DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Acap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_006522806.1	Gene:	Acap2 / 78618	MGIID:	1925868	Length:	816	Species:	Mus musculus

Alignment Length:	790	Identity:	171/790 - (21%)
Similarity:	269/790 - (34%)	Gaps:	263/790 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 MSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPT 410
            :..|.|:.|.||..|.....:.|:........|....|.:            ||||.....:...
Mouse    24 VEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGI------------RDLAQYSSNDAVV 76

  Fly   411 PTST------------------PTTSRKSRRRSNLFIPSSSKK---ADKEKEPKSSELGSGRSIP 454
            .||.                  ..|.|..:.:...|:....:|   |.|:.|..|.|
Mouse    77 ETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEE-------- 133

  Fly   455 IKQGYLYKRSSKSLNKEWK-KKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYV-TVKVPGQKP 517
             |:..|.|.:....||:.: ::...:....|..:             :.|.|.|| .:.|...|.
Mouse   134 -KENALVKNAQVQRNKQHEVEEAANILTATRKCF-------------RHIALDYVLQINVLQSKR 184

  Fly   518 RGS--KSIIT---------------NSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKL 565
            |..  ||:::               .|.|...:...|.:....:.|       |...:|::.:|.
Mouse   185 RSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVD-------AAKEKREMEQKH 242

  Fly   566 SLLGAGSIAAGAGGEPLKSNSSQ---QTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKK 627
            |     :|...|..:...|:.|:   ......||.|     :.::....:||......:.|:..:
Mouse   243 S-----TIQQKAALQDFSSDDSKLEYNVDAANGIVM-----EGYLFKRASNAFKTWNRKKPDHIR 297

  Fly   628 R-----------HRRMKSS-----------SVKANEADDNDGYEFYIVSLDSKQWHFEAANSEER 670
            |           .::.|.|           :||..| |....:.|.:|| .:|....:|.:.:.|
Mouse   298 RWFSIQNNQLVYQKKFKDSPTVVVEDLRLCTVKHCE-DIERRFCFEVVS-PTKSCMLQADSEKLR 360

  Fly   671 DEWVAAVEQEIFKSL--QSIESSKTKQATSTDLAAM----------------LAIRQRVPGNGFC 717
            ..|:.||:..|..:.  :..||.|..:.:|....::                |...|.:|||..|
Mouse   361 QAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNTSC 425

  Fly   718 VDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVW 782
            .|||..:|.|||:|||:.:||||||:||:||.|.||||||.||.|....|.:|..:||.:.|.|:
Mouse   426 CDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVY 490

  Fly   783 ESN-TRQRVKPTSQASREDKERWVRSKYEAKEFL------------------------------- 815
            |:. .:..||......|::||.::|:||..::|:
Mouse   491 EAKLEKMGVKKPQPGQRQEKEAYIRAKYVERKFVDKYSALLSPSEQEKRIISKSCEDQRLSHARA 555

  Fly   816 ---TPLG----------------------------------------------NGSSAHPSP--- 828
               ||:.                                              :|..:.||.
Mouse   556 SVHTPVAAVTSDEARRESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQCSEDGRESLPSTVSA 620

  Fly   829 ----------------------SPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPL 871
                                  :||.||..|....::..:...||: .::|..|| |..:..|||
Mouse   621 NSLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAH-GADVNWAN-SDENQATPL 683

  Fly   872 LLACAIGNLAIAQLLIWNGANIKHTD--------------HEGRTCLAYARAAQSLATAKSIK-- 920
            :.|...|:|...:.|:.||||:...|              |.|:.||...|.|...||.:..|
Mouse   684 IQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDP 748

  Fly   921 ---AAAAAQA 927
               |..||.|
Mouse   749 LSIAVEAANA 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	50/280 (18%)
		PH	454..>521	CDD:278594	13/70 (19%)
		ArfGap	702..818	CDD:279720	53/166 (32%)
		ANK	<834..907	CDD:238125	24/86 (28%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		Ank_5	859..907	CDD:290568	19/61 (31%)
		ANK repeat	868..897	CDD:293786	11/28 (39%)
Acap2	XP_006522806.1	BAR_ACAP2	18..217	CDD:153322	41/226 (18%)
		PH_ACAP	273..376	CDD:270070	21/109 (19%)
		COG5347	398..>635	CDD:227651	57/236 (24%)
		ArfGap_ACAP2	410..524	CDD:350076	51/113 (45%)
		Ank_4	648..699	CDD:372654	14/52 (27%)
		ANK repeat	676..709	CDD:293786	11/32 (34%)
		PTZ00322	680..>764	CDD:140343	25/79 (32%)
		ANK repeat	711..742	CDD:293786	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950