DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and Smg7

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_006529513.1	Gene:	Smg7 / 226517	MGIID:	2682334	Length:	1192	Species:	Mus musculus

Alignment Length:	698	Identity:	133/698 - (19%)
Similarity:	224/698 - (32%)	Gaps:	243/698 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EIEEKRSLLVQLCKQIIFKDYQ-SVGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQENMQK 136
            |:...|..|..|.::::..|.: ::.|||.:.:|...:        ||.....|..|..:.|..:
Mouse    36 EVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAF--------KNQITTLQGQAKNRANPNR 92

  Fly   137 ------LERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSIISDGYISDMIGDTMESSHSGTHAV 195
                  |..||.|....|.:|...:..::::||...:..|.:  |.||:      :.:||.| .|
Mouse    93 SEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQL--GIISN------KQTHSST-IV 148

  Fly   196 DKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQL 260
            .....:.|:   .....|:.|||:.||          .....|...||..|.:|.|:.|...|||
Mouse   149 KPQSSSCSY---ICQHCLVHLGDIARY----------RNQTSQAESYYRHAAQLVPSNGQPYNQL 200

  Fly   261 GTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLFAKHTEYLERMDPEKLDFNIEDFFARFY 325
            ..|...:...|.:.::|..|:....||..:..||.|..:|   .||..|..|..:.:.||...|.
Mouse   201 AILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSK---ALESRDELKTKWGVSDFIKAFI 262

  Fly   326 LIVDIFFFDKEVPDFNALCHCVLIDLRKILCSQQLRVPEPSIFKIVSILFFCLSKLKMINSPKVY 390
            ......:..|.:..        |..||:.|..|         ||  .:||     .|..||
Mouse   263 KFHGHVYLSKSLEK--------LSPLREKLEEQ---------FK--RLLF-----QKAFNS---- 299

  Fly   391 SLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEE-----------RFQEFDTVV---- 440
                      ..|:...::::.|....|...||..|..|.:           .|..|..::
Mouse   300 ----------QQLVHVTVINLFQLHHLRDFSNETEQHSYSQDEQLCWTQLLALFMSFLGILCKCP 354

  Fly   441 -----RKSRNEY--------KNWLAAVGECERKDKKLMPRPHSLKDCSSDSR-----------DS 481
                 ::|.|.|        .:||..             ||...::...|.|           :|
Mouse   355 LQNDSQESNNAYPLPAVKVSMDWLRL-------------RPRVFQEAVVDERQYIWPWLISLLNS 406

  Fly   482 QHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKSKRRGM----------------- 529
            .|..|:             :..:|.::...:|.:|:..|:.:...|.:
Mouse   407 FHPRED-------------DLSNTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQ 458

  Fly   530 -RLRRRR-----RKIAQSDDS--SCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEP 586
             |:|::|     :.||.:...  .|.:...:|                .|.|:..::...||.|.
Mouse   459 RRIRQQRLISIGKWIADNQPRLIQCENEVGKL----------------LFITEIPELILEDPSEA 507

  Fly   587 CGEERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELL 651
                                             .|:::::|..:|         .|...|....|
Mouse   508 ---------------------------------KENLILQETSVV---------ESLATDGSPGL 530

  Fly   652 RSFEVLQLNFKSAEDAQSKPVAPPPVSFSE-------------PPKKL 686
            :|......|..::.|:..|||    |:|.|             |||::
Mouse   531 KSVLSTGRNPSNSCDSGEKPV----VTFKENIKPREVNQGRSFPPKEV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	29/128 (23%)
		EST1_DNA_bind	240..478	CDD:287359	55/265 (21%)
		PIN_Smg5	1012..1173	CDD:189054
Smg7	XP_006529513.1	EST1	63..175	CDD:371012	31/141 (22%)
		TPR repeat	162..188	CDD:276809	10/35 (29%)
		EST1_DNA_bind	179..438	CDD:371011	64/325 (20%)
		TPR repeat	193..223	CDD:276809	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900