DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and arfgap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_005159305.1	Gene:	arfgap2 / 641490	ZFINID:	ZDB-GENE-051120-177	Length:	551	Species:	Danio rerio

Alignment Length:	288	Identity:	65/288 - (22%)
Similarity:	104/288 - (36%)	Gaps:	96/288 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 QATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGL 759
            :...|::..:....:.:|.|..|.||.|.||.|||::.||.:||:|||:||:||.|:|.:||..|
Zfish     4 EPNKTEIHTIFKRLRSIPTNKACFDCAAKNPSWASISYGVFLCIDCSGIHRSLGVHLSFIRSTEL 68

  Fly   760 D-DWPSPHLSVMLAIGNSLA--------------NSVWESNT----RQRVKPTSQA--SREDKER 803
            | :|....|..|...||:.|              |:.:.|..    |::::..:.|  |:...:.
Zfish    69 DSNWNWFQLRCMQVGGNANAMGFFRQHGCTTNDTNAKYNSRAAQMYREKIRQLANAALSKYGTDL 133

  Fly   804 WVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVR 868
            |:.|             .|.|.|||                            |........|..
Zfish   134 WIDS-------------SSCAQPSP----------------------------VEKRETDFFDEH 157

  Fly   869 TPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAA------AQA 927
            |...::             |:.|:...||..|               |:::....|      ::.
Zfish   158 TQPAIS-------------WDMASPSLTDQNG---------------AENVNPQLAQSNPKNSET 194

  Fly   928 GTTIPAPAPPTNGGIPAPQYNVEDTTAL 955
            ..|.|...|...|...:|:..:||:..|
Zfish   195 PNTQPEEGPSIEGLSTSPKATIEDSMRL 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	41/136 (30%)
		ANK	<834..907	CDD:238125	8/72 (11%)
		ANK repeat	834..866	CDD:293786	1/31 (3%)
		Ank_5	859..907	CDD:290568	7/47 (15%)
		ANK repeat	868..897	CDD:293786	3/28 (11%)
arfgap2	XP_005159305.1	PLN03114	1..498	CDD:178661	65/288 (23%)
		ArfGap	13..117	CDD:279720	37/103 (36%)
		TMF_DNA_bd	270..331	CDD:289127
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900