DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and DOC2A

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_024306240.1	Gene:	DOC2A / 8448	HGNCID:	2985	Length:	467	Species:	Homo sapiens

Alignment Length:	436	Identity:	86/436 - (19%)
Similarity:	137/436 - (31%)	Gaps:	178/436 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 PLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQ--AEQKLWSLQAASSSTI 368
            |.|..|||     |:|..... |.||.:      ..|||...:...|  |.|:.|
Human   123 PGPVCVQP-----PEGAHSSF-PSQACS------FVLPLPPPSGLLQGPALQEGW---------- 165

  Fly   369 NENNNITKYNPGAANSLQGDCSQVQLRDPRD---LAPPPGKELPTPTSTPTTSRKSRRRSNLFIP 430
                   :..|||::.|  .|..:|...|.|   ||.|..|                    |.:.
Human   166 -------REVPGASSPL--PCPPLQGLKPMDFNGLADPYVK--------------------LHLL 201

  Fly   431 SSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEW----------------KKKYVTL 479
            ..:.||:|.|.                    |....:||..|                |...:.:
Human   202 PGACKANKLKT--------------------KTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAV 246

  Fly   480 CDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTS-SLMANGQRAQNT 543
            ||:.:|::    ::::.::   .:||:.:.   |.||...:..:.....|.| |.|:...|
Human   247 CDEDKLSH----NEFIGEI---RVPLRRLK---PSQKKHFNICLERQVPLASPSSMSAALR---- 297

  Fly   544 LSDGIGC----LTLAKDNQRKLSEK----LSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGI---- 596
               ||.|    |..|:..|..|.|:    |||                |.||::.....||
Human   298 ---GISCYLKELEQAEQGQGLLEERGRILLSL----------------SYSSRRRGLLVGILRCA 343

  Fly   597 ---AM-----SNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIV 653
               ||     |:...:|::..:|            :.|.:|:..........|.::...||..:.
Human   344 HLAAMDVNGYSDPYVKTYLRPDV------------DKKSKHKTCVKKKTLNPEFNEEFFYEIELS 396

  Fly   654 SLDSKQ-----WHFE---------------AANSEERDEWVAAVEQ 679
            :|.:|.     |.::               .|..|.|..|...::|
Human   397 TLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQ 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	52/286 (18%)
		PH	454..>521	CDD:278594	13/82 (16%)
		ArfGap	702..818	CDD:279720
		ANK	<834..907	CDD:238125
		ANK repeat	834..866	CDD:293786
		Ank_5	859..907	CDD:290568
		ANK repeat	868..897	CDD:293786
DOC2A	XP_024306240.1	C2A_Rabphilin_Doc2	90..280	CDD:176000	47/237 (20%)
DOC2A	XP_024306240.1	C2B_Rabphilin_Doc2	321..453	CDD:176030	26/150 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910