Protein Alignment CenG1A and AGAP6

DIOPT Version :10

• Sequence 1: NP_723849.1
• Gene: CenG1A / 34803
• FlyBaseID: FBgn0028509
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: NP_001071133.2
• Gene: AGAP6 / 414189
• HGNCID: 23466
• Length: 686
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 264/737 - (35%)
• Similarity: 350/737 - (47%)
• Gaps: 151/737 - (20%)

  Fly   193 IRDEGGAPEMQF---AGWVDAVIFVFSLENEG-SFNTVYNYYTKMAHFRNGQEIPMILVGTQDAI 253
            :||......::|   |....:.||..:.:.|. .||...|........||.|         .|.:
Human    67 VRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQ---------TDVV 122

  Fly   254 SERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQD-ACQKILSQRLPLPPQVQPARPT 317
            ..|.....:...|.:.:..      |..|:|..|:.....|. ....|:|..|.:|..:     |
Human   123 EIRRSNCTNHVSAVRFSQQ------YSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHI-----T 176

  Fly   318 TPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAA 382
            ....:|....|          .:||     ..||.:...:...:....|..|.:::|    |...
Human   177 QRDADRTLSIP----------DEQL-----HSFAVSTVHIMKKRNGGGSLNNYSSSI----PSTP 222

  Fly   383 NSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSE- 446
            ::.|        .||: .:.||....|||     ..::|.|.||||  :|.|.:|.:||.|:.|
Human   223 STSQ--------EDPQ-FSVPPTANTPTP-----VCKRSMRWSNLF--TSEKGSDPDKERKAPEN 271

  Fly   447 ----LGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQY 507
                :||||:||||||.|.|||.|.| |.|||||||||.:|.|||:.||.|||.::|.|||.||.
Human   272 HADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQT 335

  Fly   508 VTVKVPGQKPRGSKSIITNSALT--SSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGA 570
            .|:||||:.|.     :..||.|  ||..:||               |:||
Human   336 STIKVPGKWPS-----LATSACTPISSSKSNG---------------LSKD-------------- 366

  Fly   571 GSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLE-AQTPNV-KKRHRRMK 633
              :..|.|               :.|..|.|.|.|        ...||. ..:|:. ||:|.:.|
Human   367 --MDTGLG---------------DSICFSPSISST--------TSPKLNPPPSPHANKKKHLKKK 406

  Fly   634 SSSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTK-QAT 697
            |::            .|.|||...:.|||||...||||.||.|::.:|..||||.||||:| |.|
Human   407 STN------------NFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLT 459

  Fly   698 STDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDW 762
            |...|..|...|.:.||..||||...||:||||||||||||||||:||:||.|:|:||||.||||
Human   460 SQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDW 524

  Fly   763 PSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPS 827
            |.....||.:|.|.||||:||.:::.:.||:.:::||:||||:|||||.|.||.||       |.
Human   525 PVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPL-------PC 582

  Fly   828 P--SPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNG 890
            .  |.||||:.|....|:::.:.:||:...|..|......|..|.|.|||..||:.:||||||.|
Human   583 TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647

  Fly   891 ANIKHTDHEGRTCLAYARAAQS 912
            .::...|..|.|.|.|||.|.|
Human   648 VDVMARDAHGNTALTYARQASS 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<2..41	CDD:461363
		Centaurin_gamma	143..300	CDD:133303	21/111 (19%)
		PH_AGAP	451..686	CDD:241281	87/238 (37%)
		ArfGap_AGAP	702..810	CDD:350065	63/107 (59%)
		ANKYR	<834..>907	CDD:440430	26/72 (36%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		ANK repeat	868..897	CDD:293786	14/28 (50%)
AGAP6	NP_001071133.2	PH_AGAP	280..447	CDD:241281	87/238 (37%)
		ArfGap	464..572	CDD:355783	63/107 (59%)
		ANKYR	<591..>680	CDD:440430	31/79 (39%)
		ANK repeat	591..621	CDD:293786	7/29 (24%)
		ANK repeat	623..654	CDD:293786	15/30 (50%)
		ANK repeat	656..681	CDD:293786	8/14 (57%)