Protein Alignment Smg5 and Smg5

DIOPT Version :10

• Sequence 1: NP_609685.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Sequence 2: NP_839977.2
• Gene: Smg5 / 229512
• MGIID: 2447364
• Length: 1017
• Species: Mus musculus
• Alignment Length: 1231
• Identity: 268/1231 - (21%)
• Similarity: 439/1231 - (35%)
• Gaps: 406/1231 - (32%)

  Fly    43 KDLYRSLYTASKQLDDAKRNVQSVGQLFQHEIEEKRSLLVQLCKQIIFKDYQSVGKKVREVMWRR 107
            |.|||::..|..:||....|..:..::|:.|....|:.|.:||.:::|......|:|..|::||:
Mouse    21 KRLYRAVVEAVHRLDLILCNKAAYQEVFKPENVSLRNKLRELCVKLMFLHPVDYGRKAEELLWRK 85

  Fly   108 GYYEFIAFVKKNWHKQCQDAATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSII 172
            .|||.|..:|.| .|.....:|.:   ......|.|||..|:.|...::..|.|:|:..||::.:
Mouse    86 VYYEVIQLIKTN-KKHIHSRSTLE---CAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHV 146

  Fly   173 SDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFR-IDSKLSISK 236
            :|    .::|.....|.||        :.:.:|....|..|:.||||.||..:.. :|::|
Mouse   147 TD----PLMGFKKPVSASG--------KEMDWAQMACHRCLVYLGDLSRYQNELAGVDTEL---- 195

  Fly   237 EQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLF--- 298
             ...::|.:|..:.|.|||..||||||...:.:::::.|.||..:...:.||.:..||.:|:
Mouse   196 -LAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA 259

  Fly   299 AKHTEYLERMDPEKLD------FNIEDFFARFYLIVDIF-----FFDKEVPDFNALCHCVLIDLR 352
            ||....|::.:..||.      .:|:.....|..:..:.     ..|.|:   .:||..||.|..
Mouse   260 AKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSEL---TSLCQSVLEDFN 321

  Fly   353 KILC---------------------SQQLRVPEPSIFKIVSILFFCLSKLKMINSPKVYSLHAFL 396
              ||                     |....:|:..||::..|....:..||...|....:..||.
Mouse   322 --LCLFYLPSSPNLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKHYSAAIAFT 384

  Fly   397 VAACSDLMDACIVSIEQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGECERKD 461
            :|..|.|::              ..|.|.|||.||                       ||
Mouse   385 LALFSHLIN--------------HVNIRLQAELEE-----------------------GE----- 407

  Fly   462 KKLMPRPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKSKR 526
                   :.:....||..|...| :||..:|..:.:   .......:||.::|...:.|||
Mouse   408 -------NPVSAFQSDGTDEPES-KEALEKEEPEPE---PPTVVPQADEGRKSRKHSRLSC---- 457

  Fly   527 RGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGEER 591
              :|.|||.......|||                     |||..|::| |..|:|
Mouse   458 --LRRRRRHHPPKAGDDS---------------------DLSEGFESD-SSHDSA---------- 488

  Fly   592 YAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSFEV 656
                       :|..|...|         .|..:|.....:..|.:...||||:.|:
Mouse   489 -----------QASDGSDSG---------SDKSLEGRGTAFDAETDSEMNSQESRSD-------- 525

  Fly   657 LQLNFKSAEDAQSKPVAPPPVSFSEPPKKL---------------------VYRNK--------Y 692
              |.....|:....|...||.:.||.|..|                     :::.|        :
Mouse   526 --LEDMEDEEGTRSPAQEPPQARSEVPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTF 588

  Fly   693 TKI------NPNIV--------------------------------------------IDCLHNE 707
            :.:      .||.|                                            :..|..|
Mouse   589 SNLLLQPTTEPNSVASHRPCVNGDMDKPLEPASEDGSESEGSESSNRSCRNERSLQEKLQALMAE 653

  Fly   708 PTIRALKMLFDWLRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDS 772
            ..:.|:|:..||||.||:::|.|..|:....:::..|||.               |..:|.::||
Mouse   654 GLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNL---------------LPASAELQDS 703

  Fly   773 LV-------------ELFDVRANVPLTEDFAFKNFDIFQSTQITLDWETIIRERVTPQEESILRI 824
            .:             ||.|:.|::.|.||.|.:|....::.....:::. .|..::..|||::||
Mouse   704 GLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDA-DRPLLSALEESVVRI 767

  Fly   825 FKMVDFGFFICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRT 889
            ..:..||.|:.:
Mouse   768 CCIRSFGHFVAR----------------------------------------------------- 779

  Fly   890 RRYSDRKNGIVRKSYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATGTSVAGGTSASTT 954
                                           .:|.:...|.|....|            :.|.:.
Mouse   780 -------------------------------LQGSILQFNPEVGIFV------------SIAQSE 801

  Fly   955 TNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSPFVVVDSK 1019
            ..|::::...|.....:|.|   :::....|.:|.||.||..||..|:...|...|||:::.|::
Mouse   802 QESLLQQAQAQFRMAEEEAR---RNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLIPDTQ 863

  Fly  1020 ALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKRSENVRHVIRWLEQEFKQGNRHLRAQRD-N 1083
            ||..:..:::.|..:.:.|::||..|::.||.|||.....|..||:||.|||:|||::|.|:: .
Mouse   864 ALCYHLPLIRQLATSGRFIIIIPRTVIDGLDLLKKEQPGARDGIRYLEAEFKKGNRYIRCQKEVG 928

  Fly  1084 ESQPLSLLKISRKMDRDASVFLQIAQFCNHLV----ANHADPHVSELQKSVVTYLSGDNLH 1140
            :|.....||   :.|.||....:|...|..|.    |...||      ..:||.::|  ||
Mouse   929 KSFERHKLK---RQDADAWTLYKILDSCRQLTLAQGAGEEDP------SGMVTIITG--LH 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_609685.1	EST1	99..227	CDD:463062	37/127 (29%)
		EST1_DNA_bind	240..479	CDD:431239	60/273 (22%)
		MSCRAMM_ClfA	<470..>580	CDD:468110	26/109 (24%)
		PIN_Smg5-like	1012..1173	CDD:350232	44/134 (33%)
Smg5	NP_839977.2	EST1	77..188	CDD:463062	29/110 (26%)
		EST1_DNA_bind	197..>411	CDD:431239	61/249 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..562		33/155 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..640		9/42 (21%)
		EST1_DNA_bind	<652..745	CDD:431239	27/171 (16%)
		PIN_Smg5-like	856..1014	CDD:350232	26/157 (17%)