DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and SMG6

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_060045.4	Gene:	SMG6 / 23293	HGNCID:	17809	Length:	1419	Species:	Homo sapiens

Alignment Length:	1221	Identity:	214/1221 - (17%)
Similarity:	380/1221 - (31%)	Gaps:	479/1221 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KDLYRSLYTASKQLDDAKRNVQSVGQLFQHEIE---EKRSLLVQLCKQIIFKDYQ-SVGKKVREV 103
            ::|:|.|..|..| :....|:.|..::....:|   :.|:.|:||.::.|..|.: |..:.|.::
Human   579 QELHRLLRVADNQ-ELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQI 642

  Fly   104 MWRRGYYEFIAFVKKNWHKQCQD--AATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYL 166
            :|:..:|:.|    :.:.:..:|  ....::...:|...|..|...:..|..:::..|...|:..
Human   643 LWKNAFYQVI----EKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDY 703

  Fly   167 IDFSIISDGYISDMIGDTMESSHSGTHAVDKSL-EAVSFALDTIHSSLLSLGDLHRYFLDFRIDS 230
            :|                      |.....|.| :.|.:||.:....::..||:.||    |..:
Human   704 MD----------------------GLAIRSKPLRKTVKYALISAQRCMICQGDIARY----REQA 742

  Fly   231 KLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLN 295
            ..:.:..:...:||:|..:.|..|...|||..|.......||:.|:|:.||....|...::.:|.
Human   743 SDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLM 807

  Fly   296 KLF---AKHTEYLERMDPEKLDFNIEDFFARFYLIVDIFFFDKEVPDFNALCHCVLIDLRKILCS 357
            .||   .:..|.:|:...|:.|.:                     ||
Human   808 SLFEETKRKAEQMEKKQHEEFDLS---------------------PD------------------ 833

  Fly   358 QQLRVPEPSIFKIVSILFFCLSKLKMINSPK-------------------VYSLHAFLVAACSDL 403
             |.|..:.|.|:.|.   ...::|::...|.                   :.||      :.|||
Human   834 -QWRKGKKSTFRHVG---DDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSL------SPSDL 888

  Fly   404 MDACIVSI---EQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGECERKDKKLM 465
            ....|:|.   ...:..|. ..|.|.|..|:..:||..:::.|.       :.:|  ..:..:||
Human   889 NKRFILSFLHAHGKLFTRI-GMETFPAVAEKVLKEFQVLLQHSP-------SPIG--STRMLQLM 943

  Fly   466 P------RPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKS 524
            .      ....||||.|         ||.::........:|.|:.:
Human   944 TINMFAVHNSQLKDCFS---------EECRSVIQEQAAALGLAMFS------------------- 980

  Fly   525 KRRGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGE 589
                :.:||          .:|...||.           ...|||..|.|
Human   981 ----LLVRR----------CTCLLKESA-----------KAQLSSPEDQD--------------- 1005

  Fly   590 ERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSF 654
                                         |.:|:.:               :|...|.:|||.|.
Human  1006 -----------------------------DQDDIKV---------------SSFVPDLKELLPSV 1026

  Fly   655 EVLQLNFKSAEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINPNIVIDCLHNEPTIRALKMLFDW 719
            :|.........|..:    |||.|...|              .::.:|.               |
Human  1027 KVWSDWMLGYPDTWN----PPPTSLDLP--------------SHVAVDV---------------W 1058

  Fly   720 LRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVELFDVRANVP 784
                                  ..|.::|||             ||..|           ::.||
Human  1059 ----------------------STLADFCNI-------------LTAVN-----------QSEVP 1077

  Fly   785 LTEDFAFKNFDIFQSTQITLDWETIIRERV----TPQEESIL-------------RIFKMVDFGF 832
            |.:|   .:.|:   |.:.|:.:.::...|    .||:...:             |:..:..|..
Human  1078 LYKD---PDDDL---TLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLE 1136

  Fly   833 FICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRTR--RYSDR 895
            .:|.|::....|                   |||    :....||..:...:..|...  |..|.
Human  1137 ALCGQEEPLLAF-------------------KGG----KYVSVAPVPDTMGKEMGSQEGTRLEDE 1178

  Fly   896 KNGIVRKSYTSNEE------KDTVEECR----KMPRKGYLRNRNAEKAAAVITSATGTSVAGGTS 950
            :..:|.:.:..:.|      :|.:.|.|    .:.||...:.|..||..||:
Human  1179 EEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVL------------- 1230

  Fly   951 ASTTTNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSPFVV 1015
                                 |:.|:.:.                 :|.|:|..        |:|
Human  1231 ---------------------EDHSQMRQ-----------------MELEIRPL--------FLV 1249

  Fly  1016 VDSKALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKR--------------SENVRHVIRWL 1066
            .|:....::...:..|:.::|.|:::|..|:||||.|.|.              .|..|..|.:|
Human  1250 PDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFL 1314

  Fly  1067 EQEFKQGNRHLRA--QRDNESQPLSLLK--ISRKMDRDASVFLQIA-QFC-----NHLVANHADP 1121
            ||.|:..:..|||  .|.||.:.::...  |:.::..:..:.|... .:|     :.:.|:..:|
Human  1315 EQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEP 1379

  Fly  1122 HVSELQKSVVTYLSGDNLHEKNRQQQNFSYTGILDSIPVR-------YAQI 1165
              ..|.:.||......||..|          .:..::|||       :||:
Human  1380 --IRLLREVVLLTDDRNLRVK----------ALTRNVPVRDIPAFLTWAQV 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	20/125 (16%)
		EST1_DNA_bind	240..478	CDD:287359	55/268 (21%)
		PIN_Smg5	1012..1173	CDD:189054	43/185 (23%)
SMG6	NP_060045.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..79
		EJC-binding motif 1, mediates interaction with the EJC	39..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..165
		Interaction with telomeric DNA	114..503
		EJC-binding motif 2, mediates interaction with the EJC	133..153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..405
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..472
		EST1	638..741	CDD:287360	23/132 (17%)
		EST1_DNA_bind	751..1103	CDD:287359	101/607 (17%)
		TPR repeat	765..795	CDD:276809	11/29 (38%)
		TPR repeat	800..823	CDD:276809	5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..883		1/28 (4%)
		PIN_Smg6	1241..1416	CDD:189055	43/194 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810