DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and SMAP1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001037770.1	Gene:	SMAP1 / 60682	HGNCID:	19651	Length:	467	Species:	Homo sapiens

Alignment Length:	309	Identity:	85/309 - (27%)
Similarity:	124/309 - (40%)	Gaps:	81/309 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   710 RVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIG 774
            |...|.:|.||.|..|.|||.|:||.:||.|:|:|||||.|||:|:|:.||.|.:..:..|..:|
Human    26 REEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDMG 90

  Fly   775 NSLANSVWESNTRQ--RVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEA 837
            |:.|..::|:|..:  |...|.||    .|.::|.|||.|::..
Human    91 NTKARLLYEANLPENFRRPQTDQA----VEFFIRDKYEKKKYYD--------------------- 130

  Fly   838 VIRADIKSIVSILANCPSEVTNANVSARD------VRTPLLLACAIGNLAIAQLLIWNGANIKHT 896
                  |:.::|          .|:|:.|      |.:|.|.|....|....:       ..|..
Human   131 ------KNAIAI----------TNISSSDAPLQPLVSSPSLQAAVDKNKLEKE-------KEKKK 172

  Fly   897 DHEGR-----------TCLAYARAAQSLATAKSIKAAAAAQ-----AGTTIPAPAPPTNGGIPAP 945
            :.:.|           |.....:..|.|...||.....||:     .|...||.||.|||....|
Human   173 EEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVP 237

  Fly   946 QYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTPYEKSVSGV 994
            ..|.:        |:..|...:.||.|: .:|..:.|...|...::|.|
Human   238 PLNDD--------LDIFGPMISNPLPAT-VMPPAQGTPSAPAAATLSTV 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	46/109 (42%)
		ANK	<834..907	CDD:238125	13/89 (15%)
		ANK repeat	834..866	CDD:293786	4/31 (13%)
		Ank_5	859..907	CDD:290568	11/64 (17%)
		ANK repeat	868..897	CDD:293786	5/28 (18%)
SMAP1	NP_001037770.1	ArfGap	20..120	CDD:279720	41/97 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..224		15/85 (18%)
		Interaction with clathrin heavy chains. /evidence=ECO:0000250	218..222		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810