Protein Alignment Smg5 and smg-6

DIOPT Version :9

• Sequence 1: NP_001285914.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Sequence 2: NP_497566.3
• Gene: smg-6 / 175367
• WormBaseID: WBGene00004884
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1190
• Identity: 201/1190 - (16%)
• Similarity: 344/1190 - (28%)
• Gaps: 465/1190 - (39%)

  Fly    11 SNASSECAIDGGTNRCR--GLEPNNGTCILSQEVKDLYRSLYTASKQLDDAKRNVQSVGQLFQHE 73
            |...||.|.....||.|  .::.|.|..|  :|:.:....|....|     ||:::|..::.:..
 Worm   461 SQNQSEMANRAEINRRRQEDIDRNEGKQI--REISEKIEKLSAPVK-----KRDLKSAEKMAEIS 518

  Fly    74 IEEKRSLLVQLCKQIIFKD-YQSVGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQENMQKL 137
            :|     |..:..|:|..| ..|....:.:.::|:.:|:.|..::...:....||...:...|||
 Worm   519 ME-----LANIYSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGSNSAAPDARLIRAVTQKL 578

  Fly   138 ERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSI-------ISDGYISDMIGDTMESSHSGTHAV 195
               |..||..|:.|.|..|..:.:.|...:.:..       :.:.||...||  ::...|.|...
 Worm   579 ---LLNGIVYYENLIATYETQFHVALTDALTWQSGSPSDEELCEQYIELPIG--IQKFDSATQKT 638

  Fly   196 DKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQL 260
                     |:.::...|:||||||||...........|||    ..|.::.:|.|:.|...|||
 Worm   639 ---------AIKSLSRHLISLGDLHRYKSLIDGSENYEISK----SCYQKSSQLWPSTGHPYNQL 690

  Fly   261 GTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLFAKHTEYLERMDPEKLDFNIEDFFARFY 325
            |.:.|         |..||.                                        .||..
 Worm   691 GIVVY---------YSMLYR----------------------------------------SARRA 706

  Fly   326 LIVDIFFFDKEVPDFNALCHCVLIDLRKILCSQQLRVPEPSIFKIVSILFFCLSKLKMINSPKVY 390
            .:|.:....::                     :|.||.:.         ||||::
 Worm   707 RLVPVDVLSRQ---------------------RQKRVIDE---------FFCLTR---------- 731

  Fly   391 SLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEER---FQEFDTVVRKSRNEYKNWLA 452
                  ..|||...:.....::|.|.|......::|...::.   .:|...|:|:.:...:.|:
 Worm   732 ------ALACSHPYEVAKDRLKQRIDAMRTKVAKYQPVLDKESGIVKEQGNVLRRLQRIRQIWI- 789

  Fly   453 AVGECERKDKKLMPRPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLK 517
                            |.:.:.|.|                ..|::|.:.|.....:.:|....:
 Worm   790 ----------------HPITETSQD----------------GTGERIVDDVLVHFMEHSKAKLHR 822

  Fly   518 TPLSCKSKRRGMRLRR----RRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDI 578
            ..:|......||.:.:    ....:::......|.|.|:.:|||.:|:  ....|:.|
 Worm   823 RAVSYLCDTFGMLVTKIGMDHFESVSERAFGLLYASLSKSETDFSADQ--LVKFSAMF------- 878

  Fly   579 DAADPGEPCGEERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQ 643
                        .|||
 Worm   879 ------------IYAA------------------------------------------------- 882

  Fly   644 EADSEELLRSFEVLQLNFKSAEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINPNIVIDCLHNEP 708
                          |:||..:..:.||......|           |..:|.....:.....|...
 Worm   883 --------------QVNFDKSTPSTSKSQLHTAV-----------RTIFTYFLVLLEHISTHTTL 922

  Fly   709 TIRALKMLFDWLRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSL 773
            .:.|..::..|:          .|::.|      :||:|..        :.|
 Worm   923 LLPAANVIATWI----------LHADTE------ELLSYLE--------HLE------------- 950

  Fly   774 VELFDVRANVPLTEDF--AFKNFDIFQSTQITLDWETIIRERVTPQEESILRIFKMVDFGFFICK 836
                      ||:...  :|.||      ...|:.|....|.||..|..:|.       .||
 Worm   951 ----------PLSSTIISSFSNF------PPNLESEAENPENVTTPEAILLA-------SFF--- 989

  Fly   837 QKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRTRRYSDRKNGIVR 901
                                                                             
 Worm   990 ----------------------------------------------------------------- 989

  Fly   902 KSYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATGTSVAGGTSASTTTNSVIEKLNLQS 966
            |.|   |...|...|                                 |.||..:..:|||.:..
 Worm   990 KIY---EPNPTPVRC---------------------------------SRSTNISQAVEKLKILG 1018

  Fly   967 SSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSP-FVVVDSKALTEYNGIVKS 1030
            .|....|:|....|:....|....::..:.::|:.......:|:.| :::.|:..|.....::|:
 Worm  1019 FSAEKSEKSGENGKQKLGDGLEEPKSREQMIDEQRGLGKTTIVIHPEYLIPDTNVLIGDLQLMKN 1083

  Fly  1031 LVRT----KKCIVLIPNAVLNELD--------DLKKRSE--------NVRHVIRWLEQEFKQGNR 1075
            |:.|    ||..:|:|..||:||.        |.|..||        ..:..:.||:::.||...
 Worm  1084 LLETAQKNKKFQILVPTTVLDELQYIAKLSPLDSKSNSEAHDPERISKAKIAVAWLKEQAKQKTG 1148

  Fly  1076 HLRAQRDNESQPLSLLKIS-----RKMDRDASVFLQIAQFCNHLVANHADPHVSEL-QKSVVTYL 1134
            ||........:..:|..:|     .:|..:..:.|..|...:..:.....|..:|: ||.|:  :
 Worm  1149 HLYTLTTTGKRLPTLSIVSEDLEGHEMTTNDDMILNSALRWSESLPGSTAPSATEISQKCVL--I 1211

  Fly  1135 SGDNLHEKNRQQQNFSYTGI 1154
            :||..........||...||
 Worm  1212 TGDRGLTIKAIGNNFPCRGI 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	30/129 (23%)
		EST1_DNA_bind	240..478	CDD:287359	35/240 (15%)
		PIN_Smg5	1012..1173	CDD:189054	40/170 (24%)
smg-6	NP_497566.3	EST1	541..661	CDD:371012	32/133 (24%)
		EST1_DNA_bind	669..995	CDD:371011	91/683 (13%)
		PIN_Smg6-like	1060..1237	CDD:350233	41/174 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I3728
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050