DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenG1A and arhgap10

DIOPT Version :9

Sequence 1:NP_723849.1 Gene:CenG1A / 34803 FlyBaseID:FBgn0028509 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_001038715.1 Gene:arhgap10 / 692277 ZFINID:ZDB-GENE-060512-221 Length:764 Species:Danio rerio


Alignment Length:709 Identity:136/709 - (19%)
Similarity:218/709 - (30%) Gaps:263/709 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   394 LRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQG 458
            |.:.|||.      :...|.|.....::.|:.:|    .|.||:::|..|.:|            
Zfish    97 LEEQRDLM------MRNITETLMKPLENFRKEHL----GSAKAERKKYEKETE------------ 139

  Fly   459 YLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDV-------HGKEIPLQYVTVKVPGQK 516
            ..|....|.||...|||            .|.|.:  .||       |.:|..|:||......|:
Zfish   140 KYYSSLEKLLNMSAKKK------------EPQLQE--ADVSVELMRQHFQETSLEYVCKLQEIQE 190

  Fly   517 PRGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLAK--DNQRKLSEKLSLLGAGSIAAGAGG 579
            .:..:.:       ..::|..|........|   ..|||  |:.:|                   
Zfish   191 RKKFECV-------EPMLAFFQTVFTFYHQG---YELAKDFDHYKK------------------- 226

  Fly   580 EPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSS--SVKANEA 642
             .|:.|                         :.|..|:.|.....|.:..:|:|.|  ..:....
Zfish   227 -ALQIN-------------------------IQNTRNRFEGTRSEVFELMKRIKESPQDYRQTSP 265

  Fly   643 DDNDGYEFYIVSLDSKQWHFEAANSEER-----DEWVA-----AVEQEI--FKSLQSIESSKTKQ 695
            ..::|| .|:              .|:|     ..||.     ..||:|  .|:.......|..:
Zfish   266 ISSEGY-LYV--------------QEKRPPPFGSSWVKRYSTFVKEQKILHMKTFDQRSGGKLGE 315

  Fly   696 ATSTDLAAMLAIRQRVPGNGFCVD---------------------------CGAPNPEWASLN-- 731
            ..|..|.:.:..........||:|                           .|...| ...||  
Zfish   316 TESVTLKSCVRKTTDALDRRFCLDIEITDRPGTVLTVQALSEDDHKFWMHAMGGKEP-MQCLNRT 379

  Fly   732 -------------LGV------LMCIECSGV-----HRNLG--SHISKVRSLGLDDWPSPHLSVM 770
                         :|:      :..||..|:     :|.:|  |.:.|:.||.:|:..|   .:.
Zfish   380 HSRERGIDAQLDDVGISFVKNSINAIEARGINDQGLYRVVGVSSKVQKLLSLMIDEKSS---DID 441

  Fly   771 LAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRS------KYEA-KEFLTPLGNGSS----- 823
            |:     ||..|:      ||..:.|.:    .::||      .||. |||:.|..:.|.     
Zfish   442 LS-----ANEDWD------VKTITSALK----LYLRSLPEPLMTYELYKEFIVPAKSASPESRVQ 491

  Fly   824 -----AHPSPSPGQQLIEAVIRADIKSIVSILANCPSE-VTNANVSARDVRTPLLL------ACA 876
                 .|..|...:.::..|    .|.:.::.||.... :|.||:..  |..|.|:      ..|
Zfish   492 AIHCLVHKLPEKNRLVLSLV----TKHLANVAANSKQNLMTVANLGV--VFGPTLMRPQEETVAA 550

  Fly   877 IGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPP---- 937
            |.:|....:::    .|....||           :....|.|...:.|     |.|..||.    
Zfish   551 IMDLKFQNIVV----EILIEQHE-----------KIFGDAPSSSPSLA-----TTPLSAPTRQSK 595

  Fly   938 --TNGGIPAPQYN--VEDTTALVELLEGLG-CPEAAPLTASGTL-PRRRDTLGTPYEKS 990
              :....|...||  |.|...:....|..| |.:...:.::.:: .:..:..|||.|||
Zfish   596 RLSRQTRPLAVYNPQVLDIQTVSPSSESAGLCNDETSVGSNESVSSQSSNASGTPPEKS 654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenG1ANP_723849.1 SelP_N <5..41 CDD:282453
Centaurin_gamma 143..300 CDD:133303
RAS 144..295 CDD:214541
PH_AGAP 451..686 CDD:241281 45/257 (18%)
PH 454..>521 CDD:278594 17/73 (23%)
ArfGap 702..818 CDD:279720 33/177 (19%)
ANK <834..907 CDD:238125 16/79 (20%)
ANK repeat 834..866 CDD:293786 7/32 (22%)
Ank_5 859..907 CDD:290568 11/53 (21%)
ANK repeat 868..897 CDD:293786 6/34 (18%)
arhgap10NP_001038715.1 BAR_GRAF2 19..225 CDD:153319 38/173 (22%)
BAR-PH_GRAF_family 267..373 CDD:269953 19/121 (16%)
PH 269..367 CDD:278594 17/112 (15%)
RhoGAP 367..566 CDD:295372 48/227 (21%)
SH3 710..763 CDD:302595
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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