DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and Agap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_038935796.1	Gene:	Agap2 / 65218	RGDID:	628844	Length:	1304	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	353/962 - (36%)
Similarity:	481/962 - (50%)	Gaps:	215/962 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 VNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLI 193
            |||||||:|||:|:||||::|.:.||||:|:||:|||||...|.||..::|||:.:|||::|:||
  Rat   387 VNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKPESEQYKKEMLVDGQTHLVLI 451

  Fly   194 RDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQE--IPMILVGTQDAISER 256
            |:|.|||:.:|:||.||||||||||:|.||..|.:.:.::...|....  :.:.||||||.||..
  Rat   452 REEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSHLHGQLISLRGEGRGGLALALVGTQDRISAS 516

  Fly   257 NPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQR-----------LPLPPQ 310
            :|||:.|.|||.|.:|:||||||||||||||||:||||:..||:::.|           ||..|.
  Rat   517 SPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPS 581

  Fly   311 VQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNIT 375
            ...|  :||...       ||...|........|..|.:....|.:..:...|..||
  Rat   582 HSAA--STPVAG-------QASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLST-------- 629

  Fly   376 KYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEK 440
               ||:.:                                   |.::||::||  ::.:.:|.||
  Rat   630 ---PGSLH-----------------------------------RAAKRRTSLF--ANRRGSDSEK 654

  Fly   441 ---EPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKE 502
               :.:....||||:|||||.:|.|||..|||||||||||||..:|.|.||||::||:...||||
  Rat   655 RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKE 719

  Fly   503 IPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSL 567
            :.|...||||||::|..:.|....||..:.|:.:....|
  Rat   720 MDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQ-------------------------- 758

  Fly   568 LGAGSIAAGAGGEPLKSNSS-----QQTS-----GDEGIAMSNSNSQTFIAGEVANAGNKLEAQT 622
            :|.|..|:.....|..|.||     .|||     .|..:|.:.|...| .:|:::....: ...:
  Rat   759 MGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCT-PSGDLSPLSRE-PPPS 821

  Fly   623 PNVKKRHRRMKS-------SSVKAN------------------EADDNDGYEFYIVSLDSKQWHF 662
            |.|||:.|:..|       |:|:|.                  :|::|  :||.|||...:.|||
  Rat   822 PMVKKQRRKKLSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEEN--FEFLIVSSTGQTWHF 884

  Fly   663 EAANSEERDEWVAAVEQEIFKSLQSIESSKTKQAT--STDLAAMLAIRQRVPGNGFCVDCGAPNP 725
            |||:.||||.||.|:|.:|..|||..||||.|..|  .::..|:.||| ...||..|||||||||
  Rat   885 EAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIR-NAKGNSTCVDCGAPNP 948

  Fly   726 EWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRV 790
            .|||||||.|:||||||:|||||:|:|:||||.|||||.....|:.||||..||.||||:||.|.
  Rat   949 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRA 1013

  Fly   791 KPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSP-GQQLIEAVIRADIKSIVSILANCP 854
            |||..:|||::|.|:|:|||...||.|||.      :..| |:||..||...|:.:::.:||:..
  Rat  1014 KPTRDSSREERESWIRAKYEQLLFLAPLGT------TEEPLGRQLWAAVEAQDVAAVLLLLAHAR 1072

  Fly   855 SEVTNANVSARDVRTPLLLACAIGNLAIAQLLIW------------------------------- 888
            ....:.:|....:|:||.||..:.::.|.|||:|
  Rat  1073 HGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWVRERRVWRRRGGPRCAGPHSIVLRPPGWQPA 1137

  Fly   889 ------------NGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAA---QAGTTIPA----P 934
                        .|....|....|.....| |.||..|..:..:..:..   :||.....    |
  Rat  1138 MCRHPPPARLSGRGRQYSHHAQRGHHPQHY-RHAQPEAPEQCCQLGSRGHHDRAGIVAQPRERHP 1201

  Fly   935 APPTNGGIPAPQYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTP 986
            :||...|...|...::..|             .:||.::   ||....|.||
  Rat  1202 SPPRGPGTTTPGGPLDRCT-------------HSPLQSA---PRPTGALSTP 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	90/158 (57%)
		RAS	144..295	CDD:214541	87/152 (57%)
		PH_AGAP	451..686	CDD:241281	95/269 (35%)
		PH	454..>521	CDD:278594	41/66 (62%)
		ArfGap	702..818	CDD:279720	73/115 (63%)
		ANK	<834..907	CDD:238125	20/115 (17%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	14/90 (16%)
		ANK repeat	868..897	CDD:293786	12/71 (17%)
Agap2	XP_038935796.1	PRK07764	<37..174	CDD:236090
		Centaurin_gamma	401..560	CDD:133303	90/158 (57%)
		PH_AGAP	668..908	CDD:241281	95/269 (35%)
		ArfGap_AGAP	926..1033	CDD:350065	69/107 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3515
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	687	1.000	Inparanoid score	I669
OMA	1	1.010	-	-		QHG48005
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46067
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840