DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenG1A and ASAP1

DIOPT Version :9

Sequence 1:NP_723849.1 Gene:CenG1A / 34803 FlyBaseID:FBgn0028509 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_001349853.1 Gene:ASAP1 / 50807 HGNCID:2720 Length:1132 Species:Homo sapiens


Alignment Length:581 Identity:135/581 - (23%)
Similarity:236/581 - (40%) Gaps:104/581 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   360 LQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTP-TSTPTTSRKSRR 423
            ||..|.:.|...:::.|   |....::||     |:.|.|.|   .|:..|. |......|:..:
Human   136 LQGLSHNVIFTLDSLLK---GDLKGVKGD-----LKKPFDKA---WKDYETKFTKIEKEKREHAK 189

  Fly   424 RSNLF---IPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRL 485
            :..:.   |..:....:.|||.:..:|....       ||.|     :|:...||.|.|..:...
Human   190 QHGMIRTEITGAEIAEEMEKERRLFQLQMCE-------YLIK-----VNEIKTKKGVDLLQNLIK 242

  Fly   486 TYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQNTLSDGIGC 550
            .||...:.:.|.:...:...||:                      ..|.|:....:.|..:....
Human   243 YYHAQCNFFQDGLKTADKLKQYI----------------------EKLAADLYNIKQTQDEEKKQ 285

  Fly   551 LTLAKD---NQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFI----A 608
            ||..:|   :..:|.:|.|...:.|...|.....|:.| .:..|..:|..:..|:....:    .
Human   286 LTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGN-KEYGSEKKGYLLKKSDGIRKVWQRRK 349

  Fly   609 GEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEW 673
            ..|.|....:...|.|.:.....:.:..||.| |:|...::  ::| .::.:||:|.:.::...|
Human   350 CSVKNGILTISHATSNRQPAKLNLLTCQVKPN-AEDKKSFD--LIS-HNRTYHFQAEDEQDYVAW 410

  Fly   674 VAAV----EQEI---FKSLQSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLN 731
            ::.:    |:.:   |:..||...:..:..|.    |::...||:|||..|.|||:..|.|.|.|
Human   411 ISVLTNSKEEALTMAFRGEQSAGENSLEDLTK----AIIEDVQRLPGNDICCDCGSSEPTWLSTN 471

  Fly   732 LGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESN-TRQRVKPTSQ 795
            ||:|.||||||:||.:|.|||:::||.||...:..|.:...:||:..|.:.|:| .....|||..
Human   472 LGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPS 536

  Fly   796 ASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNA 860
            :....::.::.:||....|.....:.|||..:     :|:||:...|:.:::.:.|         
Human   537 SDMTVRKEYITAKYVDHRFSRKTCSTSSAKLN-----ELLEAIKSRDLLALIQVYA--------- 587

  Fly   861 NVSARDVRTPLL----------LACAI-----GNLAIAQLLIWNGANIKHTDHEGRTCLAY 906
              ...::..|||          |..|:     .:|.:...|:.|..|:......|.|.|.|
Human   588 --EGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHY 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenG1ANP_723849.1 SelP_N <5..41 CDD:282453
Centaurin_gamma 143..300 CDD:133303
RAS 144..295 CDD:214541
PH_AGAP 451..686 CDD:241281 45/248 (18%)
PH 454..>521 CDD:278594 13/66 (20%)
ArfGap 702..818 CDD:279720 45/116 (39%)
ANK <834..907 CDD:238125 18/88 (20%)
ANK repeat 834..866 CDD:293786 5/31 (16%)
Ank_5 859..907 CDD:290568 13/63 (21%)
ANK repeat 868..897 CDD:293786 9/43 (21%)
ASAP1NP_001349853.1 BAR_ASAP1 54..268 CDD:153325 34/176 (19%)
PH_ASAP 319..425 CDD:270071 20/110 (18%)
ArfGap 442..558 CDD:307528 45/119 (38%)
ANK 1 603..635 6/31 (19%)
ANK <604..692 CDD:238125 10/43 (23%)
ANK repeat 604..637 CDD:293786 6/32 (19%)
ANK repeat 639..670 CDD:293786 4/8 (50%)
ANK 2 639..668 4/8 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..763
Atrophin-1 <727..1063 CDD:331285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..1065
SH3_ASAP1 1074..1130 CDD:212898
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D751525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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