DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smg5 and Smg5

DIOPT Version :9

Sequence 1:NP_001285914.1 Gene:Smg5 / 34804 FlyBaseID:FBgn0019890 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_839977.2 Gene:Smg5 / 229512 MGIID:2447364 Length:1017 Species:Mus musculus


Alignment Length:1231 Identity:268/1231 - (21%)
Similarity:439/1231 - (35%) Gaps:406/1231 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 KDLYRSLYTASKQLDDAKRNVQSVGQLFQHEIEEKRSLLVQLCKQIIFKDYQSVGKKVREVMWRR 107
            |.|||::..|..:||....|..:..::|:.|....|:.|.:||.:::|......|:|..|::||:
Mouse    21 KRLYRAVVEAVHRLDLILCNKAAYQEVFKPENVSLRNKLRELCVKLMFLHPVDYGRKAEELLWRK 85

  Fly   108 GYYEFIAFVKKNWHKQCQDAATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSII 172
            .|||.|..:|.| .|.....:|.:   ......|.|||..|:.|...::..|.|:|:..||::.:
Mouse    86 VYYEVIQLIKTN-KKHIHSRSTLE---CAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHV 146

  Fly   173 SDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFR-IDSKLSISK 236
            :|    .::|.....|.||        :.:.:|....|..|:.||||.||..:.. :|::|    
Mouse   147 TD----PLMGFKKPVSASG--------KEMDWAQMACHRCLVYLGDLSRYQNELAGVDTEL---- 195

  Fly   237 EQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLF--- 298
             ...::|.:|..:.|.|||..||||||...:.:::::.|.||..:...:.||.:..||.:|:   
Mouse   196 -LAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA 259

  Fly   299 AKHTEYLERMDPEKLD------FNIEDFFARFYLIVDIF-----FFDKEVPDFNALCHCVLIDLR 352
            ||....|::.:..||.      .:|:.....|..:..:.     ..|.|:   .:||..||.|..
Mouse   260 AKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSEL---TSLCQSVLEDFN 321

  Fly   353 KILC---------------------SQQLRVPEPSIFKIVSILFFCLSKLKMINSPKVYSLHAFL 396
              ||                     |....:|:..||::..|....:..||...|....:..||.
Mouse   322 --LCLFYLPSSPNLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKHYSAAIAFT 384

  Fly   397 VAACSDLMDACIVSIEQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGECERKD 461
            :|..|.|::              ..|.|.|||.||                       ||     
Mouse   385 LALFSHLIN--------------HVNIRLQAELEE-----------------------GE----- 407

  Fly   462 KKLMPRPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKSKR 526
                   :.:....||..|...| :||..:|..:.:   .......:||.::|...:.|||    
Mouse   408 -------NPVSAFQSDGTDEPES-KEALEKEEPEPE---PPTVVPQADEGRKSRKHSRLSC---- 457

  Fly   527 RGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGEER 591
              :|.|||.......|||                     |||..|::| |..|:|          
Mouse   458 --LRRRRRHHPPKAGDDS---------------------DLSEGFESD-SSHDSA---------- 488

  Fly   592 YAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSFEV 656
                       :|..|...|         .|..:|.....:..|.:...||||:.|:        
Mouse   489 -----------QASDGSDSG---------SDKSLEGRGTAFDAETDSEMNSQESRSD-------- 525

  Fly   657 LQLNFKSAEDAQSKPVAPPPVSFSEPPKKL---------------------VYRNK--------Y 692
              |.....|:....|...||.:.||.|..|                     :::.|        :
Mouse   526 --LEDMEDEEGTRSPAQEPPQARSEVPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTF 588

  Fly   693 TKI------NPNIV--------------------------------------------IDCLHNE 707
            :.:      .||.|                                            :..|..|
Mouse   589 SNLLLQPTTEPNSVASHRPCVNGDMDKPLEPASEDGSESEGSESSNRSCRNERSLQEKLQALMAE 653

  Fly   708 PTIRALKMLFDWLRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDS 772
            ..:.|:|:..||||.||:::|.|..|:....:::..|||.               |..:|.::||
Mouse   654 GLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNL---------------LPASAELQDS 703

  Fly   773 LV-------------ELFDVRANVPLTEDFAFKNFDIFQSTQITLDWETIIRERVTPQEESILRI 824
            .:             ||.|:.|::.|.||.|.:|....::.....:::. .|..::..|||::||
Mouse   704 GLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDA-DRPLLSALEESVVRI 767

  Fly   825 FKMVDFGFFICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRT 889
            ..:..||.|:.:                                                     
Mouse   768 CCIRSFGHFVAR----------------------------------------------------- 779

  Fly   890 RRYSDRKNGIVRKSYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATGTSVAGGTSASTT 954
                                           .:|.:...|.|....|            :.|.:.
Mouse   780 -------------------------------LQGSILQFNPEVGIFV------------SIAQSE 801

  Fly   955 TNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSPFVVVDSK 1019
            ..|::::...|.....:|.|   :::....|.:|.||.||..||..|:...|...|||:::.|::
Mouse   802 QESLLQQAQAQFRMAEEEAR---RNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLIPDTQ 863

  Fly  1020 ALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKRSENVRHVIRWLEQEFKQGNRHLRAQRD-N 1083
            ||..:..:::.|..:.:.|::||..|::.||.|||.....|..||:||.|||:|||::|.|:: .
Mouse   864 ALCYHLPLIRQLATSGRFIIIIPRTVIDGLDLLKKEQPGARDGIRYLEAEFKKGNRYIRCQKEVG 928

  Fly  1084 ESQPLSLLKISRKMDRDASVFLQIAQFCNHLV----ANHADPHVSELQKSVVTYLSGDNLH 1140
            :|.....||   :.|.||....:|...|..|.    |...||      ..:||.::|  ||
Mouse   929 KSFERHKLK---RQDADAWTLYKILDSCRQLTLAQGAGEEDP------SGMVTIITG--LH 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smg5NP_001285914.1 EST1 99..222 CDD:287360 35/122 (29%)
EST1_DNA_bind 240..478 CDD:287359 59/272 (22%)
PIN_Smg5 1012..1173 CDD:189054 44/134 (33%)
Smg5NP_839977.2 EST1 77..187 CDD:287360 29/109 (27%)
TPR repeat 172..206 CDD:276809 9/34 (26%)
EST1_DNA_bind 197..>411 CDD:287359 61/249 (24%)
TPR repeat 211..241 CDD:276809 10/29 (34%)
TPR repeat 246..268 CDD:276809 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..562 33/155 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..640 9/42 (21%)
PIN_SF 856..1014 CDD:301351 26/157 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850665
Domainoid 1 1.000 46 1.000 Domainoid score I12065
eggNOG 1 0.900 - - E1_KOG2162
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 129 1.000 Inparanoid score I4633
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45620
OrthoDB 1 1.010 - - D102776at33208
OrthoFinder 1 1.000 - - FOG0008183
OrthoInspector 1 1.000 - - oto94238
orthoMCL 1 0.900 - - OOG6_107519
Panther 1 1.100 - - LDO PTHR15696
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5305
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.800

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