DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and est1

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_596232.1	Gene:	est1 / 2540492	PomBaseID:	SPBC2D10.13	Length:	490	Species:	Schizosaccharomyces pombe

Alignment Length:	454	Identity:	93/454 - (20%)
Similarity:	176/454 - (38%)	Gaps:	127/454 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FQHEIEEK-RSLLVQLCKQII--FKDYQSVGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQ 131
            |:|::.|| .::.:::.|:::  .|..|:...:..:::|...:|:.|...:..:.:........:
pombe    29 FKHDLYEKIIAIEIEVEKKLLNRLKSIQTNTFERPDIIWSCCHYKIIQHFRSRFREIHPRHVVEK 93

  Fly   132 ENMQKL-ERFL--CAGIFNYKRLSARMEEIYDLDLKYLIDF------SIISDGYISDMIGDTMES 187
            :..:|: .:||  || || |:...:.:...:.|| .|...|      :.:|....:|.:....|:
pombe    94 KKTKKVFFKFLKTCA-IF-YQTCISELISKFQLD-SYRPFFCKWTSSATVSSTISNDEMSSIPEA 155

  Fly   188 SHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISK----EQVAKYYLEAFK 248
            |:|..|     :|    ||:.:::..:.|||:.||       |...:.|    ::...:|..|.:
pombe   156 SYSRNH-----ME----ALECVYNCFIYLGDMARY-------SSTCLKKRGAYDRALGFYDLAHR 204

  Fly   249 LNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNL--------NKLFAKHTEY- 304
            ..|..||.:||:..:.......::|.|.:..:|....|.:.:..||        .:.||.|.|:
pombe   205 TLPGNGMHRNQIAVVWASDECIVESIYWFSSALCSEDPPKSALLNLLKQLIAFYRRCFAVHFEFV 269

  Fly   305 -----------------LERMDPEK-------------LDFNIEDFFARFYLIVDIFFFDKEVPD 339
                             |:.:.|.|             |..||.:.   .|...::::....
pombe   270 SPMMILLFIISDCCIHSLKEIQPFKCPSIMVKDLENSLLQSNIRNV---GYEKKNLYYISSA--- 328

  Fly   340 FNALCHCVLIDLRKILCSQQLRVPEPSIFKIVSILFF----CLSKLKMINSPKVYSLHAFLVAAC 400
            |:.|.||     |...|:.:||   ...::..|.||.    |..:::...:|..|
pombe   329 FSNLLHC-----RYFNCNDRLR---SFYYRFSSWLFHQTLACAKEVESERAPTSY---------- 375

  Fly   401 SDLMDACIVSIEQTILARA----------QDNERFQAEY-----EERFQEFDTVVRKSRNEYKN 449
               :.:|:.|| :.||||.          :.||..|..|     |:.|:|      .|.|:..|
pombe   376 ---LTSCLPSI-KVILARVLESSPAFGFIERNELEQLSYHFRICEKFFKE------SSENKMLN 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	27/131 (21%)
		EST1_DNA_bind	240..478	CDD:287359	55/268 (21%)
		PIN_Smg5	1012..1173	CDD:189054
est1	NP_596232.1	EST1	64..184	CDD:287360	30/138 (22%)
est1	NP_596232.1	EST1_DNA_bind	195..450	CDD:287359	55/269 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15696
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000