DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and AGE2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_012220.3	Gene:	AGE2 / 854767	SGDID:	S000001306	Length:	298	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	88/291 - (30%)
Similarity:	129/291 - (44%)	Gaps:	55/291 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   696 ATSTDLAAMLAIRQRVPGNGFCVDCGAP-NPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGL 759
            :||..:...|:...|.|||..|.||.|. :|.|||.:|||.:||:|:|:||:||:|||||:|:.|
Yeast     2 STSVPVKKALSALLRDPGNSHCADCKAQLHPRWASWSLGVFICIKCAGIHRSLGTHISKVKSVDL 66

  Fly   760 DDWPSPHLSVMLAIGNSL-ANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPL----G 819
            |.|...||..::...|:| |||.:|:.....:|..........:.::::|||.|:::..|    |
Yeast    67 DTWKEEHLVKLIQFKNNLRANSYYEATLADELKQRKITDTSSLQNFIKNKYEYKKWIGDLSSIEG 131

  Fly   820 NGSSAHP---SPSPGQQLIEAVIRAD--IKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGN 879
            ...|..|   .||....|..:..|.|  ..|:.......||.:.:.:.|    .|.||      |
Yeast   132 LNDSTEPVLHKPSANHSLPASNARLDQSSNSLQKTQTQPPSHLLSTSRS----NTSLL------N 186

  Fly   880 LAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATA-------------KSI-----KAAAAAQ 926
            |.::.|       .|.|.:...|..|.:..|.:..|.             |||     |.:|..|
Yeast   187 LQVSSL-------SKTTSNTSVTSSATSIGAANTKTGNRVGEFGQRNDLKKSILSLYSKPSAQTQ 244

  Fly   927 A-----GTTIP----APAPPTNGGIPAPQYN 948
            :     .:|.|    .|:|..|.||.|...|
Yeast   245 SQNSFFTSTTPQPCNTPSPFVNTGITATNNN 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	46/117 (39%)
		ANK	<834..907	CDD:238125	17/74 (23%)
		ANK repeat	834..866	CDD:293786	7/33 (21%)
		Ank_5	859..907	CDD:290568	11/47 (23%)
		ANK repeat	868..897	CDD:293786	7/28 (25%)
AGE2	NP_012220.3	COG5347	1..298	CDD:227651	88/291 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810