DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and GTS1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_011334.1	Gene:	GTS1 / 852694	SGDID:	S000003149	Length:	396	Species:	Saccharomyces cerevisiae

Alignment Length:	320	Identity:	72/320 - (22%)
Similarity:	108/320 - (33%)	Gaps:	103/320 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 CVDCGAPNPEWASLNLGVLMCIECSGVHRNL-GSH----ISKVRSLGLDDWPSPHLSVMLAIGNS 776
            |.:||...|.|.|:||||.:|..|:.|||.: ||.    .|.|:||.:|.|....:..::::|.:
Yeast    30 CGECGNFYPTWCSVNLGVFLCGRCASVHRKVFGSRDDDAFSNVKSLSMDRWTREDIDELVSLGGN 94

  Fly   777 LANS-VW------------------ESNTRQR----------VKP----------TSQASREDKE 802
            ..|: .|                  |...|.:          :||          ..::.|.|:.
Yeast    95 KGNARFWNPKNVPFPFDGDDDKAIVEHYIRDKYILGKFRYDEIKPEDFGSRMDDFDGESDRFDER 159

  Fly   803 RWVRSKYEAKEFLTPLGN----GSSAHPSPSPG----QQLIEAVIRADIKSIVSILANCPSEVTN 859
            ...||:..:..|.....|    |.|.....|.|    :||.|             |.:.....||
Yeast   160 NRSRSRSRSHSFYKGGHNRSDYGGSRDSFQSSGSRYSRQLAE-------------LKDMGFGDTN 211

  Fly   860 ANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAA 924
            .|:.|        |:.|.||:                          .||...|..:.|.:.:.:
Yeast   212 KNLDA--------LSSAHGNI--------------------------NRAIDYLEKSSSSRNSVS 242

  Fly   925 AQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVE---LLEGLGCPEAAPLTASGTLPRRRD 981
            |.|.|:.| |.|........||..:.|.|.::.   ........:|.|....|||.:..|
Yeast   243 AAATTSTP-PLPRRRATTSGPQPAIFDGTNVITPDFTSNSASFVQAKPAVFDGTLQQYYD 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	35/144 (24%)
		ANK	<834..907	CDD:238125	11/72 (15%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	7/47 (15%)
		ANK repeat	868..897	CDD:293786	4/28 (14%)
GTS1	NP_011334.1	COG5347	8..310	CDD:227651	72/320 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900