DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and Arhgap42

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_576354.3	Gene:	Arhgap42 / 500943	RGDID:	1564081	Length:	875	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	173/966 - (17%)
Similarity:	301/966 - (31%)	Gaps:	378/966 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SLAIR---QEIQRFESVHPSIYAIYELIDLLPMADAQ------IAQSIRDH---VVCIEDS---F 128
            |:|::   |.:|.|:         :|.|     .||:      ||||:::.   ::.:|:.   .
  Rat    54 SMAVQKFSQSLQDFQ---------FECI-----GDAETDDEISIAQSLKEFARLLIAVEEERRRL 104

  Fly   129 VNSQEWTISRSVPDLRLGIVGSLNSGKS----------ALVHRYLT------GSYMQEESPEGGR 177
            :.:....:...:...|...:|:...||.          :::.::|.      .|::||...:.||
  Rat   105 IQNANDVLIAPLEKFRKEQIGAAKDGKKKFDKESEKYYSILDKHLNLSAKKKESHLQEADSQIGR 169

  Fly   178 FKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIF----VFSLENEGSFNTVYNYYTKMAHFRN 238
            ..:..:.....|:..|::.....:.:|   |:.::.    :|:..:||     |....:.|.::
  Rat   170 EHQNFYEASLEYVFKIQEVQEKKKFEF---VEPLLSFLQGLFTFYHEG-----YELAQEFAPYK- 225

  Fly   239 GQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQ 303
             |::...|..|::.        .:.||.                     .|||:.|.  .|..:|
  Rat   226 -QQLQFNLQNTRNN--------FESTRQ---------------------EVERLMQR--MKAANQ 258

  Fly   304 RLPLPPQ--------VQPARP----------TTPQGNR---LGLAPYQA--PTNG---------- 335
            ....|.|        ||..||          |..:|::   :.::..:|  ..||
  Rat   259 DYRPPSQWTMEGYLYVQEKRPLGFTWTKHYCTYDKGSKMFTMSVSDVKASGKMNGLVTGSPEMFK 323

  Fly   336 -----QRGQQQLPLRMSAD--------------FAQAEQKLW-----------SLQAASSST--- 367
                 :|....:..|...|              |::|.:|||           :|.|..|..
  Rat   324 LKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEANRKLWLEAMDGKEPIYTLPAIISKKEEM 388

  Fly   368 -INEN-----------------NNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTST 414
             :||.                 |.:..|..|..|      |:||
  Rat   389 YLNEAGFNFVRKCIQAVETRGINILGLYRIGGVN------SKVQ--------------------- 426

  Fly   415 PTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTL 479
                   :..:..|.|.|....|.:     .||...::|           :..|     |.|:..
  Rat   427 -------KLMNTTFSPKSPPDMDID-----IELWDNKTI-----------TSGL-----KNYLRC 463

  Fly   480 CDDGRLTYHPSLH-DYM-----DDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQ 538
            ..:..:||  .|| |::     ||.:.:...:..:..|:| :|.|....|:....|..||.:.
  Rat   464 LAEPLMTY--KLHKDFIIAVKSDDQNYRVEAVHALVHKLP-EKNREMLDILIKHLLKVSLHSQ-- 523

  Fly   539 RAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNS 603
              ||.::                   :|.||   :..|    |....:.::|..    ||.|...
  Rat   524 --QNLMT-------------------ISNLG---VIFG----PTLMRAQEETVA----AMMNIKF 556

  Fly   604 QTFIAGEVANAGNKL--EAQTPNVKKRHRRMKSSSVKAN-------------------EADDNDG 647
            |..:...:.....|:  .|..||:.....:.:|.|.:..                   ...|:|.
  Rat   557 QNIVVEILIEHYEKIFHTAPDPNIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDS 621

  Fly   648 YEFY-----IVSLDSKQWHFEAANS-------EERDE-----WVAAVEQEI-FKSL----QSIES 690
            |...     :.|::|...|....||       :.|::     |:||..... .|||    .|.||
  Rat   622 YSSSPDSTPMGSIESLSSHSSEQNSTTKSTSCQPREKSGGIPWIAAPSSSNGQKSLGLWTTSPES 686

  Fly   691 SKTKQATSTDLAAMLAIRQRVPGNGFCVDC---------GAPNPEWASLNLG------------- 733
            |..:.||.||:.:               ||         |..:|....:..|
  Rat   687 SSREDATKTDVES---------------DCQSVASVTSPGDVSPPIDLVKKGPYGLSGLKRSSAS 736

  Fly   734 -VLMCIECSGVHRNLGSHISKVRSLGLDD----WPSPHLSVMLAIGNSLANSVWESNTRQR---- 789
             .|..|..:..:::....|..:.|:|..:    .|:|.|...:.  ..|......||..||
  Rat   737 SSLRSISAAEGNKSYSGSIQSLTSIGSKESPKATPNPELPPKMC--RRLRLDTASSNGYQRPGSV 799

  Fly   790 -------------VKPTSQASREDKERWVRSKYEAKEFLTPLGN-GSSAHPSPSPG 831
                         :||.| :.|:.|..:......:.|...|.|. .|:.|||..||
  Rat   800 VAAKAQLFENAGSLKPVS-SGRQAKAMYSCKAEHSHELSFPQGAIFSNVHPSVEPG 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	28/176 (16%)
		RAS	144..295	CDD:214541	27/170 (16%)
		PH_AGAP	451..686	CDD:241281	52/283 (18%)
		PH	454..>521	CDD:278594	14/72 (19%)
		ArfGap	702..818	CDD:279720	24/159 (15%)
		ANK	<834..907	CDD:238125
		ANK repeat	834..866	CDD:293786
		Ank_5	859..907	CDD:290568
		ANK repeat	868..897	CDD:293786
Arhgap42	XP_576354.3	BAR_GAP10-like	19..225	CDD:153318	33/192 (17%)
		BAR-PH_GRAF_family	267..376	CDD:269953	17/108 (16%)
		PH	267..369	CDD:278594	17/101 (17%)
		RhoGAP	369..567	CDD:295372	49/289 (17%)
		SH3_GRAF3	821..875	CDD:212999	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910