DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Agfg1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001129068.1	Gene:	Agfg1 / 363266	RGDID:	1560041	Length:	561	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	67/290 - (23%)
Similarity:	108/290 - (37%)	Gaps:	58/290 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 SSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLG-SHISK 753
            |:|.||....  ..||.....:|.|..|.||....|.:.::.:|..:|..|||..|.|. .|  :
  Rat     4 SAKRKQEEKH--LKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPH--R 64

  Fly   754 VRSLGLDDWPSPHLSVMLAIGNSLANSVWES--NTRQRVKPTSQASREDKERWVRSKYEAKEFLT 816
            |:|:.:..:....:..:...||.:...:|..  :.|....|..:..::.|| :::.|||.|.:..
  Rat    65 VKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSSAIPDFRDPQKVKE-FLQEKYEKKRWYV 128

  Fly   817 PLGNG---SSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEV-------TNANVSAR------ 865
            |....   :|.|.|.| |..........::|.:.|:|......:       |.:.|..|
  Rat   129 PPEQAKVVASVHASIS-GSSASSTSSTPEVKPLKSLLGESAPALHLNKGTPTQSPVVGRSQGQQQ 192

  Fly   866 ---------DVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKA 921
                     |:.:.:..|.|..:.|.|     |.||..|.:         :.|||:.|.|:....
  Rat   193 EKKQFDLLSDLGSDIFAAPAPQSTATA-----NFANFAHFN---------SHAAQNSANAEFANF 243

  Fly   922 AAAAQAG---------TTIPAP-APPTNGG 941
            .|..|:.         |...:| .|.|.||
  Rat   244 DAFGQSSGSSNFGGFPTASHSPFQPQTTGG 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	29/118 (25%)
		ANK	<834..907	CDD:238125	15/94 (16%)
		ANK repeat	834..866	CDD:293786	6/53 (11%)
		Ank_5	859..907	CDD:290568	11/62 (18%)
		ANK repeat	868..897	CDD:293786	8/28 (29%)
Agfg1	NP_001129068.1	COG5347	8..309	CDD:227651	65/286 (23%)
		ArfGap	14..135	CDD:214518	30/123 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..193		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..451
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810