DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGAP6

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001071133.2	Gene:	AGAP6 / 414189	HGNCID:	23466	Length:	686	Species:	Homo sapiens

Alignment Length:	737	Identity:	264/737 - (35%)
Similarity:	350/737 - (47%)	Gaps:	151/737 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 IRDEGGAPEMQF---AGWVDAVIFVFSLENEG-SFNTVYNYYTKMAHFRNGQEIPMILVGTQDAI 253
            :||......::|   |....:.||..:.:.|. .||...|........||.|         .|.:
Human    67 VRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQ---------TDVV 122

  Fly   254 SERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQD-ACQKILSQRLPLPPQVQPARPT 317
            ..|.....:...|.:.:..      |..|:|..|:.....|. ....|:|..|.:|..:     |
Human   123 EIRRSNCTNHVSAVRFSQQ------YSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHI-----T 176

  Fly   318 TPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAA 382
            ....:|....|          .:||     ..||.:...:...:....|..|.:::|    |...
Human   177 QRDADRTLSIP----------DEQL-----HSFAVSTVHIMKKRNGGGSLNNYSSSI----PSTP 222

  Fly   383 NSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSE- 446
            ::.|        .||: .:.||....|||     ..::|.|.||||  :|.|.:|.:||.|:.|
Human   223 STSQ--------EDPQ-FSVPPTANTPTP-----VCKRSMRWSNLF--TSEKGSDPDKERKAPEN 271

  Fly   447 ----LGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQY 507
                :||||:||||||.|.|||.|.| |.|||||||||.:|.|||:.||.|||.::|.|||.||.
Human   272 HADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQT 335

  Fly   508 VTVKVPGQKPRGSKSIITNSALT--SSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGA 570
            .|:||||:.|.     :..||.|  ||..:||               |:||
Human   336 STIKVPGKWPS-----LATSACTPISSSKSNG---------------LSKD-------------- 366

  Fly   571 GSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLE-AQTPNV-KKRHRRMK 633
              :..|.|               :.|..|.|.|.|        ...||. ..:|:. ||:|.:.|
Human   367 --MDTGLG---------------DSICFSPSISST--------TSPKLNPPPSPHANKKKHLKKK 406

  Fly   634 SSSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTK-QAT 697
            |::            .|.|||...:.|||||...||||.||.|::.:|..||||.||||:| |.|
Human   407 STN------------NFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLT 459

  Fly   698 STDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDW 762
            |...|..|...|.:.||..||||...||:||||||||||||||||:||:||.|:|:||||.||||
Human   460 SQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDW 524

  Fly   763 PSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPS 827
            |.....||.:|.|.||||:||.:::.:.||:.:::||:||||:|||||.|.||.||       |.
Human   525 PVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPL-------PC 582

  Fly   828 P--SPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNG 890
            .  |.||||:.|....|:::.:.:||:...|..|......|..|.|.|||..||:.:||||||.|
Human   583 TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647

  Fly   891 ANIKHTDHEGRTCLAYARAAQS 912
            .::...|..|.|.|.|||.|.|
Human   648 VDVMARDAHGNTALTYARQASS 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	21/111 (19%)
		RAS	144..295	CDD:214541	20/105 (19%)
		PH_AGAP	451..686	CDD:241281	87/238 (37%)
		PH	454..>521	CDD:278594	42/66 (64%)
		ArfGap	702..818	CDD:279720	68/115 (59%)
		ANK	<834..907	CDD:238125	26/72 (36%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	20/47 (43%)
		ANK repeat	868..897	CDD:293786	14/28 (50%)
AGAP6	NP_001071133.2	PH_AGAP	280..447	CDD:241281	87/238 (37%)
		PH	283..442	CDD:278594	83/230 (36%)
		ArfGap	466..580	CDD:279720	67/113 (59%)
		Ank_2	591..681	CDD:289560	31/79 (39%)
		ANK repeat	591..621	CDD:293786	7/29 (24%)
		ANK	<594..677	CDD:238125	30/76 (39%)
		ANK repeat	623..654	CDD:293786	15/30 (50%)
		ANK repeat	656..681	CDD:293786	8/14 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4206
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920