DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and agap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_009295321.1	Gene:	agap2 / 565109	ZFINID:	ZDB-GENE-061103-343	Length:	1130	Species:	Danio rerio

Alignment Length:	859	Identity:	323/859 - (37%)
Similarity:	462/859 - (53%)	Gaps:	135/859 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 EDSFVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSY 189
            |.|..||||||::|::|:||||::||:.|||||||:|::||||:..||.||||:||||.::|||.
Zfish   337 EASCANSQEWTLTRTIPELRLGVLGSIRSGKSALVNRFITGSYLPLESHEGGRYKKEVLVEGQSQ 401

  Fly   190 LLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAIS 254
            |||||:|.|.|..|...|:|.:|.|||||||.||..||..|::::..||..|||:|.|||||.||
Zfish   402 LLLIREESGPPSAQLCNWLDGLILVFSLENEASFQEVYKNYSELSAHRNIAEIPIIAVGTQDKIS 466

  Fly   255 ERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQR-----------LPLP 308
            ..|.|||:|.|.::|..|::||:||||||||||||:|||.:..|||::.:           ||..
Zfish   467 STNARVIEDKRVQQLCIDVRRCTYYETCATYGLNVDRVFNEMTQKIVAAKKQAALLASCKSLPNS 531

  Fly   309 PQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTIN---E 370
            |....|.           .|...|.....|.|      |:|:..:   |.|....|...|.   .
Zfish   532 PSHSGAS-----------TPVSGPGQASNGAQ------SSDYPSS---LPSTPVISHKDIRGGAS 576

  Fly   371 NNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKK 435
            .:.:|:.||                                         .|||::||  ::.:.
Zfish   577 GDGVTQRNP-----------------------------------------PRRRTSLF--ANRRG 598

  Fly   436 ADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHG 500
            :|.||....|...:.||:|||||.|:|||.:|||||||||||||.:.|.||||.::::::.:..|
Zfish   599 SDSEKRSSDSRSDTSRSVPIKQGTLWKRSERSLNKEWKKKYVTLSNSGMLTYHSNINEFLQNAQG 663

  Fly   501 KEIPLQYVTVKVPGQK---------PRGSKSII----TNSALTSSLMANGQRAQNTLS-DGIGCL 551
            ||:.|..|||||||::         |....:::    .|..........|..|.|.|: :.....
Zfish   664 KEMDLLRVTVKVPGKRLHRAAAPGAPSPGPALVPVPGVNGLSKDKQTPEGGAASNLLTVEEASRA 728

  Fly   552 TLAKDNQRKLSEKLSLL-----GAGSIAAGAGGEPLKSN---SSQQTSGDEGIAMSNSNSQTFIA 608
            .|:..|.:|:....|.:     ...|...||...||...   ||..|...:    ...|....:.
Zfish   729 GLSYPNDQKVKRCPSSVSNKGFSVDSSIEGATSPPLGKEHMPSSPMTDRKK----KKRNRSINLK 789

  Fly   609 GEVANAGNKLEAQTPNVKKRHRRMKS-SSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDE 672
            |:.|       |.....|::..::|| .|::.....:.:..:|.|:|...:.|||||.:.|:||.
Zfish   790 GDAA-------AGQAEAKRKMWKLKSFGSLRNINKTEEESVDFIIISSTGQSWHFEAQSQEDRDA 847

  Fly   673 WVAAVEQEIFKSLQSIES-SKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLM 736
            ||.|:|.:|..||||.|| :|.::.:.::..|:.||| ...||..||||.||||.|||||||.|:
Zfish   848 WVQAIESQILASLQSCESRNKARRNSQSEAVALQAIR-NAKGNDLCVDCAAPNPTWASLNLGALI 911

  Fly   737 CIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDK 801
            ||||||:|||||:|:|:||||.||.|||....|:.||||.:||.:||:.|:...|.|.:|:||.:
Zfish   912 CIECSGIHRNLGTHLSRVRSLDLDVWPSELTKVLSAIGNHMANHIWETCTQGCQKLTPEATREQR 976

  Fly   802 ERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQ--------QLIEAVIRADIKSIVSILANCPSEVT 858
            |.|:|:|||.:.|::||           |.|        .|::|||..|:.:::.:||:...|:.
Zfish   977 ESWIRAKYEQRAFVSPL-----------PAQCSEDTMSTWLLKAVINRDLPNLLLLLAHSTKELI 1030

  Fly   859 N--ANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAK-SIK 920
            |  ...:.:...:.|..||.:|::.:.|||:|.|:::|..|.:|||.|..||.|.|...|: .::
Zfish  1031 NIPPEGAGQQHHSALHAACQLGDVVMTQLLVWYGSDVKSKDPQGRTALTLARQAGSKECAEILVQ 1095

  Fly   921 AAAAAQAGTTIPAP 934
            ....::...|.|.|
Zfish  1096 HGCPSETSPTSPTP 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	94/156 (60%)
		RAS	144..295	CDD:214541	92/150 (61%)
		PH_AGAP	451..686	CDD:241281	83/257 (32%)
		PH	454..>521	CDD:278594	39/75 (52%)
		ArfGap	702..818	CDD:279720	66/115 (57%)
		ANK	<834..907	CDD:238125	24/74 (32%)
		ANK repeat	834..866	CDD:293786	9/33 (27%)
		Ank_5	859..907	CDD:290568	16/49 (33%)
		ANK repeat	868..897	CDD:293786	10/28 (36%)
agap2	XP_009295321.1	Centaurin_gamma	355..512	CDD:133303	94/156 (60%)
		Ras	359..512	CDD:278499	90/152 (59%)
		PH-like	616..861	CDD:302622	81/255 (32%)
		ArfGap	879..993	CDD:279720	66/114 (58%)
		ANK repeat	1040..1071	CDD:293786	10/30 (33%)
		Ank_4	1041..1094	CDD:290365	20/52 (38%)
		ANK	1042..>1098	CDD:238125	20/55 (36%)
		ANK repeat	1073..1098	CDD:293786	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	735	1.000	Inparanoid score	I591
OMA	1	1.010	-	-		QHG48005
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	1	1.000	-	-		otm25067
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980