DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Smap1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001344324.1	Gene:	Smap1 / 98366	MGIID:	2138261	Length:	467	Species:	Mus musculus

Alignment Length:	310	Identity:	87/310 - (28%)
Similarity:	124/310 - (40%)	Gaps:	81/310 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   710 RVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIG 774
            |...|.:|.||.|..|.|||.|:||.:||.|:|:|||||.|||:|:|:.||.|....:..|..:|
Mouse    26 REEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMG 90

  Fly   775 NSLANSVWESNTRQ--RVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEA 837
            |:.|..::|:|..:  |...|.||    .|.::|.|||.|::..
Mouse    91 NTKARLLYEANLPENFRRPQTDQA----VEFFIRDKYEKKKYYD--------------------- 130

  Fly   838 VIRADIKSIVSILANCPSEVTNANVSARD------VRTPLLLACAIGNLAIAQLLIWNGANIKHT 896
                  |:.::|          .|:|:.|      |.:|.|.|....|....:       ..|..
Mouse   131 ------KNAIAI----------TNISSSDAPLQPLVSSPSLQAAVDKNKLEKE-------KEKKK 172

  Fly   897 DHEGR------------TCLAYARAAQSLATAKSIKAAAAAQ-----AGTTIPAPAPPTNGGIPA 944
            |.:.|            |.....:..|.|...||.....||:     .|...||.||.|||
Mouse   173 DEKKREKEPEKPAKPLTTEKLPKKEEQQLEPKKSTSPKNAAEPTIDLLGLDGPAEAPVTNG---- 233

  Fly   945 PQYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTPYEKSVSGV 994
               |.....||.:.|:..|...:.||.|: .:|..:.|...|...::|.|
Mouse   234 ---NPATAPALSDDLDIFGPMISNPLPAA-VMPPAQGTASVPAPATLSTV 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	46/109 (42%)
		ANK	<834..907	CDD:238125	14/90 (16%)
		ANK repeat	834..866	CDD:293786	4/31 (13%)
		Ank_5	859..907	CDD:290568	12/65 (18%)
		ANK repeat	868..897	CDD:293786	5/28 (18%)
Smap1	NP_001344324.1	ArfGap	20..120	CDD:307528	41/97 (42%)
Smap1	NP_001344324.1	Med15	<343..>451	CDD:312941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810