|.       :.:|
  Rat   937 ---SPSDLNKRFILSFLHAHGKLFTRI-GMETFPAVAEKVLKEFQVLLQHSP-------SPIG-- 988

  Fly   458 ERKDKKLMP------RPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDL 516
            ..:..:||.      ....||||.|         ||.::........:|.|:.         |.|
  Rat   989 STRMLQLMTINMFAVHNSQLKDCFS---------EECRSVIQEQAASLGLAMF---------SLL 1035

  Fly   517 KTPLSCKSKRRGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAA 581
            ....:|..|                |.:....|..|       |:||..|:
  Rat  1036 VQRCTCLLK----------------DSAKAQLSSPE-------DQEDQDDI-------------- 1063

  Fly   582 DPGEPCGEERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEAD 646
                                                                     :.:|...|
  Rat  1064 ---------------------------------------------------------KVSSFVPD 1071

  Fly   647 SEELLRSFEVLQLNFKSAEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINPNIVIDCLHNEPTIR 711
            .:|||.|.:|.........|..:    |||.|...|.:              :.:|.
  Rat  1072 LKELLPSVKVWSDWMLGYPDTWN----PPPTSLDLPLQ--------------VAVDV-------- 1110

  Fly   712 ALKMLFDWLRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVEL 776
                   |                      ..|.::|||             ||..|
  Rat  1111 -------W----------------------STLADFCNI-------------LTAVN-------- 1125

  Fly   777 FDVRANVPLTEDFAFKNFDIFQSTQITLDWETIIRERV----TPQEESIL-------------RI 824
               ::.|||.:|   .:.|:   |.:.|:.:.::...|    .||:...:             |:
  Rat  1126 ---QSEVPLYKD---PDDDL---TLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRV 1181

  Fly   825 FKMVDFGFFICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRT 889
            ..:..|...:|.|::....|                   |||    :....||..:.
  Rat  1182 TVLKYFLEALCGQEEPLLAF-------------------KGG----KYVSVAPVPDT-------- 1215

  Fly   890 RRYSDRKNGIVRKSYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATGTSVAGGTSASTT 954
               ..::.||.......:||:|.|.|       .:..:..||
  Rat  1216 ---MGKEMGIQEGKQLEDEEEDVVIE-------DFEEDSEAE----------------------- 1247

  Fly   955 TNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVE-----TLEEELRDSPAHVVMSP-F 1013
                        .||.:::..|.::||..|..|:..|...:     .||::.:.....:.:.| |
  Rat  1248 ------------GSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLF 1300

  Fly  1014 VVVDSKALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKR--------------SENVRHVIR 1064
            :|.|:....::...:..|:.::|.|:::|..|:||||.|.|.              .|..|..|.
  Rat  1301 LVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIE 1365

  Fly  1065 WLEQEFKQGNRHLRA--QRDNESQPLSLLK--ISRKMDRDASVFLQIAQFCNHLVANHADPHVS- 1124
            :||:.|:..:..|||  .|.||.:.::...  |:.::..:..:.|..   |.|...:.|..::.
  Rat  1366 FLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSC---CLHYCKDKAKDYMPT 1427

  Fly  1125 ------ELQKSVVTYLSGDNLHEKNRQQQNFSYTGILDSIPVR-------YAQI 1165
                  .|.:.||......||..|          .:..::|||       :||:
  Rat  1428 SKEEPIRLLREVVLLTDDRNLRVK----------ALTRNVPVRDIPAFLTWAQV 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	21/125 (17%)
		EST1_DNA_bind	240..478	CDD:287359	55/268 (21%)
		PIN_Smg5	1012..1173	CDD:189054	43/187 (23%)
Smg6	NP_001099278.1	EST1	691..794	CDD:287360	24/132 (18%)
		EST1_DNA_bind	804..1156	CDD:287359	100/607 (16%)
		TPR repeat	818..848	CDD:276809	11/29 (38%)
		TPR repeat	853..876	CDD:276809	5/22 (23%)
		PIN_Smg6	1294..1469	CDD:189055	41/187 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900