DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGD1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_201004.2	Gene:	AGD1 / 836319	AraportID:	AT5G61980	Length:	828	Species:	Arabidopsis thaliana

Alignment Length:	1001	Identity:	205/1001 - (20%)
Similarity:	328/1001 - (32%)	Gaps:	379/1001 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 ISNSLAIRQEIQRFESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSV 140
            :.:|...||::|..|          |..:||.:...:..:..|.:...:.:.:
plant     6 LDDSPMFRQQMQSME----------ESAELLRLRCLRFYKGCRKYTEGLGEGY------------ 48

  Fly   141 PDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFA 205
             |..:|.|.:|.|                    .||.....|.:           ..|.|.|
plant    49 -DADIGFVNALES--------------------FGGGHNDPVCV-----------AFGGPVM--- 78

  Fly   206 GWVDAVIFVFSLENEGSFNTV------YNYYTKMAHFRNG--QEIPMILVGTQDAISERNPRVID 262
                 ..|..:|...|::..|      :....::..|.||  .|:       ::|....:...|.
plant    79 -----TKFTIALREIGTYKEVLRSQVEHMLSDRLLQFVNGDVHEV-------KEARKRFDKATIT 131

  Fly   263 DTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLA 327
            ..:||:....|::.:..:..||                      :...:..||.|..|. |..|.
plant   132 YDQAREKYLSLRKSTRLDVAAT----------------------IEEDLHSARTTFEQA-RFHLV 173

  Fly   328 PYQAPTNGQ-----------RGQQQLPLRMSADFAQAEQKLWSLQAASSSTI---NENNNITKYN 378
              .|.:|.:           .|.....||.   |.|..:.|..::...:..:   :::.....|.
plant   174 --SALSNAESKKRFEFLEAVSGTMDAHLRF---FKQGYELLHQMEPFINQVLAYAHQSRECANYE 233

  Fly   379 PGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPK 443
            ..:.|....:..:...|:.|:....|         |....|.:.|.|...|.:..:.|.|
plant   234 MASLNERMQEYQRQVDRETRNSCVSP---------TGDGMRHNSRNSQKVIEAVMQSAAK----- 284

  Fly   444 SSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYV 508
                  |:...|:||||.|||| :|..:||:::..|...|.|.|:
plant   285 ------GKVQTIRQGYLSKRSS-NLRGDWKRRFFILDSRGMLYYY-------------------- 322

  Fly   509 TVKVPGQKP------RGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSL 567
                  :||      .||:|::..:..:.:            |.|:            ||..||.
plant   323 ------RKPWNWSSGNGSRSVVHRNMASEN------------SPGL------------LSRWLSS 357

  Fly   568 LGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRM 632
            ...|.:                            :.:..:|....|                  :
plant   358 HYHGGV----------------------------HDEKPVARHTVN------------------L 376

  Fly   633 KSSSVKANEADDND-GYEFYIVSLDSKQWHFEAANSEERDEWVAAV-------------EQEIFK 683
            .:|::|. :||..| .:.|.|:| .:|.:..:|.|::::.:|:..:             |:.|.:
plant   377 LTSTIKV-DADQTDLRFCFRIIS-PTKVYTLQAENAQDQMDWIEKITGVIASLLSFQTPERAIMR 439

  Fly   684 SLQSIESSKTKQAT-STDLAAMLAIRQ-------------------------------------- 709
             |.:::...|..|: |..||....|.|
plant   440 -LSTVDGGDTFSASDSGSLADPYDIEQAESGESTVEHPMTGGNRSRFSGCLQQHDMVKTEKPIDV 503

  Fly   710 --RVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLD--DWPSPHLSVM 770
              ||.||..|.|||||.|:|||||||||:||||||:|||||.||||||||.||  .|....|::.
plant   504 LTRVLGNERCADCGAPEPDWASLNLGVLICIECSGIHRNLGVHISKVRSLTLDVKVWEPSVLTLF 568

  Fly   771 LAIGNSLANSVWES--NTRQRVKPTSQASRED------------------------KERWVRSKY 809
            .::||...|||||.  |:..|   ||.|||..                        ||.::.:||
plant   569 QSLGNVYVNSVWEELLNSESR---TSSASRSSGTPKSDRPRKLLVRKPGFNDPISVKELFIHAKY 630

  Fly   810 EAKEFLTPL----------------------------------------GNGSSAHPSPSPGQQL 834
            ..:.|:...                                        |..|.....|......
plant   631 SERIFVRKAIDSQHFQAVFQEIWENVRANDKKSVYRHIVCSEADVNALRGQASYTVSLPLSKMMQ 695

  Fly   835 IEAVIRADIKSIVSILANCPSEVTNANVSARD-VR-------TPLLLACAIGNLAIAQLLIWNGA 891
            :|..:.|..|||.......|:..:|:...... ||       :.|.|||...::.:.:||:..||
plant   696 MEETLEAKFKSIEEEFQENPAGYSNSRGDGESMVREETSNDCSLLHLACLSADIGMVELLLQYGA 760

  Fly   892 NIKHTDHEGRTCLAYARAAQSLATAK 917
            .|..||.:|||.|.:...::..|.|:
plant   761 KINATDSKGRTPLHHCIISRRYAIAR 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	25/164 (15%)
		RAS	144..295	CDD:214541	25/158 (16%)
		PH_AGAP	451..686	CDD:241281	44/254 (17%)
		PH	454..>521	CDD:278594	19/72 (26%)
		ArfGap	702..818	CDD:279720	65/183 (36%)
		ANK	<834..907	CDD:238125	24/80 (30%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	18/55 (33%)
		ANK repeat	868..897	CDD:293786	10/35 (29%)
AGD1	NP_201004.2	BAR_SFC_plant	15..215	CDD:153290	46/296 (16%)
		PH	289..425	CDD:278594	42/234 (18%)
		PH_ACAP	291..429	CDD:270070	41/236 (17%)
		ArfGap	498..639	CDD:279720	62/143 (43%)
		ANK	734..>826	CDD:238125	17/53 (32%)
		Ank_4	738..789	CDD:290365	17/49 (35%)
		ANK repeat	740..766	CDD:293786	9/25 (36%)
		ANK repeat	768..799	CDD:293786	6/19 (32%)
		Ank_4	769..823	CDD:290365	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I2005
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820