DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and acap2a

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_005163306.1	Gene:	acap2a / 564814	ZFINID:	ZDB-GENE-081104-34	Length:	824	Species:	Danio rerio

Alignment Length:	884	Identity:	191/884 - (21%)
Similarity:	303/884 - (34%)	Gaps:	312/884 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 GWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNG-----------QEIPMILVGTQDAISERN-- 257
            |.:||             ..|||...|  .|.||           :.|...|....:.:.|.|
Zfish    44 GMIDA-------------GRVYNQANK--QFVNGIRDLALQSTRDEVIGSSLAAFSETLQEMNNY 93

  Fly   258 PRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDA---CQKILSQRLPLPPQVQPARPTTP 319
            ..::.|...|.:.|.|:         |:.....|.|:||   ..|:..::       :.|.....
Zfish    94 HTILFDQAQRSIRSQLQ---------TFVKEDLRKFKDAKKQFDKVSEEK-------EVALVKNA 142

  Fly   320 QGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWS---LQAASSSTINENNNITKYNPGA 381
            |..|..|...:..||.....|:....::.|:......|.|   |:...|.....|.|:|.:|.|
Zfish   143 QVPRNKLHEVEEATNILTTTQKFFRNIALDYVLQINVLQSKRRLEILKSMLAYMNANLTFFNQG- 206

  Fly   382 ANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSE 446
             :.|   .||:|                     |...:.|.:...|.:.|:.:|.|.|::..|.:
Zfish   207 -HDL---FSQLQ---------------------PLMKQLSGQLDQLVVDSAKEKRDMEQKHSSIQ 246

  Fly   447 ------------------LGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHD 493
                              :.:...|.: :|||:||:|.:. |.|.:::.:: .:.:|.|.....|
Zfish   247 QKAALQDFSTEDSKLEYNIDTDNGIAM-EGYLFKRASNAF-KTWNRRWFSI-QNSQLVYQKRFRD 308

  Fly   494 ----YMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLA 554
                .::|       |:..|||                                     .|
Zfish   309 NPTVVVED-------LRLCTVK-------------------------------------HC---- 325

  Fly   555 KDNQRKLS-EKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKL 618
            :|.:|:.. |.||              |.||            .|..::|:
Zfish   326 EDVERRFCFEVLS--------------PSKS------------CMMQADSE-------------- 350

  Fly   619 EAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFK 683
                        :::.:.:||.::.....|.                  |..|| :.:::::...
Zfish   351 ------------KLRQAWIKAVQSSIASAYR------------------ENEDE-IISLDRQSSA 384

  Fly   684 SLQSI----ESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVH 744
            ||.|:    ||.|..:..|. |..:|||    |||.||.|||..:|.|||:||.:.:||||||:|
Zfish   385 SLGSLDSGCESVKLVKGESA-LQRVLAI----PGNEFCCDCGQSDPRWASINLCITLCIECSGIH 444

  Fly   745 RNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQR--VKPTSQASREDKERWVRS 807
            |:||.|.||||||.||.|....|.:|..:||.:.|.::|::..:.  .||.....|.:.|.::|:
Zfish   445 RSLGVHNSKVRSLTLDTWEPELLKLMCELGNDVINQIYEAHREENGGKKPQPGDPRREIEAFIRA 509

  Fly   808 KYEAKEF-LTPL-------------------GNGSSAHPSPSPGQQLIEAVIRADIKSIV----- 847
            ||..|.| |.|.                   ||.....|.|.|....:.....|.:.|:.
Zfish   510 KYVDKRFVLKPTEQEQMEKIMTLRKHDKRMQGNMEFLPPRPPPPTPKLRTASNASVASLSGQEVR 574

  Fly   848 --SILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAA 910
              |:.  ||.|: ::..|..|..:.|      .||..|...|.|.|:      ..|..||...::
Zfish   575 RDSLF--CPDEL-DSLFSYFDTSSKL------QNLKRADSGIQNSAD------GSREMLASTPSS 624

  Fly   911 QSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQY------------------------NVED 951
            .||:.....::.|||......|..:..||....:..|                        |:||
Zfish   625 SSLSETDLPESEAAANQAERSPVFSKLTNFSADSLLYWASCACSLKDMAQALAHGADINWVNLED 689

  Fly   952 T--TALVE------------LLEGLGCPEAAPLTASGTL 976
            :  |.|::            ||:...|.:...:...|.|
Zfish   690 SSRTPLIQAVQGGSLISCEFLLQNAACVDQQDIRGRGPL 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	23/109 (21%)
		RAS	144..295	CDD:214541	21/101 (21%)
		PH_AGAP	451..686	CDD:241281	35/239 (15%)
		PH	454..>521	CDD:278594	16/70 (23%)
		ArfGap	702..818	CDD:279720	53/118 (45%)
		ANK	<834..907	CDD:238125	18/79 (23%)
		ANK repeat	834..866	CDD:293786	7/38 (18%)
		Ank_5	859..907	CDD:290568	12/47 (26%)
		ANK repeat	868..897	CDD:293786	7/28 (25%)
acap2a	XP_005163306.1	BAR_ACAP2	18..217	CDD:153322	46/229 (20%)
		PH_ACAP	273..369	CDD:270070	29/198 (15%)
		PH	273..365	CDD:278594	29/194 (15%)
		ArfGap	402..520	CDD:279720	55/122 (45%)
		ANK repeat	657..686	CDD:293786	1/28 (4%)
		ANK	658..776	CDD:238125	11/71 (15%)
		Ank_2	660..754	CDD:289560	11/69 (16%)
		ANK repeat	690..721	CDD:293786	5/30 (17%)
		ANK repeat	723..754	CDD:293786	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820