DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and ADAP2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_024306599.1	Gene:	ADAP2 / 55803	HGNCID:	16487	Length:	403	Species:	Homo sapiens

Alignment Length:	113	Identity:	45/113 - (39%)
Similarity:	64/113 - (56%)	Gaps:	12/113 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   710 RVP--GNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLA 772
            |.|  ||..|.||||.:|:|||..||:.:|:.|.|||||. ..||:|:|:.||.|....:..|:.
Human    16 RAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79

  Fly   773 IGNSLANSVWESNTRQRVK-----PTSQASREDKERWVRSKYEAKEFL 815
            .||....:.:|:    ||.     |.:......||:|:|:|||.:||:
Human    80 NGNLRVKAKFEA----RVPAFYYIPQANDCLVLKEQWIRAKYERREFM 123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	45/113 (40%)
		ANK	<834..907	CDD:238125
		ANK repeat	834..866	CDD:293786
		Ank_5	859..907	CDD:290568
		ANK repeat	868..897	CDD:293786
ADAP2	XP_024306599.1	ArfGap	8..126	CDD:307528	45/113 (40%)
		PH1_ADAP	133..241	CDD:270072
		PH2_ADAP	255..362	CDD:241282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900