DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and APPL2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001238833.1	Gene:	APPL2 / 55198	HGNCID:	18242	Length:	670	Species:	Homo sapiens

Alignment Length:	270	Identity:	49/270 - (18%)
Similarity:	91/270 - (33%)	Gaps:	86/270 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   632 MKSSSVKANEADDNDGYEFYIVSLDSKQW-HFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQ 695
            :.:.||.|.:.:|. .|.|.|.:.:.|.. ..:|.:.:|.:||:.|:            ::.::|
Human   331 LDNCSVMAVDCEDR-RYCFQITTPNGKSGIILQAESRKENEEWICAI------------NNISRQ 382

  Fly   696 ATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGL- 759
            ...||                       |||..::.|           ::.....::.:.|.|.
Human   383 IYLTD-----------------------NPEAVAIKL-----------NQTALQAVTPITSFGKK 413

  Fly   760 --DDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRS----KYE----AKEF 814
              ...||          .:|.||..| |...::.|.:.||..:.|..:..    :::    |.||
Human   414 QESSCPS----------QNLKNSEME-NENDKIVPKATASLPEAEELIAPGTPIQFDIVLPATEF 467

  Fly   815 L---------TPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTP 870
            |         .|.|. :.....|.....|::.:.      ||..|.:...:..:......:....
Human   468 LDQNRGSRRTNPFGE-TEDESFPEAEDSLLQQMF------IVRFLGSMAVKTDSTTEVIYEAMRQ 525

  Fly   871 LLLACAIGNL 880
            :|.|.||.|:
Human   526 VLAARAIHNI 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	13/54 (24%)
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	21/135 (16%)
		ANK	<834..907	CDD:238125	9/47 (19%)
		ANK repeat	834..866	CDD:293786	4/31 (13%)
		Ank_5	859..907	CDD:290568	5/22 (23%)
		ANK repeat	868..897	CDD:293786	5/13 (38%)
APPL2	NP_001238833.1	BAR_APPL2	20..240	CDD:153316
		BAR-PH_APPL	258..382	CDD:270067	13/63 (21%)
		PTB_APPL	488..621	CDD:269980	10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810