DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Arhgap26

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_036017177.1	Gene:	Arhgap26 / 71302	MGIID:	1918552	Length:	823	Species:	Mus musculus

Alignment Length:	801	Identity:	137/801 - (17%)
Similarity:	243/801 - (30%)	Gaps:	321/801 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGS 222
            ||::.:|.:|.:|||               .|..|...:..:.:.:||   |::       ||..
Mouse    38 LVYKNITLTYFREES---------------GYFWLRYMDLSSAKRKFA---DSL-------NEFK 77

  Fly   223 FNTVYNYYT--KMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATY 285
            |..:.:..|  :|...|:.||...:|            |.::|.|:|.:.
Mouse    78 FQCIGDAETDDEMCIARSLQEFAAVL------------RNLEDERSRMIE--------------- 115

  Fly   286 GLNVERVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADF 350
              |...|.....:|...:      |:..||....:        |...|....|..:..|.:|
Mouse   116 --NASEVLITPLEKFRKE------QIGAAREAKKK--------YDKETEKYCGTLEKHLNLS--- 161

  Fly   351 AQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPP------------ 403
              :::|...||.|.|.......:..:.:......:|    :||.|...:...|
Mouse   162 --SKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQ----EVQERKMFEFVEPLLAFLQGLFTFY 220

  Fly   404 -PGKELPT-----PTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIP-IKQGYLY 461
             .|.||..     .|....:.:.:|.|   |..:.|:.....|:.|.:.|......| ..:||||
Mouse   221 HHGYELAKDFGDFKTQLTISIQNTRNR---FEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLY 282

  Fly   462 KRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITN 526
            .:..:.....|.|.|.|.                                     .|.||.|
Mouse   283 VQEKRHFGTSWVKHYCTY-------------------------------------QRDSKQI--- 307

  Fly   527 SALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTS 591
                                     |:...:|:              :.|.|||
Mouse   308 -------------------------TMVPFDQK--------------SGGKGGE----------- 322

  Fly   592 GDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKAN-----EADDNDGYEFY 651
             ||.:.:                            |...|.|:.|::..     ||.|..|
Mouse   323 -DESVTL----------------------------KSCTRRKTDSIEKRFCFDVEAVDRPG---- 354

  Fly   652 IVSLDSKQWHFEAANSEERDEWVAAVE--QEIFKSLQSIESSKTKQATSTDLAAMLAIRQRVPGN 714
            ::::       :|.:.|:|..|:.|::  :.::.|.:..:|..|.|..|.
Mouse   355 VITM-------QALSEEDRRLWMEAMDGREPVYNSNRDSQSEGTAQLDSI--------------- 397

  Fly   715 GFCVDCGAPNPEWASLNLGVLMCIEC--------SGVHRNLG--SHISKVRSLGLDDWPSPHLSV 769
            ||.:               :..||..        .|::|.:|  |.:.|:.|:.:|...:.....
Mouse   398 GFSI---------------IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETET 447

  Fly   770 MLAIGNSLANSVWE-------SNTRQRVKPTSQASREDKERWVR-SKYEAKEFLTPLGN-GSSAH 825
            .:.       :.||       ..|..|:.|......:.:..::: :|.|.:|  |.:.. .|..|
Mouse   448 DIC-------AEWEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQE--TRVSEIHSLVH 503

  Fly   826 PSPSPGQQLIEAVIRADIKSIVSILANCPSE-----VTNANVSARDVRTPLLL------ACAIGN 879
            ..|...:|:::.        :::.|||..:.     :|.||:..  |..|.||      ..||.:
Mouse   504 RLPEKNRQMLQL--------LMNHLANVANNHKQNLMTVANLGV--VFGPTLLRPQEETVAAIMD 558

  Fly   880 L----AIAQLLIWNGANIKHT 896
            :    .:.::||.|...|.:|
Mouse   559 IKFQNIVIEILIENHEKIFNT 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	27/143 (19%)
		RAS	144..295	CDD:214541	27/138 (20%)
		PH_AGAP	451..686	CDD:241281	35/242 (14%)
		PH	454..>521	CDD:278594	10/67 (15%)
		ArfGap	702..818	CDD:279720	20/133 (15%)
		ANK	<834..907	CDD:238125	17/78 (22%)
		ANK repeat	834..866	CDD:293786	6/36 (17%)
		Ank_5	859..907	CDD:290568	13/48 (27%)
		ANK repeat	868..897	CDD:293786	10/39 (26%)
Arhgap26	XP_036017177.1	BAR	61..234	CDD:416402	40/234 (17%)
		BAR-PH_GRAF_family	276..380	CDD:269953	33/233 (14%)
		RhoGAP_Graf	373..572	CDD:239839	43/247 (17%)
		SH3_GRAF	768..823	CDD:212997
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910