DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and arfgap3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_991160.1	Gene:	arfgap3 / 402889	ZFINID:	ZDB-GENE-040426-1	Length:	498	Species:	Danio rerio

Alignment Length:	294	Identity:	74/294 - (25%)
Similarity:	122/294 - (41%)	Gaps:	69/294 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   700 DLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLD-DWP 763
            :::|:|...:....|..|.||.|.||.|||:..||.:||:|||.||:||.|:|.:||..|| :|.
Zfish     8 EISAVLKRLRAAAANKVCFDCSAKNPSWASITYGVFLCIDCSGTHRSLGVHLSFIRSTELDSNWS 72

  Fly   764 SPHLSVMLAIGNSLANSVW-----ESNTRQRVKPTSQASR--EDKERWVRSKYEAKEFLTPLGNG 821
            ...|..|...||:.||:.:     .|::....|.:|:|:.  .||.|.:.:: ..::..|.|...
Zfish    73 WFQLRCMQVGGNASANAFFSQHGCSSSSAANAKYSSRAAALYRDKIRALANQ-ATRQHGTELWLD 136

  Fly   822 SSAHPSPS----PGQQLIEAVIRADIKSIVSI-LANCPSEVTNANVSARDVRTPLLLACAIGNLA 881
            :.|..|||    ..:.......::.:...|.: ::.....|.:.|.:|:....|     ::..|:
Zfish   137 AQAPLSPSSPLDKQEDFFTQHTQSALPDTVQLNISQSQKRVQDNNNNAKSEAGP-----SVEQLS 196

  Fly   882 IAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQ 946
            ::.:                     ..||:.|:..|...||....||           ||..|
Zfish   197 VSPV---------------------QSAAEPLSLLKKKPAAVRKSAG-----------GGRRA-- 227

  Fly   947 YNVEDTTALVELLEGLGCPEAAPLTASGTLPRRR 980
                          |||..:.:  :.|.||.:||
Zfish   228 --------------GLGAQKVS--SQSFTLQQRR 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	44/123 (36%)
		ANK	<834..907	CDD:238125	6/73 (8%)
		ANK repeat	834..866	CDD:293786	4/32 (13%)
		Ank_5	859..907	CDD:290568	4/47 (9%)
		ANK repeat	868..897	CDD:293786	2/28 (7%)
arfgap3	NP_991160.1	ArfGap	10..123	CDD:279720	43/112 (38%)
arfgap3	NP_991160.1	PLN03114	11..486	CDD:178661	74/291 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900