DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGAP9

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001177739.1	Gene:	AGAP9 / 642517	HGNCID:	23463	Length:	658	Species:	Homo sapiens

Alignment Length:	812	Identity:	261/812 - (32%)
Similarity:	360/812 - (44%)	Gaps:	199/812 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QRFESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSL 151
            |:..||.||...|||......||.|.:|.:::...|.:|
Human    19 QQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVE-------------------------- 57

  Fly   152 NSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFS 216
             .|:...:|:     ....|.||...|.            |..:...:...|.....||:.|..|
Human    58 -VGEDLHMHQ-----VRDREMPEALEFN------------LSANPEASTIFQRNSQTDALEFNSS 104

  Fly   217 LENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYET 281
            ...|.|  |::.        ||.|         .|.:..|.....:.....:.:..      |.:
Human   105 ANPEAS--TIFQ--------RNSQ---------TDVVEIRRSNCTNHVSTERFSQQ------YSS 144

  Fly   282 CATYGLNVERVFQD-ACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLR 345
            |:|..|:.....|. ....|:|..|.:|..:     |....:|               ...:|..
Human   145 CSTIFLDDSTAIQHYLTMTIISVTLEIPHHI-----TQRDADR---------------SLSIPDE 189

  Fly   346 MSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPT 410
            ....||.:...:...:....|..|.:::|    |...::.|        .||: .:.||....||
Human   190 QLHSFAVSTVHIMKKRNGGGSLNNYSSSI----PPTPSTSQ--------EDPQ-FSVPPTANTPT 241

  Fly   411 PTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSE-----LGSGRSIPIKQGYLYKRSSKSLNK 470
            |     ..::|.|.||||  :|.|.:|.:||.|:.|     :||||:||||||.|.|||.|.| |
Human   242 P-----VCKRSMRWSNLF--TSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298

  Fly   471 EWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNS-ALTSSLM 534
            .|||||||||.:|.|||:.||.|||.::|.|||.|:..|:||||:.|    |:.|:: |..||..
Human   299 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWP----SLATSACAPISSSK 359

  Fly   535 ANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMS 599
            :||               |:||.                                   |.|:
Human   360 SNG---------------LSKDM-----------------------------------DTGL--- 371

  Fly   600 NSNSQTFIAGEVANAGNKLE-AQTPNV-KKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHF 662
             .:|..|..|..:....||. ..:|:. ||:|.:.||::            .|.|||...:.|||
Human   372 -GDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTN------------NFMIVSATGQTWHF 423

  Fly   663 EAANSEERDEWVAAVEQEIFKSLQSIESSKTK-QATSTDLAAMLAIRQRVPGNGFCVDCGAPNPE 726
            ||...||||.||.|::.:|..||||.:|||:| |.||...|..|...|.:.||..||||...||:
Human   424 EATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPK 488

  Fly   727 WASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVK 791
            ||||||||||||||||:||:.|:.:|:||||.|||||.....||.:|||.||||:||.:::.:.|
Human   489 WASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQTK 553

  Fly   792 PTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSP--SPGQQLIEAVIRADIKSIVSILANCP 854
            |:.:::||:||.|:|||||.|.||.||       |..  |.||||:.|....|:::.:.:||:..
Human   554 PSIKSTREEKEWWIRSKYEEKLFLAPL-------PCTELSLGQQLLRATTDEDLQTAILLLAHGS 611

  Fly   855 SEVTNANVSARDVRTPLLLACAIGNLAIAQLL 886
            .|..|......|..|.|.|||..||:.:.|||
Human   612 REEVNETCGEGDGCTALHLACRKGNVVLEQLL 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	25/157 (16%)
		RAS	144..295	CDD:214541	24/150 (16%)
		PH_AGAP	451..686	CDD:241281	84/237 (35%)
		PH	454..>521	CDD:278594	41/66 (62%)
		ArfGap	702..818	CDD:279720	66/115 (57%)
		ANK	<834..907	CDD:238125	18/53 (34%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	12/28 (43%)
		ANK repeat	868..897	CDD:293786	10/19 (53%)
AGAP9	NP_001177739.1	PH_AGAP	280..444	CDD:241281	83/234 (35%)
		PH	283..442	CDD:278594	80/229 (35%)
		ArfGap	466..580	CDD:279720	65/113 (58%)
		ANK repeat	591..621	CDD:293786	7/29 (24%)
		Ank_2	<596..643	CDD:289560	14/46 (30%)
		Ank	623..>643	CDD:278452	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4206
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820