DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and Asap3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_038967221.1	Gene:	Asap3 / 684122	RGDID:	1593929	Length:	903	Species:	Rattus norvegicus

Alignment Length:	1030	Identity:	201/1030 - (19%)
Similarity:	326/1030 - (31%)	Gaps:	404/1030 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AAASASGAPSSSASASASASILVAHPPQPLISNSLAIRQEIQR-FESVHPSIYAIYELIDLLPMA 109
            |||.|:..|....:|.|...:|         ....||.|.|:: ..::|.|           .:.
  Rat    24 AAAFAAKMPRCRGAALAREEVL---------EGDQAILQRIKKAVRAIHSS-----------GLG 68

  Fly   110 DAQIAQSIRDHVVCIEDSFV--NSQEWT--------ISRSVPDLRLGIVGSLNSGKSALVHRYLT 164
            ..:..:..|:.|..:.:|.:  ||.|.:        .:|.|..|...:|.:||:..|..:...:.
  Rat    69 HVETEEHYREAVEALGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDNLMK 133

  Fly   165 GSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNY 229
            | ::::     ||...:..::                   ..|.|                   |
  Rat   134 G-HLRD-----GRHDSKKHLE-------------------KAWKD-------------------Y 154

  Fly   230 YTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQ 294
            .||:|.....::......|:..|:|:       ||:..:....|..|.|..
  Rat   155 ETKVAKLEKERDRARFPGGSHGAMSQ-------DTQRERRVFQLHMCEYLV-------------- 198

  Fly   295 DACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWS 359
                                                     :.|:.|  ::...||.|:..|.:.
  Rat   199 -----------------------------------------KAGESQ--VKQGPDFLQSLIKFFH 220

  Fly   360 LQ---------AASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTP 415
            .|         ||.|        ::.:....|.|:.|      ||..::      :||     ..
  Rat   221 AQHNFFQDGWKAAQS--------LSPFIDKLAASVHG------LRQAQE------EEL-----HK 260

  Fly   416 TTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSI----------PIKQGYLYKRSSKSLNK 470
            .|..:...|..|.:.|      :|:.|.....|.|.||          ..|.|:|||:|. .:.:
  Rat   261 LTQLRDSLRGMLHLES------REEHPNRKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSD-GIRR 318

  Fly   471 EWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMA 535
            .|:|                          ::..::|
  Rat   319 VWQK--------------------------RKCGVKY---------------------------- 329

  Fly   536 NGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSN 600
                         ||||::.....:...||:||
  Rat   330 -------------GCLTISHSMVNRPPVKLALL-------------------------------- 349

  Fly   601 SNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHFEAA 665
                                             :..|:.|..|...   |.:|: .::.:||.|.
  Rat   350 ---------------------------------TCQVRPNPEDKRC---FDLVT-HNRTYHFHAE 377

  Fly   666 NSEERDEWVAAVEQEIFKSLQSI---ESSKTKQATST-------DLAAMLA--IRQRVPGNGFCV 718
            :..|.:.||:.::....::|.|.   |.|..:.:..|       ||..||.  ::.| |||..|.
  Rat   378 DELECEAWVSVLQNSKDEALSSAFHGEPSGGQWSWGTRLDTEPHDLTNMLVAEVKSR-PGNDHCC 441

  Fly   719 DCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWE 783
            ||||.:|.|.|.|||||.||:||||||.||...|:::||.||......|.:.|.||||..|.|.|
  Rat   442 DCGAADPTWLSTNLGVLTCIQCSGVHRELGVRYSRIQSLTLDLLGPSELLLALNIGNSHFNEVME 506

  Fly   784 SN--TRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSI 846
            ::  :....||::::....:..::.:||...:|        :...:|.| |:|..|:...|:.|:
  Rat   507 AHLPSHGSPKPSAESDMSSRRNYIVAKYVEHKF--------ARRSTPEP-QKLRTAICSRDLLSV 562

  Fly   847 VSILAN--------------CPSEVT------------------------NANVSARDVRTPLLL 873
            :...||              .|.|:.                        :.:..|.|..|.|..
  Rat   563 LEAFANGQDFGQLLPGPDGQAPGELALHLAIRVASQASLPIVDFLIQNGGHLDAKAADGNTALHC 627

  Fly   874 ACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGT-TIPAPAPP 937
            |...|.|...:||:...|.:...::.|.|.|..||..|.....:.::   .||||| ..|.|...
  Rat   628 AALHGQLDCLKLLLKGRAPMGAVNNAGETALDVARNKQHKDCEELLE---QAQAGTLAFPLPMDY 689

  Fly   938 TNGGIPAPQYNVEDTTALVELLEGLGCPEAAPLTA---SGTLP---RRRDTLGTP 986
            ..|......::.|:..      |...||...|..|   ||.|.   |..:|:..|
  Rat   690 HWGHSMDHGFDSEEEE------EEKHCPVKPPAQACWSSGRLDISNRTYETVANP 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	22/156 (14%)
		RAS	144..295	CDD:214541	21/150 (14%)
		PH_AGAP	451..686	CDD:241281	30/244 (12%)
		PH	454..>521	CDD:278594	9/66 (14%)
		ArfGap	702..818	CDD:279720	48/119 (40%)
		ANK	<834..907	CDD:238125	21/110 (19%)
		ANK repeat	834..866	CDD:293786	9/69 (13%)
		Ank_5	859..907	CDD:290568	13/47 (28%)
		ANK repeat	868..897	CDD:293786	8/28 (29%)
Asap3	XP_038967221.1	BAR_ASAP3	35..243	CDD:153324	49/343 (14%)
		PH_ASAP	294..400	CDD:270071	29/242 (12%)
		ArfGap_ASAP3	423..543	CDD:350087	49/128 (38%)
		ANK repeat	550..583	CDD:293786	6/32 (19%)
		ANK repeat	585..618	CDD:293786	1/32 (3%)
		Ank_2	589..674	CDD:403870	16/84 (19%)
		ANK repeat	620..651	CDD:293786	9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920