DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Arfgap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001159496.1	Gene:	Arfgap2 / 77038	MGIID:	1924288	Length:	534	Species:	Mus musculus

Alignment Length:	274	Identity:	70/274 - (25%)
Similarity:	110/274 - (40%)	Gaps:	56/274 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 TSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLD- 760
            :.|::..:....:.:|.|..|.||||.:|.|||:..||.:||:||||||:||.|:|.:||..||
Mouse     6 SKTEIQTIFKRLRAIPTNKACFDCGAKSPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDS 70

  Fly   761 DWPSPHLSVMLAIGNSLANSVW--------ESNT----------RQRVKPTSQA--SREDKERWV 805
            :|....|..|...||:.|.:.:        ::||          |::::....|  :|...:.|:
Mouse    71 NWSWLQLRCMQVGGNANATAFFRQHGCMANDANTKYTSRAAQMYREKIRQLGSAALTRHGTDLWI 135

  Fly   806 RSKYEA---------KEFLT-----------------------PLGNGSSAHPSPSPGQQLIEAV 838
            .|...|         .:|.|                       |..:.|.|.|...|...|:...
Mouse   136 DSMNSAPSHSPEKKDSDFFTEHTQAPAWDTAATDPSGTQQPALPSESSSLAQPEQGPNTDLLGTS 200

  Fly   839 IRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTC 903
            .:|.::|:. :.|..||.......|....:.|......:|  |...|.....:|...|:.|.:..
Mouse   201 PQASLESMY-LSAKGPSCTRELKSSIIGKKKPAAAKKGLG--AKKGLGAQKVSNQSFTEIERQAQ 262

  Fly   904 LAYARAAQSLATAK 917
            :|.....|..|.||
Mouse   263 VAEKLREQQAADAK 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	45/168 (27%)
		ANK	<834..907	CDD:238125	15/72 (21%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	9/47 (19%)
		ANK repeat	868..897	CDD:293786	5/28 (18%)
Arfgap2	NP_001159496.1	PLN03114	3..484	CDD:178661	70/274 (26%)
Arfgap2	NP_001159496.1	ArfGap	11..117	CDD:279720	38/105 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900