DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGAP5

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001137472.1	Gene:	AGAP5 / 729092	HGNCID:	23467	Length:	686	Species:	Homo sapiens

Alignment Length:	843	Identity:	277/843 - (32%)
Similarity:	373/843 - (44%)	Gaps:	209/843 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QRFESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSL 151
            |:..||.||...|||......||.|.:|.:::...|.:|
Human    19 QQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVE-------------------------- 57

  Fly   152 NSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFS 216
             .|:...:|.     ...:|.||...|.            |..:...:...|.....||:.|..|
Human    58 -VGEDLHMHH-----IRDQEMPEALEFS------------LSANPEASTIFQRNSQTDALEFNPS 104

  Fly   217 LENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYET 281
            ...|.|  |::.        ||.|         .|.:..|.....:.....:.:..      |.:
Human   105 ANPEAS--TIFQ--------RNSQ---------TDVVEIRRSNCTNHVSTERFSQQ------YSS 144

  Fly   282 CATYGLNVERVFQD-ACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLR 345
            |:|..|:.....|. ....|:|..|.:|..:     |....:|....|
Human   145 CSTIFLDDSTASQHYLTMTIISVTLEIPHHI-----TQRDADRSLSIP----------------- 187

  Fly   346 MSADFAQAEQKLWSLQAASSSTINEN-------NNITKYNPGAANSLQGDCSQVQLRDPRDLAPP 403
                    :::|.|. |.|:..|.:|       ||.:...|...::.|        .||: .:.|
Human   188 --------DEQLHSF-AVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQ--------EDPQ-FSVP 234

  Fly   404 PGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEK---EPKSSELGSGRSIPIKQGYLYKRSS 465
            |....|||     ..::|.|.||||........|||:   |..:..:||||:||||||.|.|||.
Human   235 PTANTPTP-----VCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSG 294

  Fly   466 KSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNS-AL 529
            |.| |.|||||||||.:|.|||:.||.|||.::|.|||.|:..|:||||:.|    |:.|:: |.
Human   295 KWL-KTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWP----SLATSACAP 354

  Fly   530 TSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDE 594
            .||..:||               |:||                :..|.|               :
Human   355 ISSSKSNG---------------LSKD----------------MDTGLG---------------D 373

  Fly   595 GIAMSNSNSQTFIAGEVANAGNKLE-AQTPNV-KKRHRRMKSSSVKANEADDNDGYEFYIVSLDS 657
            .|..|.|.|.|        ...||. ..:|:. ||:|.:.||::            .|.|||...
Human   374 SICFSPSISST--------TSPKLNPPPSPHANKKKHLKKKSTN------------NFMIVSATG 418

  Fly   658 KQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTK-QATSTDLAAMLAIRQRVPGNGFCVDCG 721
            :.|||||...||||.||.|::.:|..||||.||||:| |.||...|..|...|.:.||..|||..
Human   419 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYE 483

  Fly   722 APNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNT 786
            ..||:||||||||||||||||:||:||:.:|:||||.|||||.....||.:|||.||||:||.::
Human   484 TQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSS 548

  Fly   787 RQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSP--SPGQQLIEAVIRADIKSIVSI 849
            :.:.||:.:::||:||||:|||||.|.||.||       |..  |.||.|:.|....|:::.:.:
Human   549 QGQTKPSVKSTREEKERWIRSKYEEKLFLAPL-------PCTELSLGQHLLRATADEDLQTAILL 606

  Fly   850 LANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQS 912
            ||:...|..|......|..|.|.|||..||:.:||||||.|.::...|..|.|.|.|||.|.|
Human   607 LAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASS 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	25/157 (16%)
		RAS	144..295	CDD:214541	24/150 (16%)
		PH_AGAP	451..686	CDD:241281	86/237 (36%)
		PH	454..>521	CDD:278594	41/66 (62%)
		ArfGap	702..818	CDD:279720	67/115 (58%)
		ANK	<834..907	CDD:238125	26/72 (36%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	20/47 (43%)
		ANK repeat	868..897	CDD:293786	14/28 (50%)
AGAP5	NP_001137472.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..242		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..278		4/21 (19%)
		PH_AGAP	280..447	CDD:241281	86/237 (36%)
		PH	283..442	CDD:278594	82/229 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..404		8/29 (28%)
		ArfGap	466..580	CDD:279720	66/113 (58%)
		ANK	<590..677	CDD:238125	31/80 (39%)
		Ank_2	591..681	CDD:289560	31/79 (39%)
		ANK repeat	591..621	CDD:293786	7/29 (24%)
		ANK repeat	623..654	CDD:293786	15/30 (50%)
		ANK 1	623..652		15/28 (54%)
		ANK 2	656..685		8/14 (57%)
		ANK repeat	656..681	CDD:293786	8/14 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4206
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.780