DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and smap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001038260.1	Gene:	smap2 / 556132	ZFINID:	ZDB-GENE-060503-374	Length:	418	Species:	Danio rerio

Alignment Length:	365	Identity:	91/365 - (24%)
Similarity:	151/365 - (41%)	Gaps:	83/365 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 QSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSH 750
            :|::.....||.   |.::|.:.:    |.||.||.|..|.|||.|||:.:||.|:|:|||||.|
Zfish     4 RSVKDIDRYQAV---LTSLLTLEE----NKFCADCYAKGPRWASWNLGIFICIRCAGIHRNLGVH 61

  Fly   751 ISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWES---NTRQRVKPTSQASREDKERWVRSKYEAK 812
            ||:|:|:.||.|....:..:..:||:.|..::|:   ...||.: |.||:    |.::|.||:.|
Zfish    62 ISRVKSVNLDQWTQEQIQSVQEMGNAKARRLYEAFLPECFQRPE-TDQAA----EIFIRDKYDKK 121

  Fly   813 EFL----------------------------------------TPLGNGSSAHP-------SPSP 830
            :::                                        ||.....|.:.       :|.|
Zfish   122 KYMDKCIDIQSFRKEKSETVTKEAPVVFEKMKLKKDESQQFKSTPKKQSQSVNDLLGLDALAPQP 186

  Fly   831 GQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIA---QLLIWNGAN 892
              .:......|:|...:.:.::.|:.|:|:| |||.  ||...:...|.:|.:   .|.::....
Zfish   187 --PVTNGKPSAEISPALDLFSSLPAAVSNSN-SARS--TPSSGSMPTGRVAASVPENLSLFLDPP 246

  Fly   893 IKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVE 957
            .|..|...:..   ..:..||.::.:.:...||.||..:.|   ...|.:||..|.....   :.
Zfish   247 TKSEDSGKKLS---KDSILSLYSSTAPQTNMAAHAGMYMGA---TQMGYVPAAGYGQYQA---LG 302

  Fly   958 LLEGLGCPEAAP----LTASGTLPRRRDTLGTPYEKSVSG 993
            ..:|:..|..||    :..:|.:|:.......||...|.|
Zfish   303 AQQGMMGPMMAPHMNIVGQAGVMPQTGAAAAPPYMAGVQG 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	91/365 (25%)
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	46/158 (29%)
		ANK	<834..907	CDD:238125	16/75 (21%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		Ank_5	859..907	CDD:290568	12/50 (24%)
		ANK repeat	868..897	CDD:293786	6/31 (19%)
smap2	NP_001038260.1	COG5347	13..>275	CDD:227651	71/281 (25%)
smap2	NP_001038260.1	ArfGap	13..115	CDD:279720	44/113 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810