DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg5 and smg6

DIOPT Version :9

Sequence 1:	NP_001285914.1	Gene:	Smg5 / 34804	FlyBaseID:	FBgn0019890	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_005172798.4	Gene:	smg6 / 100334020	ZFINID:	ZDB-GENE-081107-52	Length:	1544	Species:	Danio rerio

Alignment Length:	933	Identity:	170/933 - (18%)
Similarity:	294/933 - (31%)	Gaps:	312/933 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 NVQSVGQLFQHEIE---EKRSLLVQLCKQIIFKDYQ-SVGKKVREVMWRRGYYEFIAFVKKNWHK 122
            |:.|..:|.|..:|   :.|:.|:.:.:::|..|.: |..:.|.:.:|:..:|:.|...::....
Zfish   714 NLLSRERLSQEGLERMAQLRAELLTIYERVILTDIEFSDSQNVDQTLWKNVFYQVIERFRQLLKD 778

  Fly   123 QCQDAATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSIISDGYISDMIGDTMES 187
            |..|.|...:.|  |...|..|...:..|..:::.::...|:                  |.|:.
Zfish   779 QNSDTAPQIKTM--LMTILEEGAVFFDSLLQKLQSVFQFKLQ------------------DYMDC 823

  Fly   188 SHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKEQVAKYYLEAFKLNPA 252
            .......:.|:   |.:||.:....::..||:.||    |..:..|.:..:...:||:|.::.|.
Zfish   824 MAIRARPLRKT---VKYALISAQRCMICQGDIARY----REQASESANYGKARSWYLKAQQIAPK 881

  Fly   253 IGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLF---AKHTEYLER------- 307
            .|...|||..|.......||:.|:|:.||....|...::.:|..||   .:..:.:||
Zfish   882 NGRPYNQLALLAVYTKRKLDAVYYYMRSLAASNPILTAKESLMSLFEEAKRKADQVERRLKQDSD 946

  Fly   308 ----------------------------------------------MDPEKLDFNIEDFFARFYL 326
                                                          .|.|....:..|...||.|
Zfish   947 GSAHGPKGHTGGRRGEDAARVEIWIRPSEVSGTSRPTGSESGKDSEQDGELGALSASDLNKRFIL 1011

  Fly   327 IV----DIFFFDKEVPDFNALCHCVLIDLRKILCSQQLRVPEPSIFKIVSILFFCL--SKLKMIN 385
            ..    ...|....:..|.|:.:.||::.|.:|......:....:.:|::|..|.:  ::::...
Zfish  1012 SFLHAHGKLFTKVGMESFPAVANRVLLEFRALLQHSPSPLGSTRMLQIITINMFTIYNAQIRAKG 1076

  Fly   386 SPKVYS------------LHAFLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEERFQEFDT 438
            ..:..|            :...||..|::|:             :....|...||....|.|.|.
Zfish  1077 QGETRSALEEQAISLGLAMFGLLVQRCTELL-------------KETPTEPIPAEELGEFDEMDD 1128

  Fly   439 ---VVR------------KSRNEYKNWLAAVGECERKDKKLMPRPHSLKD-----------CSSD 477
               :||            .|...:.:|:  :|..|    |..|.|.|::.           |:|.
Zfish  1129 EEGMVRVSVFPHDLRELLPSMKVWSDWM--LGHPE----KWNPPPCSMQGSPDVWQCLADLCNSF 1187

  Fly   478 SRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKSKRRGMRLRRRRRKIAQSD 542
            ||  .:.||....:..|||:. .|.:.....:|.|......||                 :|...
Zfish  1188 SR--VYHGEVLLYKADADGEG-DEELRVLQLEEDKMLSGFVPL-----------------LAAPQ 1232

  Fly   543 DSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGEERYAAANYSKK------- 600
            | :|| ::...|....:|.:..|.|....:.            .||:|....|....|
Zfish  1233 D-ACY-TDQGTDAAIAADCKRVTVLKYFLEA------------LCGQEEPLLAFKGGKYISMAAP 1283

  Fly   601 -------ERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSFEVLQ 658
                   |.||             .:.||.||.||..:..:|.|.....:...||:.:|.....:
Zfish  1284 LTPSINTENKA-------------QEQEDDVIVEESSLSASEGEIDGEMEGDGSEDDIRELRARR 1335

  Fly   659 --LNFKSAE------------------DAQSKPVAPPP-----VSFSEPPKKLVYRNKYTKINPN 698
              |..|.|:                  :.:.:|....|     :...|..:||:....|..:.|.
Zfish  1336 HALAHKLAQQQKRRDKIQAVLQTGGQLEIEVRPFYLVPDTNGFIDHLEGLRKLLACGTYILVVPL 1400

  Fly   699 IVIDCL--------------------------------------HNEPTIRALKMLFDWLRI--- 722
            |||..|                                      ..:|:||||....:.|..
Zfish  1401 IVITELDGLAKGQDSREGVGNGAHARQVQDRARAAVMFLEKAFESRDPSIRALTSRGNTLESIAF 1465

  Fly   723 -----------NPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVEL 776
                       |.::::.|             .|:||.   ...|.:...:......:|..:|.|
Zfish  1466 RSEDTSGQKGNNDDVILSC-------------CLHYCQ---DKAKDFMPAERNGPVRLRREVVLL 1514

  Fly   777 FDVR--------ANVPLTEDFAF 791
            .|.|        .|||:.:..||
Zfish  1515 TDDRNLRVKALTRNVPVRDIPAF 1537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_001285914.1	EST1	99..222	CDD:287360	21/122 (17%)
		EST1_DNA_bind	240..478	CDD:287359	60/337 (18%)
		PIN_Smg5	1012..1173	CDD:189054
smg6	XP_005172798.4	Neuromodulin_N	<150..>498	CDD:331332
		EST1	755..858	CDD:313576	24/129 (19%)
		EST1_DNA_bind	868..1227	CDD:313575	70/380 (18%)
		TPR repeat	882..910	CDD:276809	9/27 (33%)
		PIN_Smg6	1364..1541	CDD:189055	33/190 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12296
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910