DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenG1A and ARAP3

DIOPT Version :9

Sequence 1:NP_723849.1 Gene:CenG1A / 34803 FlyBaseID:FBgn0028509 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_071926.4 Gene:ARAP3 / 64411 HGNCID:24097 Length:1544 Species:Homo sapiens


Alignment Length:642 Identity:150/642 - (23%)
Similarity:226/642 - (35%) Gaps:207/642 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   306 PLP-PQVQPARP---------------TTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAE 354
            |.| ||.||.:|               ||   .|.||:|........|..:..|.......:.:|
Human    83 PSPAPQAQPPKPVPKPRTVFGGLSGPATT---QRPGLSPALGGPGVSRSPEPSPRPPPLPTSSSE 144

  Fly   355 QKLWSLQAASSSTINENNNITKYNPGAANSLQ-GDCSQVQLRDPRDLAPPPGK-ELPTPTSTPTT 417
            |         ||.:    |..:..|   ||:. |..|:.:.:..:|.||...: ..|||...|||
Human   145 Q---------SSAL----NTVEMMP---NSIYFGLDSRGRAQAAQDKAPDSSQISAPTPALRPTT 193

  Fly   418 -----------------------------------------------SRKSRRRSNLFIPSSSK- 434
                                                           :|:....::|.:|..|. 
Human   194 GTVHIMDPGCLYYGVQPVGTPGAPDRRESRGVCQGRAEHRLSRQDLEAREDAGYASLELPGDSTL 258

  Fly   435 -KADKEKEPKSSELGS---------GRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGR-LTYH 488
             ....|.|..|.:|.|         .|..|:..|:|.|.|.:. |..:::::|..  :|| |.|.
Human   259 LSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQG-NYVFQRRFVQF--NGRSLMYF 320

  Fly   489 PSLHD-YMDDVHGKEIPLQYVTVKVPGQKPRGSK----SIITNSALTSSLMANGQ-----RAQNT 543
            .|..| :...|    |||..:      :..|.||    .:||           ||     |.::.
Human   321 GSDKDPFPKGV----IPLTAI------EMTRSSKDNKFQVIT-----------GQRVFVFRTESE 364

  Fly   544 LSDGIGCLTLAK--DNQRKLSE-------------KLSLLG--AGSIAAGAGGEPLKSNSSQQTS 591
            ....:.|.||..  ..||.|..             .|.|.|  |...||.:.||.....|.|..|
Human   365 AQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFS 429

  Fly   592 GDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLD 656
            ...||..                   :|.|..:|    |..||.|              :.:...
Human   430 LGIGICF-------------------IELQGCSV----RETKSRS--------------FDLLTP 457

  Fly   657 SKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCG 721
            .:.:.|.|.:...|..|.||:::.:.::|...|       .:..:.:..|.||       |.|||
Human   458 HRCFSFTAESGGARQSWAAALQEAVTETLSDYE-------VAEKIWSNRANRQ-------CADCG 508

  Fly   722 APNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDD--WPSPHLSVMLAIGNSLANSVWES 784
            :..|:||::||||::|.:|:|.||.|||.||||:||.||.  |.:..:.:.:.:||..||..|..
Human   509 SSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAG 573

  Fly   785 NTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRA 841
            ..     |..:....|.....|.::.::::  .||.....||......||::|:..|
Human   574 TL-----PPGEGLHPDATPGPRGEFISRKY--RLGLFRKPHPQYPDHSQLLQALCAA 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenG1ANP_723849.1 SelP_N <5..41 CDD:282453
Centaurin_gamma 143..300 CDD:133303
RAS 144..295 CDD:214541
PH_AGAP 451..686 CDD:241281 58/262 (22%)
PH 454..>521 CDD:278594 18/68 (26%)
ArfGap 702..818 CDD:279720 39/117 (33%)
ANK <834..907 CDD:238125 3/8 (38%)
ANK repeat 834..866 CDD:293786 3/8 (38%)
Ank_5 859..907 CDD:290568
ANK repeat 868..897 CDD:293786
ARAP3NP_071926.4 SAM_Arap1,2,3 4..66 CDD:188889
SAM 12..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..147 17/75 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..194 8/26 (31%)
PH 288..379 CDD:278594 28/114 (25%)
PH1_ARAP 289..381 CDD:270073 27/115 (23%)
PH2_ARAP 398..479 CDD:270074 26/117 (22%)
PH 399..482 CDD:278594 26/119 (22%)
ArfGap 490..606 CDD:279720 42/136 (31%)
PH3_ARAP 676..786 CDD:270076
PH-like <846..894 CDD:302622
RhoGAP_ARAP 909..1084 CDD:239850
RA 1117..1209 CDD:279168
PH5_ARAP 1212..1331 CDD:270079
PH 1241..1325 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1422..1544
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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